Format

Send to:

Choose Destination

Links from PubChem BioAssay

See comment in PubMed Commons below
Bioorg Med Chem Lett. 2013 Jul 1;23(13):3818-21. doi: 10.1016/j.bmcl.2013.04.083. Epub 2013 May 6.

Inhibition of soluble epoxide hydrolase by fulvestrant and sulfoxides.

Author information

  • 1Department of Entomology and UCD Comprehensive Cancer Center, University of California, One Shields Avenue, Davis, CA 95616, USA. chmorisseau@ucdavis.edu

Abstract

The soluble epoxide hydrolase (sEH) is a key enzyme in the metabolism of epoxy-fatty acids, signaling molecules involved in numerous biologies. Toward finding novel inhibitors of sEH, a library of known drugs was tested for inhibition of sEH. We found that fulvestrant, an anticancer agent, is a potent (KI=26 nM) competitive inhibitor of sEH. From this observation, we found that alkyl-sulfoxides represent a new kind of pharmacophore for the inhibition of sEH.

Copyright © 2013 Elsevier Ltd. All rights reserved.

PMID:
23684894
[PubMed - indexed for MEDLINE]
PMCID:
PMC3703951
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk