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Links from PubChem BioAssay

Items: 19

1.

Phospholipase C epsilon scaffolds to muscle-specific A kinase anchoring protein (mAKAPbeta) and integrates multiple hypertrophic stimuli in cardiac myocytes.

Zhang L, Malik S, Kelley GG, Kapiloff MS, Smrcka AV.

J Biol Chem. 2011 Jul 1;286(26):23012-21. doi: 10.1074/jbc.M111.231993. Epub 2011 May 5.

2.

Direct activation of human phospholipase C by its well known inhibitor u73122.

Klein RR, Bourdon DM, Costales CL, Wagner CD, White WL, Williams JD, Hicks SN, Sondek J, Thakker DR.

J Biol Chem. 2011 Apr 8;286(14):12407-16. doi: 10.1074/jbc.M110.191783. Epub 2011 Jan 25.

3.

Phospholipase C beta 1 deficiency is associated with early-onset epileptic encephalopathy.

Kurian MA, Meyer E, Vassallo G, Morgan NV, Prakash N, Pasha S, Hai NA, Shuib S, Rahman F, Wassmer E, Cross JH, O'Callaghan FJ, Osborne JP, Scheffer IE, Gissen P, Maher ER.

Brain. 2010 Oct;133(10):2964-70. doi: 10.1093/brain/awq238. Epub 2010 Sep 9.

4.

The PI-PLC inhibitor U-73122 is a potent inhibitor of the SERCA pump in smooth muscle.

Hollywood MA, Sergeant GP, Thornbury KD, McHale NG.

Br J Pharmacol. 2010 Jul;160(6):1293-4. doi: 10.1111/j.1476-5381.2010.00795.x.

5.

Potential treatment of cardiac hypertrophy and heart failure by inhibiting the sarcolemmal binding of phospholipase Cbeta1b.

Woodcock EA, Grubb DR, Iliades P.

Curr Drug Targets. 2010 Aug;11(8):1032-40. Review.

PMID:
20426766
6.

U73122, an aminosteroid phospholipase C inhibitor, is a potent inhibitor of cardiac phospholipase D by a PIP2-dependent mechanism.

Burgdorf C, Schäfer U, Richardt G, Kurz T.

J Cardiovasc Pharmacol. 2010 Jun;55(6):555-9. doi: 10.1097/FJC.0b013e3181d8bec5.

PMID:
20179606
7.

Phospholipase Cgamma1 is required for metastasis development and progression.

Sala G, Dituri F, Raimondi C, Previdi S, Maffucci T, Mazzoletti M, Rossi C, Iezzi M, Lattanzio R, Piantelli M, Iacobelli S, Broggini M, Falasca M.

Cancer Res. 2008 Dec 15;68(24):10187-96. doi: 10.1158/0008-5472.CAN-08-1181.

8.

PLC-beta1 knockout mice as a model of disrupted cortical development and plasticity: behavioral endophenotypes and dysregulation of RGS4 gene expression.

McOmish CE, Burrows EL, Howard M, Hannan AJ.

Hippocampus. 2008;18(8):824-34. doi: 10.1002/hipo.20443.

PMID:
18493969
9.

Phospholipase C-beta 2 promotes mitosis and migration of human breast cancer-derived cells.

Bertagnolo V, Benedusi M, Brugnoli F, Lanuti P, Marchisio M, Querzoli P, Capitani S.

Carcinogenesis. 2007 Aug;28(8):1638-45. Epub 2007 Apr 11.

10.

The phosphoinositide-specific phospholipase C inhibitor U73122 (1-(6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione) spontaneously forms conjugates with common components of cell culture medium.

Wilsher NE, Court WJ, Ruddle R, Newbatt YM, Aherne W, Sheldrake PW, Jones NP, Katan M, Eccles SA, Raynaud FI.

Drug Metab Dispos. 2007 Jul;35(7):1017-22. Epub 2007 Apr 2.

11.

PLC gamma contributes to metastasis of in situ-occurring mammary and prostate tumors.

Shepard CR, Kassis J, Whaley DL, Kim HG, Wells A.

Oncogene. 2007 May 10;26(21):3020-6. Epub 2006 Nov 20.

PMID:
17130835
12.

Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible.

Hinkes B, Wiggins RC, Gbadegesin R, Vlangos CN, Seelow D, Nürnberg G, Garg P, Verma R, Chaib H, Hoskins BE, Ashraf S, Becker C, Hennies HC, Goyal M, Wharram BL, Schachter AD, Mudumana S, Drummond I, Kerjaschki D, Waldherr R, Dietrich A, Ozaltin F, Bakkaloglu A, Cleper R, Basel-Vanagaite L, Pohl M, Griebel M, Tsygin AN, Soylu A, Müller D, Sorli CS, Bunney TD, Katan M, Liu J, Attanasio M, O'toole JF, Hasselbacher K, Mucha B, Otto EA, Airik R, Kispert A, Kelley GG, Smrcka AV, Gudermann T, Holzman LB, Nürnberg P, Hildebrandt F.

Nat Genet. 2006 Dec;38(12):1397-405. Epub 2006 Nov 5.

PMID:
17086182
13.

Regulation of phospholipase C isozymes by ras superfamily GTPases.

Harden TK, Sondek J.

Annu Rev Pharmacol Toxicol. 2006;46:355-79. Review.

PMID:
16402909
17.
18.

Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils.

Bleasdale JE, Thakur NR, Gremban RS, Bundy GL, Fitzpatrick FA, Smith RJ, Bunting S.

J Pharmacol Exp Ther. 1990 Nov;255(2):756-68.

PMID:
2147038
19.

Characterization of the major phosphoinositide-specific phospholipase C of human amnion.

Bala GA, Thakur NR, Bleasdale JE.

Biol Reprod. 1990 Oct;43(4):704-11.

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