Abstract
Small molecules can control cell fate in vivo and may allow directed induction of desired cell types, providing an attractive alternative to transplant-based approaches in regenerative medicine. We have chemically induced functional oocytes in Caenorhabditis elegans adults that otherwise produced only sperm. These findings suggest that chemical approaches to therapeutic cell reprogramming may be feasible and provide a powerful platform for analyzing molecular mechanisms of in vivo cell reprogramming.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Butadienes / chemistry
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Butadienes / pharmacology*
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Caenorhabditis elegans / cytology*
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Caenorhabditis elegans / drug effects*
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Caenorhabditis elegans / embryology
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Cell Differentiation / drug effects
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Cell Lineage / drug effects
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Cellular Reprogramming*
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Female
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MAP Kinase Signaling System / drug effects
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Male
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Molecular Structure
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Nitriles / chemistry
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Nitriles / pharmacology*
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Oocytes / cytology
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Oocytes / drug effects
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Spermatozoa / cytology
Substances
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Butadienes
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Nitriles
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U 0126