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Bioorg Med Chem Lett. 2009 Mar 1;19(5):1517-21. doi: 10.1016/j.bmcl.2009.01.001. Epub 2009 Jan 9.

Synthesis and biological activity of anticoccidial agents: 2,3-diarylindoles.

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  • 1SCYNEXIS, Inc., Discovery Chemistry, PO Box 12878, Research Triangle Park, NC 27709-2878, USA.


Novel 2,3-diarylindoles bearing an amine substituent at the indole 5- and 6-positions have been synthesized and evaluated as anticoccidial agents in both in vitro and in vivo assays. Both subnanomolar in vitro activity and broad spectrum in vivo potency were detected for several compounds, particularly compound 27.

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