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Bioorg Med Chem Lett. 2006 Oct 1;16(19):5001-4. Epub 2006 Aug 1.

Identification of potent agonists of photoreceptor-specific nuclear receptor (NR2E3) and preparation of a radioligand.

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  • 1Department of Medicinal Chemistry, Technology Enabled Synthesis Group, Merck & Co., Inc., PO Box 4, West Point, PA 19486, USA. scott_wolkenberg@merck.com

Abstract

Agonists of NR2E3 (PNR, RNR) have been identified and optimized to EC(50)< 200 nM. A tritiated analogue of one agonist was prepared to aid in the development of a binding assay.

PMID:
16879962
[PubMed - indexed for MEDLINE]
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