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Bioorg Med Chem Lett. 2004 Oct 4;14(19):4949-53.

Synthesis and GABA receptor potency of 3-thiomethyl-4-(hetero)aryl-5-amino-1-phenylpyrazoles.

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  • 13-Dimensional Pharmaceuticals, Inc., A wholly owned Johnson & Johnson company, 665 Stockton Drive, Exton, PA 1934, USA.


A convenient synthetic route to novel 4-arylpyrazoles is described. The potential for insecticidal activity through GABA channel blockage by this series of compounds, as well as their selectivity for insect versus mammalian receptors, are explored through in vitro and in vivo assays.

[PubMed - indexed for MEDLINE]
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