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Bioorg Med Chem Lett. 2004 Oct 4;14(19):4949-53.

Synthesis and GABA receptor potency of 3-thiomethyl-4-(hetero)aryl-5-amino-1-phenylpyrazoles.

Author information

  • 13-Dimensional Pharmaceuticals, Inc., A wholly owned Johnson & Johnson company, 665 Stockton Drive, Exton, PA 1934, USA. smeegalla@prdus.jnj.com

Abstract

A convenient synthetic route to novel 4-arylpyrazoles is described. The potential for insecticidal activity through GABA channel blockage by this series of compounds, as well as their selectivity for insect versus mammalian receptors, are explored through in vitro and in vivo assays.

PMID:
15341958
[PubMed - indexed for MEDLINE]
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