Format

Send to:

Choose Destination

PubMed Citations for PubChem BioAssay (Select 102799)

See comment in PubMed Commons below
Bioorg Med Chem Lett. 1998 Mar 3;8(5):453-8.

A series of non-quinoline cysLT1 receptor antagonists: SAR study on pyridyl analogs of Singulair.

Author information

  • 1Merck Frosst Center for Therapeutic Research, Qu├ębec, Canada.

Abstract

The structure-activity relationship of a series of styrylpyridine analogs of MK-0476 (montelukast, Singulair) is described. This work has led to the identification of a number of potent and orally active cysLT1 receptor (LTD4 receptor) antagonists including 2ab (L-733,321) as an optimized candidate.

PMID:
9871597
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk