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Results: 1 to 20 of 176

1.

Activation of 3-phosphoinositide-dependent kinase 1 (PDK1) and serum- and glucocorticoid-induced protein kinase 1 (SGK1) by short-chain sphingolipid C4-ceramide rescues the trafficking defect of ΔF508-cystic fibrosis transmembrane conductance regulator (ΔF508-CFTR).

Caohuy H, Yang Q, Eudy Y, Ha TA, Xu AE, Glover M, Frizzell RA, Jozwik C, Pollard HB.

J Biol Chem. 2014 Dec 26;289(52):35953-68. doi: 10.1074/jbc.M114.598649. Epub 2014 Nov 10.

PMID:
25384981
[PubMed - in process]
2.

Phosphoinositide protein kinase PDPK1 is a crucial cell signaling mediator in multiple myeloma.

Chinen Y, Kuroda J, Shimura Y, Nagoshi H, Kiyota M, Yamamoto-Sugitani M, Mizutani S, Sakamoto N, Ri M, Kawata E, Kobayashi T, Matsumoto Y, Horiike S, Iida S, Taniwaki M.

Cancer Res. 2014 Dec 15;74(24):7418-29. doi: 10.1158/0008-5472.CAN-14-1420. Epub 2014 Sep 30.

PMID:
25269480
[PubMed - indexed for MEDLINE]
3.

Immunohistochemical analysis of PDK1 expression in breast cancer.

Arsenic R.

Diagn Pathol. 2014 Apr 16;9:82. doi: 10.1186/1746-1596-9-82.

PMID:
24739482
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease.

Butland SL, Sanders SS, Schmidt ME, Riechers SP, Lin DT, Martin DD, Vaid K, Graham RK, Singaraja RR, Wanker EE, Conibear E, Hayden MR.

Hum Mol Genet. 2014 Aug 1;23(15):4142-60. doi: 10.1093/hmg/ddu137. Epub 2014 Apr 4.

PMID:
24705354
[PubMed - indexed for MEDLINE]
5.

MicroRNA-375 targets PDK1 in pancreatic carcinoma and suppresses cell growth through the Akt signaling pathway.

Zhou J, Song S, He S, Zhu X, Zhang Y, Yi B, Zhang B, Qin G, Li D.

Int J Mol Med. 2014 Apr;33(4):950-6. doi: 10.3892/ijmm.2014.1638. Epub 2014 Jan 28.

PMID:
24481267
[PubMed - indexed for MEDLINE]
6.

The protein interaction landscape of the human CMGC kinase group.

Varjosalo M, Keskitalo S, Van Drogen A, Nurkkala H, Vichalkovski A, Aebersold R, Gstaiger M.

Cell Rep. 2013 Apr 25;3(4):1306-20. doi: 10.1016/j.celrep.2013.03.027. Epub 2013 Apr 18.

PMID:
23602568
[PubMed - indexed for MEDLINE]
Free Article
7.

Upregulation of PKCη by PKCε and PDK1 involves two distinct mechanisms and promotes breast cancer cell survival.

Pal D, Outram SP, Basu A.

Biochim Biophys Acta. 2013 Aug;1830(8):4040-5. doi: 10.1016/j.bbagen.2013.03.028. Epub 2013 Apr 4.

PMID:
23562764
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Transition from heterotypic to homotypic PDK1 homodimerization is essential for TCR-mediated NF-κB activation.

Kang JA, Jeong SP, Park D, Hayden MS, Ghosh S, Park SG.

J Immunol. 2013 May 1;190(9):4508-15. doi: 10.4049/jimmunol.1202923. Epub 2013 Mar 25.

PMID:
23530144
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer.

Eser S, Reiff N, Messer M, Seidler B, Gottschalk K, Dobler M, Hieber M, Arbeiter A, Klein S, Kong B, Michalski CW, Schlitter AM, Esposito I, Kind AJ, Rad L, Schnieke AE, Baccarini M, Alessi DR, Rad R, Schmid RM, Schneider G, Saur D.

Cancer Cell. 2013 Mar 18;23(3):406-20. doi: 10.1016/j.ccr.2013.01.023. Epub 2013 Feb 28.

PMID:
23453624
[PubMed - indexed for MEDLINE]
Free Article
10.

Proliferative and antiapoptotic signaling stimulated by nuclear-localized PDK1 results in oncogenesis.

Kikani CK, Verona EV, Ryu J, Shen Y, Ye Q, Zheng L, Qian Z, Sakaue H, Nakamura K, Du J, Ji Q, Ogawa W, Sun LZ, Dong LQ, Liu F.

Sci Signal. 2012 Nov 6;5(249):ra80. doi: 10.1126/scisignal.2003065.

PMID:
23131847
[PubMed - indexed for MEDLINE]
11.

Silencing of PDK1 gene expression by RNA interference suppresses growth of esophageal cancer.

Yu J, Chen KS, Li YN, Yang J, Zhao L.

Asian Pac J Cancer Prev. 2012;13(8):4147-51.

PMID:
23098536
[PubMed - indexed for MEDLINE]
Free Article
12.

3-phosphoinositide-dependent kinase 1 controls breast tumor growth in a kinase-dependent but Akt-independent manner.

Gagliardi PA, di Blasio L, Orso F, Seano G, Sessa R, Taverna D, Bussolino F, Primo L.

Neoplasia. 2012 Aug;14(8):719-31.

PMID:
22952425
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Effect of advanced glycation end products on lectin-like oxidized low density lipoprotein receptor-1 expression in endothelial cells.

Shiu SW, Wong Y, Tan KC.

J Atheroscler Thromb. 2012;19(12):1083-92. Epub 2012 Aug 1.

PMID:
22863784
[PubMed - indexed for MEDLINE]
Free Article
14.

Multiplexed protein signal pathway mapping identifies patients with rectal cancer that responds to neoadjuvant treatment.

Mammano E, Galdi F, Pierobon M, Tessari E, Deng J, Pucciarelli S, Agostini M, De Marchi F, Canzonieri V, De Paoli A, Belluco C, Liotta L, Petricoin E, Pilati P, Nitti D.

Clin Colorectal Cancer. 2012 Dec;11(4):268-74. doi: 10.1016/j.clcc.2012.05.003. Epub 2012 Jun 2.

PMID:
22658458
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

An ATP-site on-off switch that restricts phosphatase accessibility of Akt.

Lin K, Lin J, Wu WI, Ballard J, Lee BB, Gloor SL, Vigers GP, Morales TH, Friedman LS, Skelton N, Brandhuber BJ.

Sci Signal. 2012 May 8;5(223):ra37. doi: 10.1126/scisignal.2002618.

PMID:
22569334
[PubMed - indexed for MEDLINE]
Free Article
16.

Destabilization of PDK1 by Hsp90 inactivation suppresses hepatitis C virus replication through inhibition of PRK2-mediated viral RNA polymerase phosphorylation.

Kim MG, Moon JS, Kim EJ, Lee SH, Oh JW.

Biochem Biophys Res Commun. 2012 Apr 27;421(1):112-8. doi: 10.1016/j.bbrc.2012.03.126. Epub 2012 Apr 3.

PMID:
22490666
[PubMed - indexed for MEDLINE]
17.

A novel regulatory mechanism links PLCγ1 to PDK1.

Raimondi C, Chikh A, Wheeler AP, Maffucci T, Falasca M.

J Cell Sci. 2012 Jul 1;125(Pt 13):3153-63. doi: 10.1242/jcs.100511. Epub 2012 Mar 27.

PMID:
22454520
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

PDK1 in apical signaling endosomes participates in the rescue of the polarity complex atypical PKC by intermediate filaments in intestinal epithelia.

Mashukova A, Forteza R, Wald FA, Salas PJ.

Mol Biol Cell. 2012 May;23(9):1664-74. doi: 10.1091/mbc.E11-12-0988. Epub 2012 Mar 7.

PMID:
22398726
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Ubiquitin-specific protease 4 inhibits mono-ubiquitination of the master growth factor signaling kinase PDK1.

Uras IZ, List T, Nijman SM.

PLoS One. 2012;7(2):e31003. doi: 10.1371/journal.pone.0031003. Epub 2012 Feb 7.

PMID:
22347420
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Structure-based design of PDK1 inhibitors.

Poulsen A, Blanchard S, Soh CK, Lee C, Williams M, Wang H, Dymock B.

Bioorg Med Chem Lett. 2012 Jan 1;22(1):305-7. doi: 10.1016/j.bmcl.2011.11.006. Epub 2011 Nov 9.

PMID:
22119465
[PubMed - indexed for MEDLINE]
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