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Items: 1 to 20 of 87

1.

Impaired degradation of WNK by Akt and PKA phosphorylation of KLHL3.

Yoshizaki Y, Mori Y, Tsuzaki Y, Mori T, Nomura N, Wakabayashi M, Takahashi D, Zeniya M, Kikuchi E, Araki Y, Ando F, Isobe K, Nishida H, Ohta A, Susa K, Inoue Y, Chiga M, Rai T, Sasaki S, Uchida S, Sohara E.

Biochem Biophys Res Commun. 2015 Nov 13;467(2):229-34. doi: 10.1016/j.bbrc.2015.09.184. Epub 2015 Oct 3.

PMID:
26435498
2.

Src-family protein tyrosine kinase phosphorylates WNK4 and modulates its inhibitory effect on KCNJ1 (ROMK).

Lin DH, Yue P, Yarborough O 3rd, Scholl UI, Giebisch G, Lifton RP, Rinehart J, Wang WH.

Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4495-500. doi: 10.1073/pnas.1503437112. Epub 2015 Mar 24.

3.

Angiotensin II signaling via protein kinase C phosphorylates Kelch-like 3, preventing WNK4 degradation.

Shibata S, Arroyo JP, Castañeda-Bueno M, Puthumana J, Zhang J, Uchida S, Stone KL, Lam TT, Lifton RP.

Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15556-61. doi: 10.1073/pnas.1418342111. Epub 2014 Oct 13.

4.

Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation.

Schumacher FR, Sorrell FJ, Alessi DR, Bullock AN, Kurz T.

Biochem J. 2014 Jun 1;460(2):237-46. doi: 10.1042/BJ20140153.

5.

Insights in cullin 3/WNK4 and its relationship to blood pressure regulation and electrolyte homeostasis.

Andérica-Romero AC, Escobar L, Padilla-Flores T, Pedraza-Chaverri J.

Cell Signal. 2014 Jun;26(6):1166-72. doi: 10.1016/j.cellsig.2014.01.032. Epub 2014 Feb 8. Review.

PMID:
24518042
6.

WNK4 inhibits plasma membrane targeting of NCC through regulation of syntaxin13 SNARE formation.

Chung WY, Park HW, Han JW, Lee MG, Kim JY.

Cell Signal. 2013 Dec;25(12):2469-77. doi: 10.1016/j.cellsig.2013.08.006. Epub 2013 Aug 30.

PMID:
23993962
7.

Decrease of WNK4 ubiquitination by disease-causing mutations of KLHL3 through different molecular mechanisms.

Mori Y, Wakabayashi M, Mori T, Araki Y, Sohara E, Rai T, Sasaki S, Uchida S.

Biochem Biophys Res Commun. 2013 Sep 13;439(1):30-4. doi: 10.1016/j.bbrc.2013.08.035. Epub 2013 Aug 17.

PMID:
23962426
8.

Regulation of large-conductance Ca2+-activated K+ channels by WNK4 kinase.

Wang Z, Subramanya AR, Satlin LM, Pastor-Soler NM, Carattino MD, Kleyman TR.

Am J Physiol Cell Physiol. 2013 Oct 15;305(8):C846-53. doi: 10.1152/ajpcell.00133.2013. Epub 2013 Jul 24.

9.

KLHL2 interacts with and ubiquitinates WNK kinases.

Takahashi D, Mori T, Wakabayashi M, Mori Y, Susa K, Zeniya M, Sohara E, Rai T, Sasaki S, Uchida S.

Biochem Biophys Res Commun. 2013 Aug 2;437(3):457-62. doi: 10.1016/j.bbrc.2013.06.104. Epub 2013 Jul 6.

PMID:
23838290
10.

Disease-causing mutations in KLHL3 impair its effect on WNK4 degradation.

Wu G, Peng JB.

FEBS Lett. 2013 Jun 19;587(12):1717-22. doi: 10.1016/j.febslet.2013.04.032. Epub 2013 May 9.

11.

WNK4 inhibition of ENaC is independent of Nedd4-2-mediated ENaC ubiquitination.

Yu L, Cai H, Yue Q, Alli AA, Wang D, Al-Khalili O, Bao HF, Eaton DC.

Am J Physiol Renal Physiol. 2013 Jul 1;305(1):F31-41. doi: 10.1152/ajprenal.00652.2012. Epub 2013 Apr 17.

12.

Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4.

Shibata S, Zhang J, Puthumana J, Stone KL, Lifton RP.

Proc Natl Acad Sci U S A. 2013 May 7;110(19):7838-43. doi: 10.1073/pnas.1304592110. Epub 2013 Apr 1.

13.

Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension.

Wakabayashi M, Mori T, Isobe K, Sohara E, Susa K, Araki Y, Chiga M, Kikuchi E, Nomura N, Mori Y, Matsuo H, Murata T, Nomura S, Asano T, Kawaguchi H, Nonoyama S, Rai T, Sasaki S, Uchida S.

Cell Rep. 2013 Mar 28;3(3):858-68. doi: 10.1016/j.celrep.2013.02.024. Epub 2013 Feb 28.

14.

The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction.

Ohta A, Schumacher FR, Mehellou Y, Johnson C, Knebel A, Macartney TJ, Wood NT, Alessi DR, Kurz T.

Biochem J. 2013 Apr 1;451(1):111-22. doi: 10.1042/BJ20121903.

15.

Disease-causing R1185C mutation of WNK4 disrupts a regulatory mechanism involving calmodulin binding and SGK1 phosphorylation sites.

Na T, Wu G, Zhang W, Dong WJ, Peng JB.

Am J Physiol Renal Physiol. 2013 Jan 1;304(1):F8-F18. doi: 10.1152/ajprenal.00284.2012. Epub 2012 Oct 10.

16.

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.

Taipale M, Krykbaeva I, Koeva M, Kayatekin C, Westover KD, Karras GI, Lindquist S.

Cell. 2012 Aug 31;150(5):987-1001. doi: 10.1016/j.cell.2012.06.047.

17.

Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities.

Boyden LM, Choi M, Choate KA, Nelson-Williams CJ, Farhi A, Toka HR, Tikhonova IR, Bjornson R, Mane SM, Colussi G, Lebel M, Gordon RD, Semmekrot BA, Poujol A, Välimäki MJ, De Ferrari ME, Sanjad SA, Gutkin M, Karet FE, Tucci JR, Stockigt JR, Keppler-Noreuil KM, Porter CC, Anand SK, Whiteford ML, Davis ID, Dewar SB, Bettinelli A, Fadrowski JJ, Belsha CW, Hunley TE, Nelson RD, Trachtman H, Cole TR, Pinsk M, Bockenhauer D, Shenoy M, Vaidyanathan P, Foreman JW, Rasoulpour M, Thameem F, Al-Shahrouri HZ, Radhakrishnan J, Gharavi AG, Goilav B, Lifton RP.

Nature. 2012 Jan 22;482(7383):98-102. doi: 10.1038/nature10814.

18.

Pseudohypoaldosteronism Type II.

Wilson FH, Kahle KT.

In: Pagon RA, Adam MP, Ardinger HH, Wallace SE, Amemiya A, Bean LJH, Bird TD, Fong CT, Mefford HC, Smith RJH, Stephens K, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2016.
2011 Nov 10 [updated 2014 Jan 16].

19.

Antagonistic regulation of cystic fibrosis transmembrane conductance regulator cell surface expression by protein kinases WNK4 and spleen tyrosine kinase.

Mendes AI, Matos P, Moniz S, Luz S, Amaral MD, Farinha CM, Jordan P.

Mol Cell Biol. 2011 Oct;31(19):4076-86. doi: 10.1128/MCB.05152-11. Epub 2011 Aug 1.

20.

Hypertension associated polymorphisms in WNK1/WNK4 are not associated with hydrochlorothiazide response.

Han Y, Fan X, Sun K, Wang X, Wang Y, Chen J, Zhen Y, Zhang W, Hui R.

Clin Biochem. 2011 Sep;44(13):1045-9. doi: 10.1016/j.clinbiochem.2011.06.008. Epub 2011 Jun 17.

PMID:
21704025
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