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Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20482-7. doi: 10.1073/pnas.0807979105. Epub 2008 Nov 25.

A highly prevalent and genetically diversified Picornaviridae genus in South Asian children.

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  • 1Blood Systems Research Institute, San Francisco CA 94118, USA.

Abstract

Viral metagenomics focused on particle-protected nucleic acids was used on the stools of South Asian children with nonpolio acute flaccid paralysis (AFP). We identified sequences distantly related to Seneca Valley virus and cardioviruses that were then used as genetic footholds to characterize multiple viral species within a previously unreported genus of the Picornaviridae family. The picornaviruses were detected in the stools of >40% of AFP and healthy Pakistani children. A genetically diverse and highly prevalent enteric viral infection, characteristics similar to the Enterovirus genus, was therefore identified substantially expanding the genetic diversity of the RNA viral flora commonly found in children.

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PMID:
19033469
[PubMed - indexed for MEDLINE]
PMCID:
PMC2629322
Free PMC Article

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