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Proc Natl Acad Sci U S A. 2004 May 11;101(19):7329-34. Epub 2004 May 3.

The diploid genome sequence of Candida albicans.

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  • 1Stanford Genome Technology Center, Palo Alto, CA 94304, USA.

Abstract

We present the diploid genome sequence of the fungal pathogen Candida albicans. Because C. albicans has no known haploid or homozygous form, sequencing was performed as a whole-genome shotgun of the heterozygous diploid genome in strain SC5314, a clinical isolate that is the parent of strains widely used for molecular analysis. We developed computational methods to assemble a diploid genome sequence in good agreement with available physical mapping data. We provide a whole-genome description of heterozygosity in the organism. Comparative genomic analyses provide important clues about the evolution of the species and its mechanisms of pathogenesis.

PMID:
15123810
[PubMed - indexed for MEDLINE]
PMCID:
PMC409918
Free PMC Article

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