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Appl Environ Microbiol. 2002 May;68(5):2589-94.

Genomic sequence and evolution of marine cyanophage P60: a new insight on lytic and lysogenic phages.

Author information

  • 1Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, Maryland 21202, USA. chenf@umbi.umd.edu

Abstract

The genome of cyanophage P60, a lytic virus which infects marine Synechococcus WH7803, was completely sequenced. The P60 genome contained 47,872 bp with 80 potential open reading frames that were mostly similar to the genes found in lytic phages like T7, phi-YeO3-12, and SIO1. The DNA replication system, consisting of primase-helicase and DNA polymerase, appeared to be more conserved in podoviruses than in siphoviruses and myoviruses, suggesting that DNA replication genes could be the critical elements for lytic phages. Strikingly high sequence similarities in the regions coding for nucleotide metabolism were found between cyanophage P60 and marine unicellular cyanobacteria.

PMID:
11976141
[PubMed - indexed for MEDLINE]
PMCID:
PMC127578
Free PMC Article
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