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Results: 1 to 20 of 61

1.

LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity.

Parisiadou L, Yu J, Sgobio C, Xie C, Liu G, Sun L, Gu XL, Lin X, Crowley NA, Lovinger DM, Cai H.

Nat Neurosci. 2014 Mar;17(3):367-76. doi: 10.1038/nn.3636. Epub 2014 Jan 26.

PMID:
24464040
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation.

Law BM, Spain VA, Leinster VH, Chia R, Beilina A, Cho HJ, Taymans JM, Urban MK, Sancho RM, Ramírez MB, Biskup S, Baekelandt V, Cai H, Cookson MR, Berwick DC, Harvey K.

J Biol Chem. 2014 Jan 10;289(2):895-908. doi: 10.1074/jbc.M113.507913. Epub 2013 Nov 25.

PMID:
24275654
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

LRRK2 affects vesicle trafficking, neurotransmitter extracellular level and membrane receptor localization.

Migheli R, Del Giudice MG, Spissu Y, Sanna G, Xiong Y, Dawson TM, Dawson VL, Galioto M, Rocchitta G, Biosa A, Serra PA, Carri MT, Crosio C, Iaccarino C.

PLoS One. 2013 Oct 22;8(10):e77198. doi: 10.1371/journal.pone.0077198. eCollection 2013.

PMID:
24167564
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

LRRK2 phosphorylates novel tau epitopes and promotes tauopathy.

Bailey RM, Covy JP, Melrose HL, Rousseau L, Watkinson R, Knight J, Miles S, Farrer MJ, Dickson DW, Giasson BI, Lewis J.

Acta Neuropathol. 2013 Dec;126(6):809-27. doi: 10.1007/s00401-013-1188-4. Epub 2013 Oct 11.

PMID:
24113872
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25.

Yun HJ, Park J, Ho DH, Kim H, Kim CH, Oh H, Ga I, Seo H, Chang S, Son I, Seol W.

Exp Mol Med. 2013 Aug 16;45:e36. doi: 10.1038/emm.2013.68.

PMID:
23949442
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Non-motor and motor features in LRRK2 transgenic mice.

Bichler Z, Lim HC, Zeng L, Tan EK.

PLoS One. 2013 Jul 30;8(7):e70249. doi: 10.1371/journal.pone.0070249. Print 2013.

PMID:
23936174
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

LRRK2 secretion in exosomes is regulated by 14-3-3.

Fraser KB, Moehle MS, Daher JP, Webber PJ, Williams JY, Stewart CA, Yacoubian TA, Cowell RM, Dokland T, Ye T, Chen D, Siegal GP, Galemmo RA, Tsika E, Moore DJ, Standaert DG, Kojima K, Mobley JA, West AB.

Hum Mol Genet. 2013 Dec 15;22(24):4988-5000. doi: 10.1093/hmg/ddt346. Epub 2013 Jul 25.

PMID:
23886663
[PubMed - indexed for MEDLINE]
8.

Short- and long-term effects of LRRK2 on axon and dendrite growth.

Sepulveda B, Mesias R, Li X, Yue Z, Benson DL.

PLoS One. 2013 Apr 30;8(4):e61986. doi: 10.1371/journal.pone.0061986. Print 2013.

PMID:
23646112
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

The parkinson's disease-associated LRRK2 mutation R1441G inhibits neuronal differentiation of neural stem cells.

Bahnassawy L, Nicklas S, Palm T, Menzl I, Birzele F, Gillardon F, Schwamborn JC.

Stem Cells Dev. 2013 Sep 15;22(18):2487-96. doi: 10.1089/scd.2013.0163. Epub 2013 May 24.

PMID:
23600457
[PubMed - indexed for MEDLINE]
10.

Targeted disruption of leucine-rich repeat kinase 1 but not leucine-rich repeat kinase 2 in mice causes severe osteopetrosis.

Xing W, Liu J, Cheng S, Vogel P, Mohan S, Brommage R.

J Bone Miner Res. 2013 Sep;28(9):1962-74. doi: 10.1002/jbmr.1935.

PMID:
23526378
[PubMed - indexed for MEDLINE]
11.

Leucine-rich repeat kinase 2 functionally interacts with microtubules and kinase-dependently modulates cell migration.

Caesar M, Zach S, Carlson CB, Brockmann K, Gasser T, Gillardon F.

Neurobiol Dis. 2013 Jun;54:280-8. doi: 10.1016/j.nbd.2012.12.019. Epub 2013 Jan 11.

PMID:
23318930
[PubMed - indexed for MEDLINE]
12.

Enhanced dendritogenesis and axogenesis in hippocampal neuroblasts of LRRK2 knockout mice.

Paus M, Kohl Z, Ben Abdallah NM, Galter D, Gillardon F, Winkler J.

Brain Res. 2013 Feb 25;1497:85-100. doi: 10.1016/j.brainres.2012.12.024. Epub 2012 Dec 25.

PMID:
23270607
[PubMed - indexed for MEDLINE]
13.

Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations.

Sheng Z, Zhang S, Bustos D, Kleinheinz T, Le Pichon CE, Dominguez SL, Solanoy HO, Drummond J, Zhang X, Ding X, Cai F, Song Q, Li X, Yue Z, van der Brug MP, Burdick DJ, Gunzner-Toste J, Chen H, Liu X, Estrada AA, Sweeney ZK, Scearce-Levie K, Moffat JG, Kirkpatrick DS, Zhu H.

Sci Transl Med. 2012 Dec 12;4(164):164ra161. doi: 10.1126/scitranslmed.3004485.

PMID:
23241745
[PubMed - indexed for MEDLINE]
Free Article
14.

Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons.

Cherra SJ 3rd, Steer E, Gusdon AM, Kiselyov K, Chu CT.

Am J Pathol. 2013 Feb;182(2):474-84. doi: 10.1016/j.ajpath.2012.10.027. Epub 2012 Dec 8.

PMID:
23231918
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

LRRK2 interactions with α-synuclein in Parkinson's disease brains and in cell models.

Guerreiro PS, Huang Y, Gysbers A, Cheng D, Gai WP, Outeiro TF, Halliday GM.

J Mol Med (Berl). 2013 Apr;91(4):513-22. doi: 10.1007/s00109-012-0984-y. Epub 2012 Nov 27.

PMID:
23183827
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Phosphorylation of 4E-BP1 in the mammalian brain is not altered by LRRK2 expression or pathogenic mutations.

Trancikova A, Mamais A, Webber PJ, Stafa K, Tsika E, Glauser L, West AB, Bandopadhyay R, Moore DJ.

PLoS One. 2012;7(10):e47784. doi: 10.1371/journal.pone.0047784. Epub 2012 Oct 17.

PMID:
23082216
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Genetic analysis of Parkinson's disease-linked leucine-rich repeat kinase 2.

Tong Y, Shen J.

Biochem Soc Trans. 2012 Oct;40(5):1042-6. Review.

PMID:
22988862
[PubMed - indexed for MEDLINE]
18.

LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6.

Berwick DC, Harvey K.

Hum Mol Genet. 2012 Nov 15;21(22):4966-79. doi: 10.1093/hmg/dds342. Epub 2012 Aug 16.

PMID:
22899650
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

LRRK2 expression is enriched in the striosomal compartment of mouse striatum.

Mandemakers W, Snellinx A, O'Neill MJ, de Strooper B.

Neurobiol Dis. 2012 Dec;48(3):582-93. doi: 10.1016/j.nbd.2012.07.017. Epub 2012 Jul 29.

PMID:
22850484
[PubMed - indexed for MEDLINE]
20.

G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization.

Papkovskaia TD, Chau KY, Inesta-Vaquera F, Papkovsky DB, Healy DG, Nishio K, Staddon J, Duchen MR, Hardy J, Schapira AH, Cooper JM.

Hum Mol Genet. 2012 Oct 1;21(19):4201-13. doi: 10.1093/hmg/dds244. Epub 2012 Jun 26.

PMID:
22736029
[PubMed - indexed for MEDLINE]
Free PMC Article

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