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Results: 1 to 20 of 31

1.

Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials.

Gold B, Pingle M, Brickner SJ, Shah N, Roberts J, Rundell M, Bracken WC, Warrier T, Somersan S, Venugopal A, Darby C, Jiang X, Warren JD, Fernandez J, Ouerfelli O, Nuermberger EL, Cunningham-Bussel A, Rath P, Chidawanyika T, Deng H, Realubit R, Glickman JF, Nathan CF.

Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16004-11. doi: 10.1073/pnas.1214188109. Epub 2012 Sep 10.

PMID:
23012453
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Eradication of bacterial persisters with antibiotic-generated hydroxyl radicals.

Grant SS, Kaufmann BB, Chand NS, Haseley N, Hung DT.

Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12147-52. doi: 10.1073/pnas.1203735109. Epub 2012 Jul 9.

PMID:
22778419
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening.

Stanley SA, Grant SS, Kawate T, Iwase N, Shimizu M, Wivagg C, Silvis M, Kazyanskaya E, Aquadro J, Golas A, Fitzgerald M, Dai H, Zhang L, Hung DT.

ACS Chem Biol. 2012 Aug 17;7(8):1377-84. doi: 10.1021/cb300151m. Epub 2012 May 21.

PMID:
22577943
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

A high-throughput screen to identify inhibitors of ATP homeostasis in non-replicating Mycobacterium tuberculosis.

Mak PA, Rao SP, Ping Tan M, Lin X, Chyba J, Tay J, Ng SH, Tan BH, Cherian J, Duraiswamy J, Bifani P, Lim V, Lee BH, Ling Ma N, Beer D, Thayalan P, Kuhen K, Chatterjee A, Supek F, Glynne R, Zheng J, Boshoff HI, Barry CE 3rd, Dick T, Pethe K, Camacho LR.

ACS Chem Biol. 2012 Jul 20;7(7):1190-7. doi: 10.1021/cb2004884. Epub 2012 Apr 25.

PMID:
22500615
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Characterization and transcriptome analysis of Mycobacterium tuberculosis persisters.

Keren I, Minami S, Rubin E, Lewis K.

MBio. 2011 Jun 14;2(3):e00100-11. doi: 10.1128/mBio.00100-11. Print 2011.

PMID:
21673191
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

The three RelE homologs of Mycobacterium tuberculosis have individual, drug-specific effects on bacterial antibiotic tolerance.

Singh R, Barry CE 3rd, Boshoff HI.

J Bacteriol. 2010 Mar;192(5):1279-91. doi: 10.1128/JB.01285-09. Epub 2010 Jan 8.

PMID:
20061486
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Mechanisms of drug resistance in Mycobacterium tuberculosis.

Zhang Y, Yew WW.

Int J Tuberc Lung Dis. 2009 Nov;13(11):1320-30. Review.

PMID:
19861002
[PubMed - indexed for MEDLINE]
8.

Identifying the proteins to which small-molecule probes and drugs bind in cells.

Ong SE, Schenone M, Margolin AA, Li X, Do K, Doud MK, Mani DR, Kuai L, Wang X, Wood JL, Tolliday NJ, Koehler AN, Marcaurelle LA, Golub TR, Gould RJ, Schreiber SL, Carr SA.

Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4617-22. doi: 10.1073/pnas.0900191106. Epub 2009 Mar 2.

PMID:
19255428
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Diarylquinolines are bactericidal for dormant mycobacteria as a result of disturbed ATP homeostasis.

Koul A, Vranckx L, Dendouga N, Balemans W, Van den Wyngaert I, Vergauwen K, Göhlmann HW, Willebrords R, Poncelet A, Guillemont J, Bald D, Andries K.

J Biol Chem. 2008 Sep 12;283(37):25273-80. doi: 10.1074/jbc.M803899200. Epub 2008 Jul 14.

PMID:
18625705
[PubMed - indexed for MEDLINE]
Free Article
10.

Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates.

Via LE, Lin PL, Ray SM, Carrillo J, Allen SS, Eum SY, Taylor K, Klein E, Manjunatha U, Gonzales J, Lee EG, Park SK, Raleigh JA, Cho SN, McMurray DN, Flynn JL, Barry CE 3rd.

Infect Immun. 2008 Jun;76(6):2333-40. doi: 10.1128/IAI.01515-07. Epub 2008 Mar 17.

PMID:
18347040
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Selective killing of nonreplicating mycobacteria.

Bryk R, Gold B, Venugopal A, Singh J, Samy R, Pupek K, Cao H, Popescu C, Gurney M, Hotha S, Cherian J, Rhee K, Ly L, Converse PJ, Ehrt S, Vandal O, Jiang X, Schneider J, Lin G, Nathan C.

Cell Host Microbe. 2008 Mar 13;3(3):137-45. doi: 10.1016/j.chom.2008.02.003.

PMID:
18329613
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Drugs versus bugs: in pursuit of the persistent predator Mycobacterium tuberculosis.

Sacchettini JC, Rubin EJ, Freundlich JS.

Nat Rev Microbiol. 2008 Jan;6(1):41-52. Review.

PMID:
18079742
[PubMed - indexed for MEDLINE]
13.

Diarylquinolines target subunit c of mycobacterial ATP synthase.

Koul A, Dendouga N, Vergauwen K, Molenberghs B, Vranckx L, Willebrords R, Ristic Z, Lill H, Dorange I, Guillemont J, Bald D, Andries K.

Nat Chem Biol. 2007 Jun;3(6):323-4. Epub 2007 May 13.

PMID:
17496888
[PubMed - indexed for MEDLINE]
14.

Why is long-term therapy required to cure tuberculosis?

Connolly LE, Edelstein PH, Ramakrishnan L.

PLoS Med. 2007 Mar;4(3):e120. No abstract available.

PMID:
17388672
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Tuberculosis chemotherapy: the influence of bacillary stress and damage response pathways on drug efficacy.

Warner DF, Mizrahi V.

Clin Microbiol Rev. 2006 Jul;19(3):558-70. Review.

PMID:
16847086
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Non-inherited antibiotic resistance.

Levin BR, Rozen DE.

Nat Rev Microbiol. 2006 Jul;4(7):556-62. Review.

PMID:
16778840
[PubMed - indexed for MEDLINE]
17.

Differential antibiotic susceptibilities of starved Mycobacterium tuberculosis isolates.

Xie Z, Siddiqi N, Rubin EJ.

Antimicrob Agents Chemother. 2005 Nov;49(11):4778-80.

PMID:
16251329
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Controlling gene expression in mycobacteria with anhydrotetracycline and Tet repressor.

Ehrt S, Guo XV, Hickey CM, Ryou M, Monteleone M, Riley LW, Schnappinger D.

Nucleic Acids Res. 2005 Feb 1;33(2):e21.

PMID:
15687379
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

A genome-wide overexpression screen in yeast for small-molecule target identification.

Luesch H, Wu TY, Ren P, Gray NS, Schultz PG, Supek F.

Chem Biol. 2005 Jan;12(1):55-63.

PMID:
15664515
[PubMed - indexed for MEDLINE]
Free Article
20.

A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis.

Andries K, Verhasselt P, Guillemont J, Göhlmann HW, Neefs JM, Winkler H, Van Gestel J, Timmerman P, Zhu M, Lee E, Williams P, de Chaffoy D, Huitric E, Hoffner S, Cambau E, Truffot-Pernot C, Lounis N, Jarlier V.

Science. 2005 Jan 14;307(5707):223-7. Epub 2004 Dec 9.

PMID:
15591164
[PubMed - indexed for MEDLINE]
Free Article
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