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Items: 1 to 20 of 228

1.
2.

Structural basis for the lower affinity of the insulin-like growth factors for the insulin receptor.

Gauguin L, Klaproth B, Sajid W, Andersen AS, McNeil KA, Forbes BE, De Meyts P.

J Biol Chem. 2008 Feb 1;283(5):2604-13. Epub 2007 Nov 29.

3.

Rescue of ligand binding of a mutant IGF-I receptor by complementation.

Chakravarty A, Hinrichsen J, Whittaker L, Whittaker J.

Biochem Biophys Res Commun. 2005 May 27;331(1):74-7.

PMID:
15845360
4.

Characterization of the functional insulin binding epitopes of the full-length insulin receptor.

Whittaker J, Whittaker L.

J Biol Chem. 2005 Jun 3;280(22):20932-6. Epub 2005 Mar 30.

5.

Diabetes-associated mutations in human insulin: crystal structure and photo-cross-linking studies of a-chain variant insulin Wakayama.

Wan ZL, Huang K, Xu B, Hu SQ, Wang S, Chu YC, Katsoyannis PG, Weiss MA.

Biochemistry. 2005 Apr 5;44(13):5000-16.

PMID:
15794638
6.

Homozygous and heterozygous expression of a novel insulin-like growth factor-I mutation.

Walenkamp MJ, Karperien M, Pereira AM, Hilhorst-Hofstee Y, van Doorn J, Chen JW, Mohan S, Denley A, Forbes B, van Duyvenvoorde HA, van Thiel SW, Sluimers CA, Bax JJ, de Laat JA, Breuning MB, Romijn JA, Wit JM.

J Clin Endocrinol Metab. 2005 May;90(5):2855-64. Epub 2005 Mar 15.

PMID:
15769976
7.

Enhancing the activity of insulin at the receptor interface: crystal structure and photo-cross-linking of A8 analogues.

Wan Z, Xu B, Huang K, Chu YC, Li B, Nakagawa SH, Qu Y, Hu SQ, Katsoyannis PG, Weiss MA.

Biochemistry. 2004 Dec 28;43(51):16119-33.

PMID:
15610006
8.

Structural and functional characteristics of the Val44Met insulin-like growth factor I missense mutation: correlation with effects on growth and development.

Denley A, Wang CC, McNeil KA, Walenkamp MJ, van Duyvenvoorde H, Wit JM, Wallace JC, Norton RS, Karperien M, Forbes BE.

Mol Endocrinol. 2005 Mar;19(3):711-21. Epub 2004 Dec 2.

PMID:
15576456
9.

Insulin and its receptor: structure, function and evolution.

De Meyts P.

Bioessays. 2004 Dec;26(12):1351-62. Review.

PMID:
15551269
10.

How insulin binds: the B-chain alpha-helix contacts the L1 beta-helix of the insulin receptor.

Huang K, Xu B, Hu SQ, Chu YC, Hua QX, Qu Y, Li B, Wang S, Wang RY, Nakagawa SH, Theede AM, Whittaker J, De Meyts P, Katsoyannis PG, Weiss MA.

J Mol Biol. 2004 Aug 6;341(2):529-50.

PMID:
15276842
11.

Diabetes-associated mutations in insulin: consecutive residues in the B chain contact distinct domains of the insulin receptor.

Xu B, Hu SQ, Chu YC, Huang K, Nakagawa SH, Whittaker J, Katsoyannis PG, Weiss MA.

Biochemistry. 2004 Jul 6;43(26):8356-72.

PMID:
15222748
12.

Structural determinants for high-affinity binding of insulin-like growth factor II to insulin receptor (IR)-A, the exon 11 minus isoform of the IR.

Denley A, Bonython ER, Booker GW, Cosgrove LJ, Forbes BE, Ward CW, Wallace JC.

Mol Endocrinol. 2004 Oct;18(10):2502-12. Epub 2004 Jun 17.

PMID:
15205474
13.

Mapping of the insulin-like growth factor II binding site of the Type I insulin-like growth factor receptor by alanine scanning mutagenesis.

Sørensen H, Whittaker L, Hinrichsen J, Groth A, Whittaker J.

FEBS Lett. 2004 May 7;565(1-3):19-22.

14.

The insulin-like growth factors and insulin-signalling systems: an appealing target for breast cancer therapy?

Gray SG, Stenfeldt Mathiasen I, De Meyts P.

Horm Metab Res. 2003 Nov-Dec;35(11-12):857-71. Review. Erratum in: Horm Metab Res. 2004 Jan;36(1):74.

PMID:
14710369
15.
16.

A second insulin gene in fish genomes.

Irwin DM.

Gen Comp Endocrinol. 2004 Jan 1;135(1):150-8.

PMID:
14644655
17.

Testis determination requires insulin receptor family function in mice.

Nef S, Verma-Kurvari S, Merenmies J, Vassalli JD, Efstratiadis A, Accili D, Parada LF.

Nature. 2003 Nov 20;426(6964):291-5.

18.

The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics.

Stein LD, Bao Z, Blasiar D, Blumenthal T, Brent MR, Chen N, Chinwalla A, Clarke L, Clee C, Coghlan A, Coulson A, D'Eustachio P, Fitch DH, Fulton LA, Fulton RE, Griffiths-Jones S, Harris TW, Hillier LW, Kamath R, Kuwabara PE, Mardis ER, Marra MA, Miner TL, Minx P, Mullikin JC, Plumb RW, Rogers J, Schein JE, Sohrmann M, Spieth J, Stajich JE, Wei C, Willey D, Wilson RK, Durbin R, Waterston RH.

PLoS Biol. 2003 Nov;1(2):E45. Epub 2003 Nov 17.

19.

Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans.

Barbieri M, Bonafè M, Franceschi C, Paolisso G.

Am J Physiol Endocrinol Metab. 2003 Nov;285(5):E1064-71. Review.

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