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J Bacteriol. 2011 Feb;193(4):1018-20. doi: 10.1128/JB.01158-10. Epub 2010 Oct 8.

Whole-genome sequences of thirteen isolates of Borrelia burgdorferi.

Author information

  • 1Department of Medicine, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, NJ 07103, USA. schutzer@umdnj.edu

Abstract

Borrelia burgdorferi is a causative agent of Lyme disease in North America and Eurasia. The first complete genome sequence of B. burgdorferi strain 31, available for more than a decade, has assisted research on the pathogenesis of Lyme disease. Because a single genome sequence is not sufficient to understand the relationship between genotypic and geographic variation and disease phenotype, we determined the whole-genome sequences of 13 additional B. burgdorferi isolates that span the range of natural variation. These sequences should allow improved understanding of pathogenesis and provide a foundation for novel detection, diagnosis, and prevention strategies.

PMID:
20935092
[PubMed - indexed for MEDLINE]
PMCID:
PMC3028687
Free PMC Article
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