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Results: 1 to 20 of 86

1.

Characterisation of a melamino nitroheterocycle as a potential lead for the treatment of human African trypanosomiasis.

Giordani F, Buschini A, Baliani A, Kaiser M, Brun R, Barrett MP, Pellacani C, Poli P, Gilbert IH.

Antimicrob Agents Chemother. 2014 Jul 14. pii: AAC.01449-13. [Epub ahead of print]

PMID:
25022590
[PubMed - as supplied by publisher]
2.

Pharmacokinetic comparison to determine the mechanisms underlying the differential efficacies of cationic diamidines against first- and second-stage human African trypanosomiasis.

Yang S, Wenzler T, Miller PN, Wu H, Boykin DW, Brun R, Wang MZ.

Antimicrob Agents Chemother. 2014 Jul;58(7):4064-74. doi: 10.1128/AAC.02605-14. Epub 2014 May 5.

PMID:
24798280
[PubMed - in process]
3.

Binding to large enzyme pockets: small-molecule inhibitors of trypanothione reductase.

Persch E, Bryson S, Todoroff NK, Eberle C, Thelemann J, Dirdjaja N, Kaiser M, Weber M, Derbani H, Brun R, Schneider G, Pai EF, Krauth-Siegel RL, Diederich F.

ChemMedChem. 2014 Aug;9(8):1880-91. doi: 10.1002/cmdc.201402032. Epub 2014 Apr 30.

PMID:
24788386
[PubMed - in process]
4.

Antitrypanosomal structure-activity-relationship study of synthetic cynaropicrin derivatives.

Usuki T, Sato M, Hara S, Yoshimoto Y, Kondo R, Zimmermann S, Kaiser M, Brun R, Hamburger M, Adams M.

Bioorg Med Chem Lett. 2014 Feb 1;24(3):794-8. doi: 10.1016/j.bmcl.2013.12.099. Epub 2014 Jan 2.

PMID:
24433861
[PubMed - in process]
5.

Antitrypanosomal isoflavan quinones from Abrus precatorius.

Hata Y, Ebrahimi SN, De Mieri M, Zimmermann S, Mokoka T, Naidoo D, Fouche G, Maharaj V, Kaiser M, Brun R, Potterat O, Hamburger M.

Fitoterapia. 2014 Mar;93:81-7. doi: 10.1016/j.fitote.2013.12.015. Epub 2013 Dec 29.

PMID:
24382449
[PubMed - in process]
6.

Substituted 2-phenylimidazopyridines: a new class of drug leads for human African trypanosomiasis.

Tatipaka HB, Gillespie JR, Chatterjee AK, Norcross NR, Hulverson MA, Ranade RM, Nagendar P, Creason SA, McQueen J, Duster NA, Nagle A, Supek F, Molteni V, Wenzler T, Brun R, Glynne R, Buckner FS, Gelb MH.

J Med Chem. 2014 Feb 13;57(3):828-35. doi: 10.1021/jm401178t. Epub 2014 Jan 15.

PMID:
24354316
[PubMed - indexed for MEDLINE]
7.

In Silico prediction and experimental evaluation of furanoheliangolide sesquiterpene lactones as potent agents against Trypanosoma brucei rhodesiense.

Schmidt TJ, Da Costa FB, Lopes NP, Kaiser M, Brun R.

Antimicrob Agents Chemother. 2014;58(1):325-32. doi: 10.1128/AAC.01263-13. Epub 2013 Oct 28.

PMID:
24165182
[PubMed - in process]
Free PMC Article
8.

Aquaporin 2 mutations in Trypanosoma brucei gambiense field isolates correlate with decreased susceptibility to pentamidine and melarsoprol.

Graf FE, Ludin P, Wenzler T, Kaiser M, Brun R, Pyana PP, Büscher P, de Koning HP, Horn D, Mäser P.

PLoS Negl Trop Dis. 2013 Oct 10;7(10):e2475. doi: 10.1371/journal.pntd.0002475. eCollection 2013.

PMID:
24130910
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Cynaropicrin targets the trypanothione redox system in Trypanosoma brucei.

Zimmermann S, Oufir M, Leroux A, Krauth-Siegel RL, Becker K, Kaiser M, Brun R, Hamburger M, Adams M.

Bioorg Med Chem. 2013 Nov 15;21(22):7202-9. doi: 10.1016/j.bmc.2013.08.052. Epub 2013 Sep 5.

PMID:
24080104
[PubMed - indexed for MEDLINE]
10.

Pharmacokinetics, Trypanosoma brucei gambiense efficacy, and time of drug action of DB829, a preclinical candidate for treatment of second-stage human African trypanosomiasis.

Wenzler T, Yang S, Braissant O, Boykin DW, Brun R, Wang MZ.

Antimicrob Agents Chemother. 2013 Nov;57(11):5330-43. doi: 10.1128/AAC.00398-13. Epub 2013 Aug 19.

PMID:
23959303
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Synthesis and antiprotozoal activities of benzyl phenyl ether diamidine derivatives.

Patrick DA, Bakunov SA, Bakunova SM, Jones SK, Wenzler T, Barszcz T, Kumar A, Boykin DW, Werbovetz KA, Brun R, Tidwell RR.

Eur J Med Chem. 2013 Sep;67:310-24. doi: 10.1016/j.ejmech.2013.06.033. Epub 2013 Jun 25.

PMID:
23871911
[PubMed - indexed for MEDLINE]
12.

Safety, pharmacokinetic, and efficacy studies of oral DB868 in a first stage vervet monkey model of human African trypanosomiasis.

Thuita JK, Wolf KK, Murilla GA, Liu Q, Mutuku JN, Chen Y, Bridges AS, Mdachi RE, Ismail MA, Ching S, Boykin DW, Hall JE, Tidwell RR, Paine MF, Brun R, Wang MZ.

PLoS Negl Trop Dis. 2013 Jun 6;7(6):e2230. doi: 10.1371/journal.pntd.0002230. Print 2013.

PMID:
23755309
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Optimization of the electrophile of chloronitrobenzamide leads active against Trypanosoma brucei.

Hwang JY, Smithson DC, Holbrook G, Zhu F, Connelly MC, Kaiser M, Brun R, Kiplin Guy R.

Bioorg Med Chem Lett. 2013 Jul 15;23(14):4127-31. doi: 10.1016/j.bmcl.2013.05.049. Epub 2013 May 23.

PMID:
23746473
[PubMed - indexed for MEDLINE]
14.

Optimization of chloronitrobenzamides (CNBs) as therapeutic leads for human African trypanosomiasis (HAT).

Hwang JY, Smithson D, Zhu F, Holbrook G, Connelly MC, Kaiser M, Brun R, Guy RK.

J Med Chem. 2013 Apr 11;56(7):2850-60. doi: 10.1021/jm301687p. Epub 2013 Mar 26.

PMID:
23484493
[PubMed - indexed for MEDLINE]
15.

Agrochemicals against malaria, sleeping sickness, leishmaniasis and Chagas disease.

Witschel M, Rottmann M, Kaiser M, Brun R.

PLoS Negl Trop Dis. 2012;6(10):e1805. doi: 10.1371/journal.pntd.0001805. Epub 2012 Oct 25.

PMID:
23145187
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Pharmacology of DB844, an orally active aza analogue of pafuramidine, in a monkey model of second stage human African trypanosomiasis.

Thuita JK, Wang MZ, Kagira JM, Denton CL, Paine MF, Mdachi RE, Murilla GA, Ching S, Boykin DW, Tidwell RR, Hall JE, Brun R.

PLoS Negl Trop Dis. 2012;6(7):e1734. doi: 10.1371/journal.pntd.0001734. Epub 2012 Jul 24.

PMID:
22848769
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Isothermal microcalorimetry, a new tool to monitor drug action against Trypanosoma brucei and Plasmodium falciparum.

Wenzler T, Steinhuber A, Wittlin S, Scheurer C, Brun R, Trampuz A.

PLoS Negl Trop Dis. 2012;6(6):e1668. doi: 10.1371/journal.pntd.0001668. Epub 2012 Jun 5.

PMID:
22679520
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Antiparasitic agents: new drugs on the horizon.

Mäser P, Wittlin S, Rottmann M, Wenzler T, Kaiser M, Brun R.

Curr Opin Pharmacol. 2012 Oct;12(5):562-6. doi: 10.1016/j.coph.2012.05.001. Epub 2012 May 29. Review.

PMID:
22652215
[PubMed - indexed for MEDLINE]
19.

Human African trypanosomiasis.

Brun R, Blum J.

Infect Dis Clin North Am. 2012 Jun;26(2):261-73. doi: 10.1016/j.idc.2012.03.003. Epub 2012 Apr 17.

PMID:
22632638
[PubMed - indexed for MEDLINE]
20.

The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases - part II.

Schmidt TJ, Khalid SA, Romanha AJ, Alves TM, Biavatti MW, Brun R, Da Costa FB, de Castro SL, Ferreira VF, de Lacerda MV, Lago JH, Leon LL, Lopes NP, das Neves Amorim RC, Niehues M, Ogungbe IV, Pohlit AM, Scotti MT, Setzer WN, de N C Soeiro M, Steindel M, Tempone AG.

Curr Med Chem. 2012;19(14):2176-228. Review.

PMID:
22414104
[PubMed - indexed for MEDLINE]

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