Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Results: 1 to 20 of 60

1.

Inhibition of Bfl-1 with N-aryl maleimides.

Cashman JR, MacDonald M, Ghirmai S, Okolotowicz KJ, Sergienko E, Brown B, Garcia X, Zhai D, Dahl R, Reed JC.

Bioorg Med Chem Lett. 2010 Nov 15;20(22):6560-4. doi: 10.1016/j.bmcl.2010.09.046. Epub 2010 Sep 21.

PMID:
20933419
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Towards patient-based cancer therapeutics.

Cancer Target Discovery and Development Network, Schreiber SL, Shamji AF, Clemons PA, Hon C, Koehler AN, Munoz B, Palmer M, Stern AM, Wagner BK, Powers S, Lowe SW, Guo X, Krasnitz A, Sawey ET, Sordella R, Stein L, Trotman LC, Califano A, Dalla-Favera R, Ferrando A, Iavarone A, Pasqualucci L, Silva J, Stockwell BR, Hahn WC, Chin L, DePinho RA, Boehm JS, Gopal S, Huang A, Root DE, Weir BA, Gerhard DS, Zenklusen JC, Roth MG, White MA, Minna JD, MacMillan JB, Posner BA.

Nat Biotechnol. 2010 Sep;28(9):904-6. doi: 10.1038/nbt0910-904. No abstract available.

PMID:
20829823
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

A small-molecule inducer of the antioxidant response element.

Hur W, Sun Z, Jiang T, Mason DE, Peters EC, Zhang DD, Luesch H, Schultz PG, Gray NS.

Chem Biol. 2010 May 28;17(5):537-47. doi: 10.1016/j.chembiol.2010.03.013.

PMID:
20534351
[PubMed - indexed for MEDLINE]
Free Article
4.

Apogossypol derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.

Wei J, Kitada S, Rega MF, Stebbins JL, Zhai D, Cellitti J, Yuan H, Emdadi A, Dahl R, Zhang Z, Yang L, Reed JC, Pellecchia M.

J Med Chem. 2009 Jul 23;52(14):4511-23. doi: 10.1021/jm900472s.

PMID:
19555126
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Completing the family portrait of the anti-apoptotic Bcl-2 proteins: crystal structure of human Bfl-1 in complex with Bim.

Herman MD, Nyman T, Welin M, Lehtiö L, Flodin S, Trésaugues L, Kotenyova T, Flores A, Nordlund P.

FEBS Lett. 2008 Oct 29;582(25-26):3590-4. doi: 10.1016/j.febslet.2008.09.028. Epub 2008 Sep 21.

PMID:
18812174
[PubMed - indexed for MEDLINE]
Free Article
6.

Bcl-2 inhibitors: small molecules with a big impact on cancer therapy.

Vogler M, Dinsdale D, Dyer MJ, Cohen GM.

Cell Death Differ. 2009 Mar;16(3):360-7. doi: 10.1038/cdd.2008.137. Epub 2008 Sep 19. Review.

PMID:
18806758
[PubMed - indexed for MEDLINE]
Free Article
7.

Non-peptidic small molecule inhibitors against Bcl-2 for cancer therapy.

Azmi AS, Mohammad RM.

J Cell Physiol. 2009 Jan;218(1):13-21. doi: 10.1002/jcp.21567. Review.

PMID:
18767026
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins.

Zhai D, Jin C, Shiau CW, Kitada S, Satterthwait AC, Reed JC.

Mol Cancer Ther. 2008 Jun;7(6):1639-46. doi: 10.1158/1535-7163.MCT-07-2373.

PMID:
18566235
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Structural plasticity underpins promiscuous binding of the prosurvival protein A1.

Smits C, Czabotar PE, Hinds MG, Day CL.

Structure. 2008 May;16(5):818-29. doi: 10.1016/j.str.2008.02.009.

PMID:
18462686
[PubMed - indexed for MEDLINE]
Free Article
10.

ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor.

Tse C, Shoemaker AR, Adickes J, Anderson MG, Chen J, Jin S, Johnson EF, Marsh KC, Mitten MJ, Nimmer P, Roberts L, Tahir SK, Xiao Y, Yang X, Zhang H, Fesik S, Rosenberg SH, Elmore SW.

Cancer Res. 2008 May 1;68(9):3421-8. doi: 10.1158/0008-5472.CAN-07-5836.

PMID:
18451170
[PubMed - indexed for MEDLINE]
Free Article
11.

Chelerythrine induces apoptosis through a Bax/Bak-independent mitochondrial mechanism.

Wan KF, Chan SL, Sukumaran SK, Lee MC, Yu VC.

J Biol Chem. 2008 Mar 28;283(13):8423-33. doi: 10.1074/jbc.M707687200. Epub 2008 Jan 29.

PMID:
18230621
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).

Kitada S, Kress CL, Krajewska M, Jia L, Pellecchia M, Reed JC.

Blood. 2008 Mar 15;111(6):3211-9. doi: 10.1182/blood-2007-09-113647. Epub 2008 Jan 17.

PMID:
18202226
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Proapoptotic BH3-only BCL-2 family protein BIM connects death signaling from epidermal growth factor receptor inhibition to the mitochondrion.

Deng J, Shimamura T, Perera S, Carlson NE, Cai D, Shapiro GI, Wong KK, Letai A.

Cancer Res. 2007 Dec 15;67(24):11867-75.

PMID:
18089817
[PubMed - indexed for MEDLINE]
Free Article
14.

Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics.

Cragg MS, Kuroda J, Puthalakath H, Huang DC, Strasser A.

PLoS Med. 2007 Oct;4(10):1681-89; discussion 1690.

PMID:
17973573
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations.

Costa DB, Halmos B, Kumar A, Schumer ST, Huberman MS, Boggon TJ, Tenen DG, Kobayashi S.

PLoS Med. 2007 Oct;4(10):1669-79; discussion 1680.

PMID:
17973572
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas.

Gong Y, Somwar R, Politi K, Balak M, Chmielecki J, Jiang X, Pao W.

PLoS Med. 2007 Oct 9;4(10):e294.

PMID:
17927446
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents.

Deng J, Carlson N, Takeyama K, Dal Cin P, Shipp M, Letai A.

Cancer Cell. 2007 Aug;12(2):171-85.

PMID:
17692808
[PubMed - indexed for MEDLINE]
Free Article
18.

Downregulation of Bfl-1 protein expression sensitizes malignant B cells to apoptosis.

Brien G, Trescol-Biemont MC, Bonnefoy-Bérard N.

Oncogene. 2007 Aug 23;26(39):5828-32. Epub 2007 Mar 12.

PMID:
17353899
[PubMed - indexed for MEDLINE]
19.

Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma.

Trudel S, Li ZH, Rauw J, Tiedemann RE, Wen XY, Stewart AK.

Blood. 2007 Jun 15;109(12):5430-8. Epub 2007 Mar 1.

PMID:
17332241
[PubMed - indexed for MEDLINE]
Free Article
20.

The Bcl-2 apoptotic switch in cancer development and therapy.

Adams JM, Cory S.

Oncogene. 2007 Feb 26;26(9):1324-37. Review.

PMID:
17322918
[PubMed - indexed for MEDLINE]
Free PMC Article

Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Write to the Help Desk