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Science. 2010 Oct 22;330(6003):512-4. doi: 10.1126/science.1195755.

Widespread divergence between incipient Anopheles gambiae species revealed by whole genome sequences.

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  • 1Division of Cell and Molecular Biology, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.

Abstract

The Afrotropical mosquito Anopheles gambiae sensu stricto, a major vector of malaria, is currently undergoing speciation into the M and S molecular forms. These forms have diverged in larval ecology and reproductive behavior through unknown genetic mechanisms, despite considerable levels of hybridization. Previous genome-wide scans using gene-based microarrays uncovered divergence between M and S that was largely confined to gene-poor pericentromeric regions, prompting a speciation-with-ongoing-gene-flow model that implicated only about 3% of the genome near centromeres in the speciation process. Here, based on the complete M and S genome sequences, we report widespread and heterogeneous genomic divergence inconsistent with appreciable levels of interform gene flow, suggesting a more advanced speciation process and greater challenges to identify genes critical to initiating that process.

PMID:
20966253
[PubMed - indexed for MEDLINE]
PMCID:
PMC3674514
Free PMC Article

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