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Virchows Arch. 2003 Jul;443(1):93-7. Epub 2003 May 13.

CD31 staining in epithelioid sarcoma.

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  • 1Department of Pathology, Erasmus Medical Center, PO Box 1738, 3000 DR Rotterdam, Netherlands.


We report an unusual case of epithelioid sarcoma. The tumour occurred in the finger of a 27-year-old female. The clinical history, histology and the electron microscopy of the lesion were typical for epithelioid sarcoma. However, immunohistochemical analysis showed strong membranous CD31 staining, a finding hitherto not described. All other robust vascular markers, including factor-VIII-related antigen (FVIIIrag) were negative. The findings were compared with the available literature data, leading us to conclude that there is insufficient evidence for endothelial derivation of epithelioid sarcoma, but in the differential diagnosis with vascular tumours CD31 may stain and to rule out angiosarcoma FVIIIrag is a useful antibody.

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