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Results: 1 to 20 of 90

1.

Interrupting synoviolin play at the ER: a plausible action to elevate mitochondrial energetics and silence obesity.

Soustek MS, Puigserver P.

EMBO J. 2015 Apr 15;34(8):981-3. doi: 10.15252/embj.201591240. Epub 2015 Mar 3.

PMID:
25736377
2.

Adenosine activates thermogenic adipocytes.

Rines AK, Verdeguer F, Puigserver P.

Cell Res. 2015 Feb;25(2):155-6. doi: 10.1038/cr.2014.157. Epub 2014 Dec 2.

PMID:
25449131
3.

Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation.

Chow JD, Lawrence RT, Healy ME, Dominy JE, Liao JA, Breen DS, Byrne FL, Kenwood BM, Lackner C, Okutsu S, Mas VR, Caldwell SH, Tomsig JL, Cooney GJ, Puigserver PB, Turner N, James DE, Villén J, Hoehn KL.

Mol Metab. 2014 Mar 12;3(4):419-31. doi: 10.1016/j.molmet.2014.02.004. eCollection 2014 Jul.

4.

Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression.

Lee Y, Dominy JE, Choi YJ, Jurczak M, Tolliday N, Camporez JP, Chim H, Lim JH, Ruan HB, Yang X, Vazquez F, Sicinski P, Shulman GI, Puigserver P.

Nature. 2014 Jun 26;510(7506):547-51. doi: 10.1038/nature13267. Epub 2014 May 25.

5.

Targeting mitochondrial oxidative metabolism in melanoma causes metabolic compensation through glucose and glutamine utilization.

Lim JH, Luo C, Vazquez F, Puigserver P.

Cancer Res. 2014 Jul 1;74(13):3535-45. doi: 10.1158/0008-5472.CAN-13-2893-T. Epub 2014 May 8.

6.

Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.

Kraus D, Yang Q, Kong D, Banks AS, Zhang L, Rodgers JT, Pirinen E, Pulinilkunnil TC, Gong F, Wang YC, Cen Y, Sauve AA, Asara JM, Peroni OD, Monia BP, Bhanot S, Alhonen L, Puigserver P, Kahn BB.

Nature. 2014 Apr 10;508(7495):258-62. doi: 10.1038/nature13198.

7.

USP7 attenuates hepatic gluconeogenesis through modulation of FoxO1 gene promoter occupancy.

Hall JA, Tabata M, Rodgers JT, Puigserver P.

Mol Endocrinol. 2014 Jun;28(6):912-24. doi: 10.1210/me.2013-1420. Epub 2014 Apr 2.

8.

Decreased genetic dosage of hepatic Yin Yang 1 causes diabetic-like symptoms.

Verdeguer F, Blättler SM, Cunningham JT, Hall JA, Chim H, Puigserver P.

Mol Endocrinol. 2014 Mar;28(3):308-16. doi: 10.1210/me.2013-1173. Epub 2014 Jan 27.

9.

Cdc2-like kinase 2 suppresses hepatic fatty acid oxidation and ketogenesis through disruption of the PGC-1α and MED1 complex.

Tabata M, Rodgers JT, Hall JA, Lee Y, Jedrychowski MP, Gygi SP, Puigserver P.

Diabetes. 2014 May;63(5):1519-32. doi: 10.2337/db13-1304. Epub 2014 Jan 23.

10.

In vivo measurement of the acetylation state of sirtuin substrates as a proxy for sirtuin activity.

Dominy J, Puigserver P, Cantó C.

Methods Mol Biol. 2013;1077:217-37. doi: 10.1007/978-1-62703-637-5_15.

PMID:
24014410
11.

Mitochondrial biogenesis through activation of nuclear signaling proteins.

Dominy JE, Puigserver P.

Cold Spring Harb Perspect Biol. 2013 Jul 1;5(7). pii: a015008. doi: 10.1101/cshperspect.a015008. Review.

12.

The sirtuin family's role in aging and age-associated pathologies.

Hall JA, Dominy JE, Lee Y, Puigserver P.

J Clin Invest. 2013 Mar;123(3):973-9. doi: 10.1172/JCI64094. Epub 2013 Mar 1. Review.

13.

PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress.

Vazquez F, Lim JH, Chim H, Bhalla K, Girnun G, Pierce K, Clish CB, Granter SR, Widlund HR, Spiegelman BM, Puigserver P.

Cancer Cell. 2013 Mar 18;23(3):287-301. doi: 10.1016/j.ccr.2012.11.020. Epub 2013 Feb 14.

14.

Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1α complex.

Lim JH, Gerhart-Hines Z, Dominy JE, Lee Y, Kim S, Tabata M, Xiang YK, Puigserver P.

J Biol Chem. 2013 Mar 8;288(10):7117-26. doi: 10.1074/jbc.M112.415729. Epub 2013 Jan 17.

15.

The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis.

Dominy JE Jr, Lee Y, Jedrychowski MP, Chim H, Jurczak MJ, Camporez JP, Ruan HB, Feldman J, Pierce K, Mostoslavsky R, Denu JM, Clish CB, Yang X, Shulman GI, Gygi SP, Puigserver P.

Mol Cell. 2012 Dec 28;48(6):900-13. doi: 10.1016/j.molcel.2012.09.030. Epub 2012 Nov 8.

16.

TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis.

Ye L, Kleiner S, Wu J, Sah R, Gupta RK, Banks AS, Cohen P, Khandekar MJ, Boström P, Mepani RJ, Laznik D, Kamenecka TM, Song X, Liedtke W, Mootha VK, Puigserver P, Griffin PR, Clapham DE, Spiegelman BM.

Cell. 2012 Sep 28;151(1):96-110. doi: 10.1016/j.cell.2012.08.034.

17.

A metabolic prosurvival role for PML in breast cancer.

Carracedo A, Weiss D, Leliaert AK, Bhasin M, de Boer VC, Laurent G, Adams AC, Sundvall M, Song SJ, Ito K, Finley LS, Egia A, Libermann T, Gerhart-Hines Z, Puigserver P, Haigis MC, Maratos-Flier E, Richardson AL, Schafer ZT, Pandolfi PP.

J Clin Invest. 2012 Sep;122(9):3088-100. doi: 10.1172/JCI62129. Epub 2012 Aug 13.

18.

Defective mitochondrial morphology and bioenergetic function in mice lacking the transcription factor Yin Yang 1 in skeletal muscle.

Blättler SM, Verdeguer F, Liesa M, Cunningham JT, Vogel RO, Chim H, Liu H, Romanino K, Shirihai OS, Vazquez F, Rüegg MA, Shi Y, Puigserver P.

Mol Cell Biol. 2012 Aug;32(16):3333-46. doi: 10.1128/MCB.00337-12. Epub 2012 Jun 18.

19.

Yin Yang 1 deficiency in skeletal muscle protects against rapamycin-induced diabetic-like symptoms through activation of insulin/IGF signaling.

Blättler SM, Cunningham JT, Verdeguer F, Chim H, Haas W, Liu H, Romanino K, Rüegg MA, Gygi SP, Shi Y, Puigserver P.

Cell Metab. 2012 Apr 4;15(4):505-17. doi: 10.1016/j.cmet.2012.03.008.

20.

Nutrient-dependent acetylation controls basic regulatory metabolic switches and cellular reprogramming.

Dominy JE, Gerhart-Hines Z, Puigserver P.

Cold Spring Harb Symp Quant Biol. 2011;76:203-9. doi: 10.1101/sqb.2012.76.010843. Epub 2012 Feb 27. Review.

PMID:
22371372
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