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Results: 1 to 20 of 330

1.

Small heat shock protein 20 (Hsp20) facilitates nuclear import of protein kinase D 1 (PKD1) during cardiac hypertrophy.

Sin YY, Martin TP, Wills L, Currie S, Baillie GS.

Cell Commun Signal. 2015 Mar 7;13(1):16. doi: 10.1186/s12964-015-0094-x.

2.

A novel PKD1 variant demonstrates a disease-modifying role in trans with a truncating PKD1 mutation in patients with Autosomal Dominant Polycystic Kidney Disease.

Ali H, Hussain N, Naim M, Zayed M, Al-Mulla F, Kehinde EO, Seaburg LM, Sundsbak JL, Harris PC.

BMC Nephrol. 2015 Mar 1;16:26. doi: 10.1186/s12882-015-0015-7.

3.

PKD1 mono-allelic knockout is sufficient to trigger renal cystogenesis in a mini-pig model.

He J, Li Q, Fang S, Guo Y, Liu T, Ye J, Yu Z, Zhang R, Zhao Y, Hu X, Bai X, Chen X, Li N.

Int J Biol Sci. 2015 Feb 10;11(4):361-9. doi: 10.7150/ijbs.10858. eCollection 2015.

4.

PKD1 Protein Is Involved in Reactive Oxygen Species-mediated Mitochondrial Depolarization in Cooperation with Protein Kinase Cδ (PKCδ).

Zhang T, Sell P, Braun U, Leitges M.

J Biol Chem. 2015 Apr 17;290(16):10472-85. doi: 10.1074/jbc.M114.619148. Epub 2015 Mar 10.

PMID:
25759386
5.

Splicing defects caused by exonic mutations in PKD1 as a new mechanism of pathogenesis in autosomal dominant polycystic kidney disease.

Claverie-Martin F, Gonzalez-Paredes FJ, Ramos-Trujillo E.

RNA Biol. 2015 Apr 3;12(4):369-74. doi: 10.1080/15476286.2015.1014291.

PMID:
25757501
6.

PKD1 is downregulated in non-small cell lung cancer and mediates the feedback inhibition of mTORC1-S6K1 axis in response to phorbol ester.

Ni Y, Wang L, Zhang J, Pang Z, Liu Q, Du J.

Int J Biochem Cell Biol. 2015 Mar;60:34-42. doi: 10.1016/j.biocel.2014.12.018. Epub 2015 Jan 9.

PMID:
25578563
7.

Modification of PCR conditions and design of exon-specific primers for the efficient molecular diagnosis of PKD1 mutations.

Liu W, Chen M, Wei J, He W, Li Z, Sun X, Shi Y.

Kidney Blood Press Res. 2014;39(6):536-45. doi: 10.1159/000368464. Epub 2014 Nov 30.

PMID:
25531466
8.

Genkwadaphnin induces IFN-γ via PKD1/NF-κB/STAT1 dependent pathway in NK-92 cells.

Kang HB, Ahn KS, Oh SR, Kim JW.

PLoS One. 2014 Dec 17;9(12):e115146. doi: 10.1371/journal.pone.0115146. eCollection 2014.

9.

Identification of novel PKD1 and PKD2 mutations in Korean patients with autosomal dominant polycystic kidney disease.

Choi R, Park HC, Lee K, Lee MG, Kim JW, Ki CS, Hwang YH, Ahn C.

BMC Med Genet. 2014 Dec 10;15(1):129. doi: 10.1186/s12881-014-0129-y.

10.

Identification of Biomarkers for PKD1 Using Urinary Exosomes.

Hogan MC, Bakeberg JL, Gainullin VG, Irazabal MV, Harmon AJ, Lieske JC, Charlesworth MC, Johnson KL, Madden BJ, Zenka RM, McCormick DJ, Sundsbak JL, Heyer CM, Torres VE, Harris PC, Ward CJ.

J Am Soc Nephrol. 2014 Dec 4. pii: ASN.2014040354. [Epub ahead of print]

PMID:
25475747
11.

Inhibiting heat shock protein 90 (HSP90) limits the formation of liver cysts induced by conditional deletion of Pkd1 in mice.

Smithline ZB, Nikonova AS, Hensley HH, Cai KQ, Egleston BL, Proia DA, Seeger-Nukpezah T, Golemis EA.

PLoS One. 2014 Dec 4;9(12):e114403. doi: 10.1371/journal.pone.0114403. eCollection 2014.

12.

L1 modulates PKD1 phosphorylation in cerebellar granule neurons.

Chen SX, Hu CL, Liao YH, Zhao WJ.

Neurosci Lett. 2015 Jan 1;584:331-6. doi: 10.1016/j.neulet.2014.11.012. Epub 2014 Nov 13.

PMID:
25445362
13.

Scattered Deletion of PKD1 in Kidneys Causes a Cystic Snowball Effect and Recapitulates Polycystic Kidney Disease.

Leonhard WN, Zandbergen M, Veraar K, van den Berg S, van der Weerd L, Breuning M, de Heer E, Peters DJ.

J Am Soc Nephrol. 2014 Oct 31. pii: ASN.2013080864. [Epub ahead of print]

PMID:
25361818
14.

Diagnosis of autosomal dominant polycystic kidney disease using efficient PKD1 and PKD2 targeted next-generation sequencing.

Trujillano D, Bullich G, Ossowski S, Ballarín J, Torra R, Estivill X, Ars E.

Mol Genet Genomic Med. 2014 Sep;2(5):412-21. doi: 10.1002/mgg3.82. Epub 2014 May 23.

15.

PKD1 phosphorylation-dependent degradation of SNAIL by SCF-FBXO11 regulates epithelial-mesenchymal transition and metastasis.

Zheng H, Shen M, Zha YL, Li W, Wei Y, Blanco MA, Ren G, Zhou T, Storz P, Wang HY, Kang Y.

Cancer Cell. 2014 Sep 8;26(3):358-73. doi: 10.1016/j.ccr.2014.07.022.

PMID:
25203322
16.

Nedd9 restrains renal cystogenesis in Pkd1-/- mice.

Nikonova AS, Plotnikova OV, Serzhanova V, Efimov A, Bogush I, Cai KQ, Hensley HH, Egleston BL, Klein-Szanto A, Seeger-Nukpezah T, Golemis EA.

Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12859-64. doi: 10.1073/pnas.1405362111. Epub 2014 Aug 19.

17.

The p38 MAPK-regulated PKD1/CREB/Bcl-2 pathway contributes to selenite-induced colorectal cancer cell apoptosis in vitro and in vivo.

Hui K, Yang Y, Shi K, Luo H, Duan J, An J, Wu P, Ci Y, Shi L, Xu C.

Cancer Lett. 2014 Nov 1;354(1):189-99. doi: 10.1016/j.canlet.2014.08.009. Epub 2014 Aug 12.

18.

An autopsy case of subarachnoid hemorrhage due to ruptured cerebral aneurysm associated with polycystic kidney disease caused by a novel PKD1 mutation.

Soejima M, Sugita Y, Koda Y.

Forensic Sci Int. 2014 Sep;242:e18-21. doi: 10.1016/j.forsciint.2014.06.029. Epub 2014 Jul 2.

PMID:
25022697
19.

Tolvaptan plus pasireotide shows enhanced efficacy in a PKD1 model.

Hopp K, Hommerding CJ, Wang X, Ye H, Harris PC, Torres VE.

J Am Soc Nephrol. 2015 Jan;26(1):39-47. doi: 10.1681/ASN.2013121312. Epub 2014 Jul 3.

PMID:
24994926
20.

Defective pre-mRNA splicing in PKD1 due to presumed missense and synonymous mutations causing autosomal dominant polycystic disease.

Gonzalez-Paredes FJ, Ramos-Trujillo E, Claverie-Martin F.

Gene. 2014 Aug 10;546(2):243-9. doi: 10.1016/j.gene.2014.06.004. Epub 2014 Jun 4.

PMID:
24907393
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