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pH-sensitive membrane peptides (pHLIPs) as a novel class of delivery agents.
Andreev OA, Engelman DM, Reshetnyak YK. Andreev OA, et al. Mol Membr Biol. 2010 Oct;27(7):341-52. doi: 10.3109/09687688.2010.509285. Epub 2010 Oct 13. Mol Membr Biol. 2010. PMID: 20939768 Free PMC article. Review.
Abstract Here we review a novel class of delivery vehicles based on pH-sensitive, moderately polar membrane peptides, which we call pH (Low) Insertion Peptides (pHLIPs), that target cells located in the acidic environ …
Abstract Here we review a novel class of delivery vehicles based on pH-sensitive, moderately polar mem
Novel pH-Sensitive Cyclic Peptides.
Weerakkody D, Moshnikova A, El-Sayed NS, Adochite RC, Slaybaugh G, Golijanin J, Tiwari RK, Andreev OA, Parang K, Reshetnyak YK. Weerakkody D, et al. Sci Rep. 2016 Aug 12;6:31322. doi: 10.1038/srep31322. Sci Rep. 2016. PMID: 27515582 Free PMC article.
A series of cyclic peptides containing a number of tryptophan (W) and glutamic acid (E) residues were synthesized and evaluated as pH-sensitive agents for targeting of acidic tissue and pH-dependent cytoplasmic delivery of molecules. ...We have …
A series of cyclic peptides containing a number of tryptophan (W) and glutamic acid (E) residues were synthesized and evaluated as …