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iRhom2 mutation leads to aberrant hair follicle differentiation in mice.
Leilei Y, Bing L, Yang L, Shaoxia W, Yuan X, Dongping W, Huahu Y, Shichen S, Guangzhou Z, Ruiyun P, Lin Z, Wenlong L. Leilei Y, et al. PLoS One. 2014 Dec 29;9(12):e115114. doi: 10.1371/journal.pone.0115114. eCollection 2014. PLoS One. 2014. PMID: 25546423 Free PMC article.
Further examination found decreased hair matrix proliferation and aberrant hair shaft and inner root sheath differentiation in iRhom2Uncv/Uncv mutant hair follicles. iRhom2 is required for the maturation of TACE. ...This study identifies …
Further examination found decreased hair matrix proliferation and aberrant hair shaft and inner root sheath differen
iRhom2 (Uncv) mutation blocks bulge stem cells assuming the fate of hair follicle.
Yang L, Li W, Liu B, Wang S, Zeng L, Zhang C, Li Y. Yang L, et al. Arch Dermatol Res. 2016 Sep;308(7):503-10. doi: 10.1007/s00403-016-1663-6. Epub 2016 Jul 8. Arch Dermatol Res. 2016. PMID: 27393687
In the previous study, we found that the iRhom2 (Uncv) mutation in N-terminal cytoplasmic domain-encoding region (iRhom2 (Uncv) ) leads to aberrant hair shaft and inner root sheath differentiation, thus results in a hairless phenot …
In the previous study, we found that the iRhom2 (Uncv) mutation in N-terminal cytoplasmic domain-encoding region (iRhom2