Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 5
1994 3
1995 1
1996 1
1997 2
1998 4
1999 10
2000 15
2001 20
2002 26
2003 35
2004 29
2005 33
2006 35
2007 36
2008 31
2009 50
2010 55
2011 77
2012 68
2013 83
2014 103
2015 140
2016 140
2017 143
2018 143
2019 166
2020 193
2021 214
2022 176
2023 148
2024 53

Text availability

Article attribute

Article type

Publication date

Search Results

2,012 results

Results by year

Filters applied: . Clear all
Page 1
CXCL13-CXCR5 axis: Regulation in inflammatory diseases and cancer.
Wang B, Wang M, Ao D, Wei X. Wang B, et al. Biochim Biophys Acta Rev Cancer. 2022 Sep;1877(5):188799. doi: 10.1016/j.bbcan.2022.188799. Epub 2022 Sep 11. Biochim Biophys Acta Rev Cancer. 2022. PMID: 36103908 Free article. Review.
In this review, we discussed the functional mechanisms of the CXCL13-CXCR5 axis under normal conditions, with special focus on its association with diseases. For certain refractory diseases, we emphasize the diagnostic and therapeutic role of CXCL13-CXCR5 axis....
In this review, we discussed the functional mechanisms of the CXCL13-CXCR5 axis under normal conditions, with special focus on its as …
Role of the CXCL13/CXCR5 Axis in Autoimmune Diseases.
Pan Z, Zhu T, Liu Y, Zhang N. Pan Z, et al. Front Immunol. 2022 Mar 4;13:850998. doi: 10.3389/fimmu.2022.850998. eCollection 2022. Front Immunol. 2022. PMID: 35309354 Free PMC article. Review.
CXCL13 is a B-cell chemokine produced mainly by mesenchymal lymphoid tissue organizer cells, follicular dendritic cells, and human T follicular helper cells. By binding to its receptor, CXCR5, CXCL13 plays an important role in lymphoid neogenesis, lymphoid organization, an …
CXCL13 is a B-cell chemokine produced mainly by mesenchymal lymphoid tissue organizer cells, follicular dendritic cells, and human T follicu …
Follicular CXCR5- expressing CD8(+) T cells curtail chronic viral infection.
He R, Hou S, Liu C, Zhang A, Bai Q, Han M, Yang Y, Wei G, Shen T, Yang X, Xu L, Chen X, Hao Y, Wang P, Zhu C, Ou J, Liang H, Ni T, Zhang X, Zhou X, Deng K, Chen Y, Luo Y, Xu J, Qi H, Wu Y, Ye L. He R, et al. Nature. 2016 Aug 2;537(7620):412-428. doi: 10.1038/nature19317. Nature. 2016. PMID: 27501245
These CXCR5(+) CD8(+) T cells were able to migrate into B-cell follicles, expressed lower levels of inhibitory receptors and exhibited more potent cytotoxicity than the CXCR5(-) [corrected] subset. ...The CXCR5(+) subset showed greater therapeutic pote …
These CXCR5(+) CD8(+) T cells were able to migrate into B-cell follicles, expressed lower levels of inhibitory receptors and e …
CXCL13/CXCR5 signaling axis in cancer.
Hussain M, Adah D, Tariq M, Lu Y, Zhang J, Liu J. Hussain M, et al. Life Sci. 2019 Jun 15;227:175-186. doi: 10.1016/j.lfs.2019.04.053. Epub 2019 Apr 23. Life Sci. 2019. PMID: 31026453 Review.
CXCL13/CXCR5 signaling axis makes pivotal contributions to the development and progression of several human cancers. In this review, we discuss how CXCL13/CXCR5 signaling modulates cancer cell ability to grow, proliferate, invade, and metastasize. ...
CXCL13/CXCR5 signaling axis makes pivotal contributions to the development and progression of several human cancers. In this review, …
CXCR5+ CD8 T Cells: Protective or Pathogenic?
Valentine KM, Hoyer KK. Valentine KM, et al. Front Immunol. 2019 Jun 18;10:1322. doi: 10.3389/fimmu.2019.01322. eCollection 2019. Front Immunol. 2019. PMID: 31275308 Free PMC article. Review.
CXCR5+ CD8 T cells maintain transcriptional and phenotypic features consistent with the CD8 T cell nomenclature of a non-exhausted, effector memory population. ...The existence of this novel CXCR5+ CD8 T cell subset in human and murine models of disease may provide …
CXCR5+ CD8 T cells maintain transcriptional and phenotypic features consistent with the CD8 T cell nomenclature of a non-exhausted, e …
Role of CXCR5(+) CD8(+) T cells in human hepatitis B virus infection.
Zhou J, He X, Ou Y, Peng S, Li D, Zhou Q, Fu J, Long Y, Tan Y. Zhou J, et al. J Viral Hepat. 2023 Aug;30(8):638-645. doi: 10.1111/jvh.13840. Epub 2023 May 2. J Viral Hepat. 2023. PMID: 37129474 Review.
In terms of gene composition, regulation of B cell action and function, CXCR5(+) CD8(+) T cells are similar to CXCR5(+) CD4(+) T follicular helper cells, while these cells are characterized by elevated programmed cell death 1 and cytotoxic-related proteins. CXCR5 …
In terms of gene composition, regulation of B cell action and function, CXCR5(+) CD8(+) T cells are similar to CXCR5(+) CD4(+) …
CXCL13 drives spinal astrocyte activation and neuropathic pain via CXCR5.
Jiang BC, Cao DL, Zhang X, Zhang ZJ, He LN, Li CH, Zhang WW, Wu XB, Berta T, Ji RR, Gao YJ. Jiang BC, et al. J Clin Invest. 2016 Feb;126(2):745-61. doi: 10.1172/JCI81950. Epub 2016 Jan 11. J Clin Invest. 2016. PMID: 26752644 Free PMC article.
Spinal overexpression of miR-186-5p decreased CXCL13 expression, alleviating neuropathic pain. Furthermore, SNL induced CXCR5 expression in spinal astrocytes, and neuropathic pain was abrogated in Cxcr5-/- mice. CXCR5 expression induced by SNL was required fo …
Spinal overexpression of miR-186-5p decreased CXCL13 expression, alleviating neuropathic pain. Furthermore, SNL induced CXCR5 express …
CXCR5(+)CD8(+) T cells: A Review of their Antibody Regulatory Functions and Clinical Correlations.
Elzein SM, Zimmerer JM, Han JL, Ringwald BA, Bumgardner GL. Elzein SM, et al. J Immunol. 2021 Jun 15;206(12):2775-2783. doi: 10.4049/jimmunol.2100082. J Immunol. 2021. PMID: 34602651 Free PMC article. Review.
In this review we provide an in-depth analysis of conflicting reports regarding the impact of CXCR5(+)CD8(+) T cells on antibody production and examine the data supporting a role for antibody-enhancement (B cell "helper") and antibody-downregulation (antibody-suppressor) b …
In this review we provide an in-depth analysis of conflicting reports regarding the impact of CXCR5(+)CD8(+) T cells on antibody prod …
CXCR5 down-regulation alleviates cognitive dysfunction in a mouse model of sepsis-associated encephalopathy: potential role of microglial autophagy and the p38MAPK/NF-kappaB/STAT3 signaling pathway.
Shen Y, Zhang Y, Du J, Jiang B, Shan T, Li H, Bao H, Si Y. Shen Y, et al. J Neuroinflammation. 2021 Oct 28;18(1):246. doi: 10.1186/s12974-021-02300-1. J Neuroinflammation. 2021. PMID: 34711216 Free PMC article.
The present study used a mouse model of SAE to examine whether CXCR5 down-regulation could attenuate cognitive deficits. METHODS: Sepsis was induced in adult male C57BL/6 J and CXCR5(-/-) mice by cecal ligation and puncture (CLP). ...Down-regulating CXCR5 can …
The present study used a mouse model of SAE to examine whether CXCR5 down-regulation could attenuate cognitive deficits. METHODS: Sep …
S-nitrosylation-mediated coupling of G-protein alpha-2 with CXCR5 induces Hippo/YAP-dependent diabetes-accelerated atherosclerosis.
Chao ML, Luo S, Zhang C, Zhou X, Zhou M, Wang J, Kong C, Chen J, Lin Z, Tang X, Sun S, Tang X, Chen H, Wang H, Wang D, Sun JP, Han Y, Xie L, Ji Y. Chao ML, et al. Nat Commun. 2021 Jul 22;12(1):4452. doi: 10.1038/s41467-021-24736-y. Nat Commun. 2021. PMID: 34294713 Free PMC article.
Furthermore, Cys-mutant GNAI2 refractory to S-nitrosylation abrogated GNAI2-CXCR5 coupling, alleviated atherosclerosis in diabetic mice, restored Hippo activity, and reduced endothelial inflammation. ...In conclusion, SNO-GNAI2 drives diabetes-accelerated atherosclerosis b …
Furthermore, Cys-mutant GNAI2 refractory to S-nitrosylation abrogated GNAI2-CXCR5 coupling, alleviated atherosclerosis in diabetic mi …
2,012 results

Searches related to "cxcr5"