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See also: CDK4 cyclin-dependent kinase 4 in the Gene database
cdk4 in Homo sapiens | Mus musculus | Rattus norvegicus | All 35 Gene records
Metformin suppresses growth of human head and neck squamous cell carcinoma via global inhibition of protein translation.
Sikka A, Kaur M, Agarwal C, Deep G, Agarwal R.
Cell Cycle. 2012 Apr 1;11(7):1374-82. doi: 10.4161/cc.19798. Epub 2012 Apr 1.
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Deregulation of the G1/S phase transition in cancer and squamous intraepithelial lesions of the uterine cervix: a case control study.
Arvanitis DA, Spandidos DA.
Oncol Rep. 2008 Oct;20(4):751-60.
The role of cyclins and cyclins inhibitors in the multistep process of HPV-associated cervical carcinoma.
Bahnassy AA, Zekri AR, Alam El-Din HM, Aboubakr AA, Kamel K, El-Sabah MT, Mokhtar NM.
J Egypt Natl Canc Inst. 2006 Dec;18(4):292-302.
The opioid growth factor (OGF)-OGF receptor axis uses the p16 pathway to inhibit head and neck cancer.
Cheng F, Zagon IS, Verderame MF, McLaughlin PJ.
Cancer Res. 2007 Nov 1;67(21):10511-8.
Analysis of exon 2 of MTS1 in HPV-positive and HPV-negative tumors of the head and neck region.
Fischer M.
Eur Arch Otorhinolaryngol. 2007 Jul;264(7):801-7. Epub 2007 Mar 6.
Dissection of CDK4-binding and transactivation activities of p34(SEI-1) and comparison between functions of p34(SEI-1) and p16(INK4A).
Li J, Muscarella P, Joo SH, Knobloch TJ, Melvin WS, Weghorst CM, Tsai MD.
Biochemistry. 2005 Oct 11;44(40):13246-56.
Potent activity of a novel dimeric heat shock protein 90 inhibitor against head and neck squamous cell carcinoma in vitro and in vivo.
Yin X, Zhang H, Burrows F, Zhang L, Shores CG.
Clin Cancer Res. 2005 May 15;11(10):3889-96.
p16INK4A positivity in benign, premalignant and malignant cervical glandular lesions: a potential diagnostic problem.
Murphy N, Heffron CC, King B, Ganuguapati UG, Ring M, McGuinness E, Sheils O, O'Leary JJ.
Virchows Arch. 2004 Dec;445(6):610-5. Epub 2004 Sep 18.
Differential alterations of the genes in the CDKN2A-CCND1-CDK4-RB1 pathway are associated with the development of head and neck squamous cell carcinoma in Indian patients.
Tripathi Bhar A, Banerjee S, Chunder N, Roy A, Sengupta A, Roy B, Roychowdhury S, Panda CK.
J Cancer Res Clin Oncol. 2003 Nov;129(11):642-50. Epub 2003 Sep 3.
[Immunohistochemical determination of cell cycle regulatory proteins. No prognostic significance in advanced squamous epithelial carcinomas of the head-neck area].
Kunz C, Bosch FX, Klein-Kühne W, Nollert J, Rudat V, Conradt C, Dietz A.
HNO. 2003 Oct;51(10):800-5. Epub 2003 Apr 9. German.
[Opportunities and chances for tissue chip microarrays in head and neck surgery. A novel technique for the rapid evaluation of potentially novel biomarkers].
Hofele C, Joos S, Flechtenmacher C, Bosch FX, Lichter P, Mühling J, Freier K.
Mund Kiefer Gesichtschir. 2002 Nov;6(6):394-401. Epub 2002 Jul 2. German.
Antitumor activity of UCN-01 in carcinomas of the head and neck is associated with altered expression of cyclin D3 and p27(KIP1).
Patel V, Lahusen T, Leethanakul C, Igishi T, Kremer M, Quintanilla-Martinez L, Ensley JF, Sausville EA, Gutkind JS, Senderowicz AM.
Clin Cancer Res. 2002 Nov;8(11):3549-60.
Cyclin D1 amplification and p16(MTS1/CDK4I) deletion correlate with poor prognosis in head and neck tumors.
Namazie A, Alavi S, Olopade OI, Pauletti G, Aghamohammadi N, Aghamohammadi M, Gornbein JA, Calcaterra TC, Slamon DJ, Wang MB, Srivatsan ES.
Laryngoscope. 2002 Mar;112(3):472-81.
Effect of 9-cis-retinoic acid on oral squamous cell carcinoma cell lines.
Hayashi K, Yokozaki H, Naka K, Yasui W, Yajin K, Lotan R, Tahara E.
Cancer Lett. 2000 Apr 14;151(2):199-208.
[Prognostic significance of cell-cycle regulatory proteins for outcome after primary radiochemotherapy in patients with advanced head and neck cancer].
Haas S, Bosch FX, Klein-Kühne W, Nollert J, Rudat V, Conradt C, Dietz A.
HNO. 1999 Sep;47(9):777-86. German.
Involvement of cyclin D1-cdk5 overexpression and MCM3 cleavage in bax-associated spontaneous apoptosis and differentiation in an A253 human head and neck carcinoma xenograft model.
Yin MB, Tóth K, Cao S, Guo B, Frank C, Slocum HK, Rustum YM.
Int J Cancer. 1999 Oct 29;83(3):341-8.
Cyclin D1 amplification is independent of p16 inactivation in head and neck squamous cell carcinoma.
Okami K, Reed AL, Cairns P, Koch WM, Westra WH, Wehage S, Jen J, Sidransky D.
Oncogene. 1999 Jun 10;18(23):3541-5.
Cyclin E-cdk2 activation is associated with cell cycle arrest and inhibition of DNA replication induced by the thymidylate synthase inhibitor Tomudex.
Yin MB, Guo B, Panadero A, Frank C, Wrzosek C, Slocum HK, Rustum YM.
Exp Cell Res. 1999 Feb 25;247(1):189-99.
Deletion of P15 (MTS2) in head and neck squamous cell carcinomas.
Roesler JM, Livingston EH, Srivatsan E, Chang P, Wang MB.
J Surg Res. 1998 Jun;77(1):50-4.
Cellular factors may enable squamous carcinoma cells to overcome TGF beta-mediated repression of CDK2 activity.
Lesaca EE, Ensley JF, Yeudall WA.
Oral Oncol. 1998 Jan;34(1):52-7.
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