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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1976 1
1977 3
1978 2
1979 10
1980 4
1981 4
1982 36
1983 48
1984 47
1985 40
1986 64
1987 51
1988 46
1989 35
1990 36
1991 24
1992 24
1993 24
1994 21
1995 23
1996 17
1997 12
1998 13
1999 8
2000 16
2001 6
2002 9
2003 7
2004 10
2005 9
2006 12
2007 11
2008 17
2009 17
2010 25
2011 29
2012 32
2013 26
2014 39
2015 48
2016 52
2017 57
2018 40
2019 78
2020 100
2021 81
2022 75
2023 64
2024 28

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1,391 results

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Page 1
Auranofin attenuates hepatic steatosis and fibrosis in nonalcoholic fatty liver disease via NRF2 and NF- kappaB signaling pathways.
Lee SM, Koh DH, Jun DW, Roh YJ, Kang HT, Oh JH, Kim HS. Lee SM, et al. Clin Mol Hepatol. 2022 Oct;28(4):827-840. doi: 10.3350/cmh.2022.0068. Epub 2022 Jun 22. Clin Mol Hepatol. 2022. PMID: 35730208 Free PMC article.
Auranofin reduced liver fibrosis and lipid accumulation in NASH model mice fed on a Western diet. CONCLUSION: Auranofin inhibits lipogenesis and fibrosis formation and is a proposed candidate for NASH treatment....
Auranofin reduced liver fibrosis and lipid accumulation in NASH model mice fed on a Western diet. CONCLUSION: Auranofin inhibi …
Auranofin targets UBA1 and enhances UBA1 activity by facilitating ubiquitin trans-thioesterification to E2 ubiquitin-conjugating enzymes.
Yan W, Zhong Y, Hu X, Xu T, Zhang Y, Kales S, Qu Y, Talley DC, Baljinnyam B, LeClair CA, Simeonov A, Polster BM, Huang R, Ye Y, Rai G, Henderson MJ, Tao D, Fang S. Yan W, et al. Nat Commun. 2023 Aug 9;14(1):4798. doi: 10.1038/s41467-023-40537-x. Nat Commun. 2023. PMID: 37558718 Free PMC article.
Auranofin binds to the UBA1's ubiquitin fold domain and conjugates to Cys1039 residue. ...It also facilitates outer mitochondrial membrane-associated degradation. These findings suggest that auranofin can serve as a much-needed tool for UBA1 research and therapeutic …
Auranofin binds to the UBA1's ubiquitin fold domain and conjugates to Cys1039 residue. ...It also facilitates outer mitochondrial mem …
Gold Preparations.
[No authors listed] [No authors listed] 2017 Aug 2. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. 2017 Aug 2. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. PMID: 31644093 Free Books & Documents. Review.
Gold salts, including auranofin and gold sodium thiomalate, have been used for the therapy of rheumatoid arthritis for many decades, but have recently been replaced by more modern disease-modifying antirheumatic drugs. Parenteral gold therapy (chrysotherapy) can cause acut …
Gold salts, including auranofin and gold sodium thiomalate, have been used for the therapy of rheumatoid arthritis for many decades, …
Auranofin.
Kean WF, Hart L, Buchanan WW. Kean WF, et al. Br J Rheumatol. 1997 May;36(5):560-72. doi: 10.1093/rheumatology/36.5.560. Br J Rheumatol. 1997. PMID: 9189058 Review. No abstract available.
Potential Anticancer Activity of Auranofin.
Onodera T, Momose I, Kawada M. Onodera T, et al. Chem Pharm Bull (Tokyo). 2019;67(3):186-191. doi: 10.1248/cpb.c18-00767. Chem Pharm Bull (Tokyo). 2019. PMID: 30827998 Free article. Review.
Several potential novel applications of auranofin for treating human disease have been proposed. Auranofin inhibits the activity of thioredoxin reductase (TrxR), an enzyme of the thioredoxin (Trx) system that is important for maintaining the intracellular redox stat …
Several potential novel applications of auranofin for treating human disease have been proposed. Auranofin inhibits the activi …
The rheumatoid arthritis drug auranofin lowers leptin levels and exerts antidiabetic effects in obese mice.
Cox AR, Masschelin PM, Saha PK, Felix JB, Sharp R, Lian Z, Xia Y, Chernis N, Bader DA, Kim KH, Li X, Yoshino J, Li X, Li G, Sun Z, Wu H, Coarfa C, Moore DD, Klein S, Sun K, Hartig SM. Cox AR, et al. Cell Metab. 2022 Dec 6;34(12):1932-1946.e7. doi: 10.1016/j.cmet.2022.09.019. Epub 2022 Oct 14. Cell Metab. 2022. PMID: 36243005 Free PMC article.
We also discovered that auranofin accumulation in WAT depleted inflammatory responses to a high-fat diet without altering body composition in obese wild-type mice. Surprisingly, elevated leptin levels and blunted beta-adrenergic receptor activity achieved by leptin recepto …
We also discovered that auranofin accumulation in WAT depleted inflammatory responses to a high-fat diet without altering body compos …
Will Auranofin Become a Golden New Treatment Against COVID-19?
Sonzogni-Desautels K, Ndao M. Sonzogni-Desautels K, et al. Front Immunol. 2021 Sep 22;12:683694. doi: 10.3389/fimmu.2021.683694. eCollection 2021. Front Immunol. 2021. PMID: 34630379 Free PMC article. Review.
Auranofin also possesses antiviral properties. Recently, it was reported that auranofin reduced by 95% SARS-CoV-2 RNA in infected human cells in vitro and decreased SARS-CoV-2-induced cytokine expression, including IL-6. ...In our opinion, auranofin has the p …
Auranofin also possesses antiviral properties. Recently, it was reported that auranofin reduced by 95% SARS-CoV-2 RNA in infec …
[Potential Anticancer Activity of Auranofin].
Momose I, Onodera T, Kawada M. Momose I, et al. Yakugaku Zasshi. 2021;141(3):315-321. doi: 10.1248/yakushi.20-00179-2. Yakugaku Zasshi. 2021. PMID: 33642497 Free article. Review. Japanese.
Furthermore, auranofin demonstrates promising results for the treatment of various diseases beyond rheumatoid arthritis, including cancer, neurodegenerative diseases, acquired immune deficiency syndrome, and bacterial and parasitic infections. Various potential novel appli …
Furthermore, auranofin demonstrates promising results for the treatment of various diseases beyond rheumatoid arthritis, including ca …
Gold Nanoclusters as Nanoantibiotic Auranofin Analogues.
Ndugire W, Raviranga NGH, Lao J, Ramström O, Yan M. Ndugire W, et al. Adv Healthc Mater. 2022 May;11(9):e2101032. doi: 10.1002/adhm.202101032. Epub 2021 Aug 5. Adv Healthc Mater. 2022. PMID: 34350709 Free PMC article.
Herein, the design and synthesis of gold nanoclusters (AuNCs) based on the structural motif of auranofin are reported. Phosphine-capped AuNCs are synthesized and glycosylated, yielding auranofin analogues with mixed triphenylphosphine monosulfonate (TPPMS)/Ac(4) Glc …
Herein, the design and synthesis of gold nanoclusters (AuNCs) based on the structural motif of auranofin are reported. Phosphine-capp …
Auranofin.
Davis P. Davis P. Clin Rheum Dis. 1984 Aug;10(2):369-83. Clin Rheum Dis. 1984. PMID: 6239742 Review.
In addition, the reasons for withdrawal have often been less potentially serious side effects, notably nephrotoxicity and haematological reactions. In a review of over 3000 patients treated with auranofin, compared to 465 patients treated with injectable gold, the frequenc …
In addition, the reasons for withdrawal have often been less potentially serious side effects, notably nephrotoxicity and haematological rea …
1,391 results