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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2000 1
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2004 8
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2007 5
2008 5
2009 5
2010 3
2011 3
2012 4
2013 4
2014 6
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79 results

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Page 1
Management of acute promyelocytic leukemia: updated recommendations from an expert panel of the European LeukemiaNet.
Sanz MA, Fenaux P, Tallman MS, Estey EH, Löwenberg B, Naoe T, Lengfelder E, Döhner H, Burnett AK, Chen SJ, Mathews V, Iland H, Rego E, Kantarjian H, Adès L, Avvisati G, Montesinos P, Platzbecker U, Ravandi F, Russell NH, Lo-Coco F. Sanz MA, et al. Blood. 2019 Apr 11;133(15):1630-1643. doi: 10.1182/blood-2019-01-894980. Epub 2019 Feb 25. Blood. 2019. PMID: 30803991 Free PMC article. Review.
Since the comprehensive recommendations for the management of acute promyelocytic leukemia (APL) reported in 2009, several studies have provided important insights, particularly regarding the role of arsenic trioxide (ATO) in frontline therapy. Ten years later, a Eu …
Since the comprehensive recommendations for the management of acute promyelocytic leukemia (APL) reported in 2009, several studies have prov …
Chemotherapy-Induced Arrhythmias.
Essa H, Dobson R, Lip GYH. Essa H, et al. J Cardiovasc Pharmacol. 2022 Oct 1;80(4):531-539. doi: 10.1097/FJC.0000000000001216. J Cardiovasc Pharmacol. 2022. PMID: 34983915 Review.
Furthermore, various drug interactions can limit the choice of therapy, particularly with respect to anticoagulant drugs. Many chemotherapeutic agents have been implicated in QT interval (A Measurement calculated from the start of the Q wave to the end of the T wave on the …
Furthermore, various drug interactions can limit the choice of therapy, particularly with respect to anticoagulant drugs. Many chemotherapeu …
Arsenic trioxide: safety issues and their management.
Au WY, Kwong YL. Au WY, et al. Acta Pharmacol Sin. 2008 Mar;29(3):296-304. doi: 10.1111/j.1745-7254.2008.00771.x. Acta Pharmacol Sin. 2008. PMID: 18298894 Review.
Arsenic trioxide (As2O3) has been used medicinally for thousands of years. ...Because of slow intestinal absorption, oral-As2O3 gives a lower plasma arsenic concentration, which is associated with lesser QT prolongation and hence a more favorable cardi …
Arsenic trioxide (As2O3) has been used medicinally for thousands of years. ...Because of slow intestinal absorption, oral-As2O …
Oral arsenic trioxide ORH-2014 pharmacokinetic and safety profile in patients with advanced hematologic disorders.
Ravandi F, Koumenis I, Johri A, Tallman M, Roboz GJ, Strickland S, Garcia-Manero G, Borthakur G, Naqvi K, Meyer M, Pudipeddi M, Nidarmarthy S, Vaddi K, Kantarjian H. Ravandi F, et al. Haematologica. 2020 Jun;105(6):1567-1574. doi: 10.3324/haematol.2019.229583. Epub 2019 Sep 26. Haematologica. 2020. PMID: 31558670 Free PMC article.
Daily intravenous arsenic trioxide administered with all-trans retinoid acid, the standard-of-care for acute promyelocytic leukemia, is costly and challenging to administer. ORH-2014 is a novel, oral arsenic trioxide formulation, consisting of micron-s …
Daily intravenous arsenic trioxide administered with all-trans retinoid acid, the standard-of-care for acute promyelocytic leu …
Arsenic cardiotoxicity: An overview.
Alamolhodaei NS, Shirani K, Karimi G. Alamolhodaei NS, et al. Environ Toxicol Pharmacol. 2015 Nov;40(3):1005-14. doi: 10.1016/j.etap.2015.08.030. Epub 2015 Sep 3. Environ Toxicol Pharmacol. 2015. PMID: 26606645 Review.
Several evidences have shown that mitochondrial disruption, caspase activation, MAPK signaling and p53 are the pathways for arsenic induced apoptosis. Arsenic trioxide is an effective and potent antitumor agent used in patients with acute promyelocytic leukem …
Several evidences have shown that mitochondrial disruption, caspase activation, MAPK signaling and p53 are the pathways for arsenic i …
Aloin protects against arsenic trioxide-induced myocardial membrane damage and release of inflammatory cytokines.
Birari LA, Mahajan UB, Patil KR, Patil DD, Bagul NA, Belemkar S, Goyal SN, Ojha S, Patil CR. Birari LA, et al. Naunyn Schmiedebergs Arch Pharmacol. 2020 Aug;393(8):1365-1372. doi: 10.1007/s00210-020-01833-1. Epub 2020 Feb 6. Naunyn Schmiedebergs Arch Pharmacol. 2020. PMID: 32025748
We evaluated the effects of aloin at doses ranging between 1 and 125 mg/kg against the arsenic trioxide (As(2)O(3))-induced cardiotoxicity in mice. As(2)O(3) (5 mg/kg/day) was intraperitoneally administrated for 10 days. Aloin was administered through oral gavage at …
We evaluated the effects of aloin at doses ranging between 1 and 125 mg/kg against the arsenic trioxide (As(2)O(3))-induced ca …
Resveratrol and arsenic trioxide act synergistically to kill tumor cells in vitro and in vivo.
Zhao XY, Yang S, Chen YR, Li PC, Dou MM, Zhang J. Zhao XY, et al. PLoS One. 2014 Jun 5;9(6):e98925. doi: 10.1371/journal.pone.0098925. eCollection 2014. PLoS One. 2014. PMID: 24901647 Free PMC article.
BACKGROUND AND AIMS: Arsenic trioxide (As2O3), which used as an effective agent in the treatment of leukaemia and other solid tumors, is largely limited by its toxicity. QT prolongation, torsades de pointes and sudden heart death have been implicated i …
BACKGROUND AND AIMS: Arsenic trioxide (As2O3), which used as an effective agent in the treatment of leukaemia and other solid …
Resveratrol protects against arsenic trioxide-induced cardiotoxicity in vitro and in vivo.
Zhao XY, Li GY, Liu Y, Chai LM, Chen JX, Zhang Y, Du ZM, Lu YJ, Yang BF. Zhao XY, et al. Br J Pharmacol. 2008 May;154(1):105-13. doi: 10.1038/bjp.2008.81. Epub 2008 Mar 10. Br J Pharmacol. 2008. PMID: 18332854 Free PMC article.
BACKGROUND AND PURPOSE: The clinical use of arsenic trioxide (As(2)O(3)), a potent antineoplastic agent, is limited by its severe cardiotoxic effects. QT interval prolongation and apoptosis have been implicated in the cardiotoxicity of As(2)O(3). ...
BACKGROUND AND PURPOSE: The clinical use of arsenic trioxide (As(2)O(3)), a potent antineoplastic agent, is limited by its sev …
Effect of arsenic trioxide on QT interval in patients with advanced malignancies.
Barbey JT, Pezzullo JC, Soignet SL. Barbey JT, et al. J Clin Oncol. 2003 Oct 1;21(19):3609-15. doi: 10.1200/JCO.2003.10.009. J Clin Oncol. 2003. PMID: 14512391
Since arsenic can prolong the QT interval and lead to torsade de pointes, a life-threatening ventricular arrhythmia, this retrospective analysis was conducted to determine the degree of QT prolongation in patients treated with arsenic trioxid …
Since arsenic can prolong the QT interval and lead to torsade de pointes, a life-threatening ventricular arrhythmia, th …
Arsenic trioxide and angiotensin II have inhibitory effects on HERG protein expression: Evidence for the role of PML SUMOylation.
Liu Y, Li D, Nie D, Liu SK, Qiu F, Liu MT, Li YY, Wang JX, Liu YX, Dong CJ, Wu D, Tian W, Yang J, Mu W, Li JT, Zhao D, Wang XF, Chu WF, Yang BF. Liu Y, et al. Oncotarget. 2017 Jul 11;8(28):45447-45458. doi: 10.18632/oncotarget.17563. Oncotarget. 2017. PMID: 28525371 Free PMC article.
The human ether-a-go-go-related gene (HERG) channel is a novel target for the treatment of drug-induced long QT syndrome, which causes lethal cardiotoxicity. This study is designed to explore the possible role of PML SUMOylation and its associated nuclear bodies (NBs) in t …
The human ether-a-go-go-related gene (HERG) channel is a novel target for the treatment of drug-induced long QT syndrome, which cause …
79 results