Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1950 1
1952 2
1953 1
1958 1
1963 6
1964 3
1965 5
1966 9
1967 16
1968 14
1969 24
1970 28
1971 29
1972 18
1973 27
1974 15
1975 26
1976 25
1977 29
1978 16
1979 14
1980 13
1981 24
1982 20
1983 17
1984 14
1985 7
1986 10
1987 20
1988 11
1989 15
1990 15
1991 19
1992 14
1993 21
1994 22
1995 34
1996 42
1997 36
1998 49
1999 55
2000 68
2001 68
2002 78
2003 102
2004 130
2005 135
2006 176
2007 163
2008 159
2009 191
2010 207
2011 237
2012 253
2013 301
2014 283
2015 298
2016 283
2017 304
2018 333
2019 331
2020 345
2021 337
2022 284
2023 254
2024 112

Text availability

Article attribute

Article type

Publication date

Search Results

5,597 results

Results by year

Filters applied: . Clear all
Page 1
Meta-analysis of human and mouse ALS astrocytes reveals multi-omic signatures of inflammatory reactive states.
Ziff OJ, Clarke BE, Taha DM, Crerar H, Luscombe NM, Patani R. Ziff OJ, et al. Genome Res. 2022 Jan;32(1):71-84. doi: 10.1101/gr.275939.121. Epub 2021 Dec 28. Genome Res. 2022. PMID: 34963663 Free PMC article.
We complemented this by examining other ALS mutations and models using a systematic meta-analysis of all publicly-available ALS astrocyte sequencing data, which included hiPSC-derived astrocytes carrying SOD1, C9orf72, and FUS gene mutations as well as mouse …
We complemented this by examining other ALS mutations and models using a systematic meta-analysis of all publicly-available ALS …
TDP-43 aggregation induced by oxidative stress causes global mitochondrial imbalance in ALS.
Zuo X, Zhou J, Li Y, Wu K, Chen Z, Luo Z, Zhang X, Liang Y, Esteban MA, Zhou Y, Fu XD. Zuo X, et al. Nat Struct Mol Biol. 2021 Feb;28(2):132-142. doi: 10.1038/s41594-020-00537-7. Epub 2021 Jan 4. Nat Struct Mol Biol. 2021. PMID: 33398173
Amyotrophic lateral sclerosis (ALS) was initially thought to be associated with oxidative stress when it was first linked to mutant superoxide dismutase 1 (SOD1). ...Both familial and sporadic ALS are characterized by the aggregation of the essential DNA- and RNA-bi …
Amyotrophic lateral sclerosis (ALS) was initially thought to be associated with oxidative stress when it was first linked to mutant s …
Impaired motor unit recovery and maintenance in a knock-in mouse model of ALS-associated Kif5a variant.
Rich KA, Pino MG, Yalvac ME, Fox A, Harris H, Balch MHH, Arnold WD, Kolb SJ. Rich KA, et al. Neurobiol Dis. 2023 Jun 15;182:106148. doi: 10.1016/j.nbd.2023.106148. Epub 2023 May 8. Neurobiol Dis. 2023. PMID: 37164288 Free PMC article.
To study the molecular and cellular consequences of ALS-associated variants in vivo, we introduced the murine homolog of an ALS-associated KIF5A variant into C57BL/6 mice using CRISPR-Cas9 gene editing which produced mutant Kif5a mRNA and protein in neuronal …
To study the molecular and cellular consequences of ALS-associated variants in vivo, we introduced the murine homolog of an ALS …
Mutant mouse models of ALS.
Messer A. Messer A. Neurobiol Aging. 1994 Mar-Apr;15(2):247-8. doi: 10.1016/0197-4580(94)90123-6. Neurobiol Aging. 1994. PMID: 7838302 Review. No abstract available.
Aberrant DNA and RNA Methylation Occur in Spinal Cord and Skeletal Muscle of Human SOD1 Mouse Models of ALS and in Human ALS: Targeting DNA Methylation Is Therapeutic.
Martin LJ, Adams DA, Niedzwiecki MV, Wong M. Martin LJ, et al. Cells. 2022 Oct 31;11(21):3448. doi: 10.3390/cells11213448. Cells. 2022. PMID: 36359844 Free PMC article.
We hypothesized that epigenetic anomalies in DNA and RNA occur in ALS and examined this idea in: (1) mouse models of ALS, (2) human ALS, and (3) mouse ALS with therapeutic targeting of DNA methylation. ...Genome-wide promoter CpG DNA meth …
We hypothesized that epigenetic anomalies in DNA and RNA occur in ALS and examined this idea in: (1) mouse models of ALS …
Sublethal enteroviral infection exacerbates disease progression in an ALS mouse model.
Xue YC, Liu H, Mohamud Y, Bahreyni A, Zhang J, Cashman NR, Luo H. Xue YC, et al. J Neuroinflammation. 2022 Jan 12;19(1):16. doi: 10.1186/s12974-022-02380-7. J Neuroinflammation. 2022. PMID: 35022041 Free PMC article.
METHODS: Wild-type C57BL/6J and G85R mutant superoxide dismutase 1 (SOD1(G85R)) ALS mice were intracerebroventricularly infected with a sublethal dose of CVB3 or sham-infected. ...RESULTS: We found that sublethal infection (mimicking chronic infection) of SOD1(G85R) …
METHODS: Wild-type C57BL/6J and G85R mutant superoxide dismutase 1 (SOD1(G85R)) ALS mice were intracerebroventricularly infect …
Antisense oligonucleotide silencing of FUS expression as a therapeutic approach in amyotrophic lateral sclerosis.
Korobeynikov VA, Lyashchenko AK, Blanco-Redondo B, Jafar-Nejad P, Shneider NA. Korobeynikov VA, et al. Nat Med. 2022 Jan;28(1):104-116. doi: 10.1038/s41591-021-01615-z. Epub 2022 Jan 24. Nat Med. 2022. PMID: 35075293 Free PMC article.
Fused in sarcoma (FUS) is an RNA-binding protein that is genetically and pathologically associated with rare and aggressive forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). To explore the mechanisms by which mutant FUS causes neurodegeneratio …
Fused in sarcoma (FUS) is an RNA-binding protein that is genetically and pathologically associated with rare and aggressive forms of amyotro …
Ultrasound-enhanced brain delivery of edaravone provides additive amelioration on disease progression in an ALS mouse model.
Shen Y, Zhang J, Xu Y, Sun S, Chen K, Chen S, Yang X, Chen X. Shen Y, et al. Brain Stimul. 2023 Mar-Apr;16(2):628-641. doi: 10.1016/j.brs.2023.03.006. Epub 2023 Mar 16. Brain Stimul. 2023. PMID: 36931463 Free article.
OBJECTIVE: To investigate the effect of FUS/MB-enhanced delivery of therapeutics to the motor cortex on the disease progression by using a transgenic mouse model of ALS. METHODS: Multiple FUS/MB-enhanced deliveries of Edaravone (Eda) to the motor cortex were perform …
OBJECTIVE: To investigate the effect of FUS/MB-enhanced delivery of therapeutics to the motor cortex on the disease progression by using a t …
Integrated analysis of transcriptomic and proteomic alterations in mouse models of ALS/FTD identify early metabolic adaptions with similarities to mitochondrial dysfunction disorders.
Matveeva A, Watters O, Rukhadze A, Khemka N, Gentile D, Perez IF, Llorente-Folch I, Farrell C, Lo Cacciato E, Jackson J, Piazzesi A, Wischhof L, Woods I, Halang L, Hogg M, Muñoz AG, Dillon ET, Matallanas D, Arijs I, Lambrechts D, Bano D, Connolly NMC, Prehn JHM. Matveeva A, et al. Amyotroph Lateral Scler Frontotemporal Degener. 2024 Feb;25(1-2):135-149. doi: 10.1080/21678421.2023.2261979. Epub 2024 Jan 23. Amyotroph Lateral Scler Frontotemporal Degener. 2024. PMID: 37779364
Apart from the accumulation of proteinaceous deposits, emerging literature indicates that aberrant mitochondrial bioenergetics may contribute to the onset and progression of ALS/FTD. Here we sought to investigate the pathophysiological signatures of mitochondrial dysfuncti …
Apart from the accumulation of proteinaceous deposits, emerging literature indicates that aberrant mitochondrial bioenergetics may contribut …
5,597 results

Searches related to "als mouse"