There is currently no consensus in the literature on whether the magnitude of the ground reaction force or loading rate decreases or increases with muscle fatigue. In this article, the effects of lower extremity muscle fatigue on the magnitude of the ground reaction force and loading rate during running and drop landing are examined. Through a systematic search of the literature, 24 articles are identified that satisfy the inclusion criteria and study the relationship between fatigue and the ground reaction force variables during running, single-leg drop landing, and bilateral drop landing. The articles are categorized based on the type of locomotion they study. To determine whether or not the ground reaction force peaks/loading rate are markedly affected by fatigue, meta-analyses are conducted both separately for each type of locomotion and for an aggregate of all studies. The results of the meta-analyses show that the ground reaction force active peak significantly decreases for the following study groups: aggregate of all included studies, studies of drop landing (both single-leg and bilateral), and studies of bilateral landing only. The ground reaction force active peak did not significantly change in running and single-leg drop landing. The effects of muscle fatigue on the magnitude of the ground reaction force impact peak and loading rate was always insignificant.