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Autophagy induction promoted by m(6)A reader YTHDF3 through translation upregulation of FOXO3 mRNA.
Hao W, Dian M, Zhou Y, Zhong Q, Pang W, Li Z, Zhao Y, Ma J, Lin X, Luo R, Li Y, Jia J, Shen H, Huang S, Dai G, Wang J, Sun Y, Xiao D. Hao W, et al. Nat Commun. 2022 Oct 4;13(1):5845. doi: 10.1038/s41467-022-32963-0. Nat Commun. 2022. PMID: 36195598 Free PMC article.
METTL3 depletion leads to a loss of functional m(6)A modification and inhibits YTHDF3-mediated autophagy flux. YTHDF3 promotes autophagy by recognizing m(6)A modification sites around the stop codon of FOXO3 mRNA. YTHDF3 also recruits eIF3a and eIF4B to facil …
METTL3 depletion leads to a loss of functional m(6)A modification and inhibits YTHDF3-mediated autophagy flux. YTHDF3 promotes …
YTHDF3 Induces the Translation of m(6)A-Enriched Gene Transcripts to Promote Breast Cancer Brain Metastasis.
Chang G, Shi L, Ye Y, Shi H, Zeng L, Tiwary S, Huse JT, Huo L, Ma L, Ma Y, Zhang S, Zhu J, Xie V, Li P, Han L, He C, Huang S. Chang G, et al. Cancer Cell. 2020 Dec 14;38(6):857-871.e7. doi: 10.1016/j.ccell.2020.10.004. Epub 2020 Oct 29. Cancer Cell. 2020. PMID: 33125861 Free PMC article.
In addition, little is known regarding the role of m(6)A reader YTHDF3 in human diseases. Here, we show that YTHDF3 overexpression clinically correlates with brain metastases in breast cancer patients. ...Furthermore, overexpression of YTHDF3 in brain metasta …
In addition, little is known regarding the role of m(6)A reader YTHDF3 in human diseases. Here, we show that YTHDF3 overexpres …
YTHDF3 facilitates translation and decay of N(6)-methyladenosine-modified RNA.
Shi H, Wang X, Lu Z, Zhao BS, Ma H, Hsu PJ, Liu C, He C. Shi H, et al. Cell Res. 2017 Mar;27(3):315-328. doi: 10.1038/cr.2017.15. Epub 2017 Jan 20. Cell Res. 2017. PMID: 28106072 Free PMC article.
Here, we report that YTHDF3 promotes protein synthesis in synergy with YTHDF1, and affects methylated mRNA decay mediated through YTHDF2. ...These results indicate that together with YTHDF1 and YTHDF2, YTHDF3 plays critical roles to accelerate metabolism of m(6)A-mo …
Here, we report that YTHDF3 promotes protein synthesis in synergy with YTHDF1, and affects methylated mRNA decay mediated through YTH …
Long noncoding RNA GAS5 inhibits progression of colorectal cancer by interacting with and triggering YAP phosphorylation and degradation and is negatively regulated by the m(6)A reader YTHDF3.
Ni W, Yao S, Zhou Y, Liu Y, Huang P, Zhou A, Liu J, Che L, Li J. Ni W, et al. Mol Cancer. 2019 Oct 16;18(1):143. doi: 10.1186/s12943-019-1079-y. Mol Cancer. 2019. PMID: 31619268 Free PMC article.
MeRIP-sequencing combined with lncRNA-sequencing were used to identify the m(6)A modified targets of YTHDF3 in CRC. Gain-of-function and Loss-of-function analysis were performed to measure the function of GAS5-YAP-YTHDF3 axis in CRC progression in vitro and in vivo. …
MeRIP-sequencing combined with lncRNA-sequencing were used to identify the m(6)A modified targets of YTHDF3 in CRC. Gain-of-function …
The m6A reader YTHDF3-mediated PRDX3 translation alleviates liver fibrosis.
Sun R, Tian X, Li Y, Zhao Y, Wang Z, Hu Y, Zhang L, Wang Y, Gao D, Zheng S, Yao J. Sun R, et al. Redox Biol. 2022 Aug;54:102378. doi: 10.1016/j.redox.2022.102378. Epub 2022 Jun 24. Redox Biol. 2022. PMID: 35779442 Free PMC article.
Furthermore, PRDX3 mRNA was modified by m6A and interacted with the m6A readers YTH domain family proteins 1-3 (YTHDF1-3), as evidenced by RNA pull-down/mass spectrometry. More importantly, PRDX3 expression was suppressed when YTHDF3, but not YTHDF1/2, was knocked down. Mo …
Furthermore, PRDX3 mRNA was modified by m6A and interacted with the m6A readers YTH domain family proteins 1-3 (YTHDF1-3), as evidenced by R …
N6-methyladenosine reader YTHDF3 regulates melanoma metastasis via its 'executor'LOXL3.
Shi HZ, Xiong JS, Gan L, Zhang Y, Zhang CC, Kong YQ, Miao QJ, Tian CC, Li R, Liu JQ, Zhang EJ, Bu WB, Wang Y, Cheng XF, Sun JF, Chen H. Shi HZ, et al. Clin Transl Med. 2022 Nov;12(11):e1075. doi: 10.1002/ctm2.1075. Clin Transl Med. 2022. PMID: 36324258 Free PMC article.
RESULTS: In this study, we found that m6A reader YTHDF3 could affect the metastasis of melanoma both in vitro and in vivo. ...Besides, RT-qPCR, Western blot, RIP-qPCR and MeRIP-qPCR were performed for subsequent validation. Among various targets of YTHDF3, LOXL3 was …
RESULTS: In this study, we found that m6A reader YTHDF3 could affect the metastasis of melanoma both in vitro and in vivo. ...Besides …
m(6)A reader YTHDF3 is associated with clinical prognosis, related RNA signatures and immunosuppression in gastric cancer.
Yu Y, Meng LL, Chen XY, Fan HN, Chen M, Zhang J, Zhu JS. Yu Y, et al. Cell Signal. 2023 Aug;108:110699. doi: 10.1016/j.cellsig.2023.110699. Epub 2023 May 5. Cell Signal. 2023. PMID: 37149073
BACKGROUND: YTHDF3 as a N6-methyladenosine (m6A) reader participates in the development and progression of multiple cancer types, however, the prognosis, molecular biology and immune infiltration of YTHDF3 in gastric cancer (GC) have not been investigated. ...The es …
BACKGROUND: YTHDF3 as a N6-methyladenosine (m6A) reader participates in the development and progression of multiple cancer types, how …
YTHDF3 Modulates EGFR/ATK/ERK/p21 Signaling Axis to Promote Cancer Progression and Osimertinib Resistance of Glioblastoma Cells.
Lee HH, Hsieh CC, Chang CC, Liao WT, Chi HC. Lee HH, et al. Anticancer Res. 2023 Dec;43(12):5485-5498. doi: 10.21873/anticanres.16751. Anticancer Res. 2023. PMID: 38030188
Signaling pathways and an in vivo xenograft model of U87(OSR) cells were investigated to delineate the influence of osimertinib-resistance and elevated YTHDF3 expression. RESULTS: YTHDF3 played a crucial role in inducing cellular proliferation, migration, and stemne …
Signaling pathways and an in vivo xenograft model of U87(OSR) cells were investigated to delineate the influence of osimertinib-resistance a …
Epitranscriptomic turbo for autophagy boost: m(6)A reader YTHDF3.
Hao W, Dian M, Wang J, Sun Y, Xiao D. Hao W, et al. Autophagy. 2023 Jun;19(6):1882-1884. doi: 10.1080/15548627.2022.2146890. Epub 2022 Nov 29. Autophagy. 2023. PMID: 36374269 Free PMC article.
However, whether epitranscriptomic events are involved in this process remains unclear. Our recent findings suggest that m(6)A reader YTHDF3 has an essential role in autophagy induction. Elevated m(6)A modifications installed by METTL3 enable YTHDF3 to promote autop …
However, whether epitranscriptomic events are involved in this process remains unclear. Our recent findings suggest that m(6)A reader YTH …
212 results