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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1991 2
1992 2
1993 1
1994 3
1995 3
1996 7
1997 1
1998 3
1999 9
2000 9
2001 6
2002 5
2003 15
2004 10
2005 9
2006 16
2007 27
2008 28
2009 41
2010 48
2011 36
2012 47
2013 44
2014 52
2015 57
2016 78
2017 72
2018 72
2019 84
2020 93
2021 95
2022 140
2023 150
2024 65

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1,166 results

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Page 1
VDAC1, mitochondrial dysfunction, and Alzheimer's disease.
Shoshan-Barmatz V, Nahon-Crystal E, Shteinfer-Kuzmine A, Gupta R. Shoshan-Barmatz V, et al. Pharmacol Res. 2018 May;131:87-101. doi: 10.1016/j.phrs.2018.03.010. Epub 2018 Mar 15. Pharmacol Res. 2018. PMID: 29551631 Review.
The focus of this review is the involvement of mitochondrial dysfunction in AD, and specifically, the role of the voltage-dependent anion channel 1 (VDAC1), which has been linked to AD pathogenesis. VDAC1 is a multi-functional protein, expressed in the mitochondria …
The focus of this review is the involvement of mitochondrial dysfunction in AD, and specifically, the role of the voltage-dependent anion ch …
VDAC1 at the Intersection of Cell Metabolism, Apoptosis, and Diseases.
Shoshan-Barmatz V, Shteinfer-Kuzmine A, Verma A. Shoshan-Barmatz V, et al. Biomolecules. 2020 Oct 26;10(11):1485. doi: 10.3390/biom10111485. Biomolecules. 2020. PMID: 33114780 Free PMC article. Review.
The voltage-dependent anion channel 1 (VDAC1) protein, is an important regulator of mitochondrial function, and serves as a mitochondrial gatekeeper, with responsibility for cellular fate. ...Apoptotic and pathological conditions, as well as certain viruses, induce cell de …
The voltage-dependent anion channel 1 (VDAC1) protein, is an important regulator of mitochondrial function, and serves as a mitochond …
Hypoxia-induced GPCPD1 depalmitoylation triggers mitophagy via regulating PRKN-mediated ubiquitination of VDAC1.
Liu Y, Zhang H, Liu Y, Zhang S, Su P, Wang L, Li Y, Liang Y, Wang X, Zhao W, Chen B, Luo D, Zhang N, Yang Q. Liu Y, et al. Autophagy. 2023 Sep;19(9):2443-2463. doi: 10.1080/15548627.2023.2182482. Epub 2023 Mar 1. Autophagy. 2023. PMID: 36803235 Free PMC article.
Under the hypoxic condition, we found that GPCPD1 was depalmitoylated by LYPLA1, which facilitated the relocating of GPCPD1 to the outer mitochondrial membrane (OMM). Mitochondria-localized GPCPD1 could bind to VDAC1, the substrate for PRKN/PARKIN-dependent ubiquitination, …
Under the hypoxic condition, we found that GPCPD1 was depalmitoylated by LYPLA1, which facilitated the relocating of GPCPD1 to the outer mit …
IP3R1/GRP75/VDAC1 complex mediates endoplasmic reticulum stress-mitochondrial oxidative stress in diabetic atrial remodeling.
Yuan M, Gong M, He J, Xie B, Zhang Z, Meng L, Tse G, Zhao Y, Bao Q, Zhang Y, Yuan M, Liu X, Luo C, Wang F, Li G, Liu T. Yuan M, et al. Redox Biol. 2022 Jun;52:102289. doi: 10.1016/j.redox.2022.102289. Epub 2022 Mar 21. Redox Biol. 2022. PMID: 35344886 Free PMC article.
In situ proximity ligation assay indicated that TM led to increased protein expression of the IP3R1-GRP75-VDAC1 (inositol 1,4,5-trisphosphate receptor 1-glucose-regulated protein 75-voltage-dependent anion channel 1) complex in HL-1 cells. ...Moreover, GRP75 deficiency att …
In situ proximity ligation assay indicated that TM led to increased protein expression of the IP3R1-GRP75-VDAC1 (inositol 1,4,5-trisp …
Decision between mitophagy and apoptosis by Parkin via VDAC1 ubiquitination.
Ham SJ, Lee D, Yoo H, Jun K, Shin H, Chung J. Ham SJ, et al. Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):4281-4291. doi: 10.1073/pnas.1909814117. Epub 2020 Feb 11. Proc Natl Acad Sci U S A. 2020. PMID: 32047033 Free PMC article.
VDAC1 is a critical substrate of Parkin responsible for the regulation of mitophagy and apoptosis. ...VDAC1 deficient with polyubiquitination (VDAC1 Poly-KR) hampers mitophagy, but VDAC1 deficient with monoubiquitination (VDAC1 K274R) promotes a …
VDAC1 is a critical substrate of Parkin responsible for the regulation of mitophagy and apoptosis. ...VDAC1 deficient with pol …
HNF4A-BAP31-VDAC1 axis synchronously regulates cell proliferation and ferroptosis in gastric cancer.
Zhou Q, Liu T, Qian W, Ji J, Cai Q, Jin Y, Jiang J, Zhang J. Zhou Q, et al. Cell Death Dis. 2023 Jun 9;14(6):356. doi: 10.1038/s41419-023-05868-z. Cell Death Dis. 2023. PMID: 37296105 Free PMC article.
Mechanistically, BAP31 regulated cell proliferation and ferroptosis by directly binding to VDAC1 and affected VDAC1 oligomerization and polyubiquitination. ...
Mechanistically, BAP31 regulated cell proliferation and ferroptosis by directly binding to VDAC1 and affected VDAC1 oligomeriz …
Antidepressant drug sertraline modulates AMPK-MTOR signaling-mediated autophagy via targeting mitochondrial VDAC1 protein.
Hwang HY, Shim JS, Kim D, Kwon HJ. Hwang HY, et al. Autophagy. 2021 Oct;17(10):2783-2799. doi: 10.1080/15548627.2020.1841953. Epub 2020 Nov 9. Autophagy. 2021. PMID: 33124469 Free PMC article.
Mechanistically, Sert potentially binds to and antagonizes the mitochondrial VDAC1 (voltage dependent anion channel 1), resulting in reduced cellular ATP (adenosine triphosphate) level, activation of AMP-activated protein kinase (AMPK) and inhibition of its downstream, MTO …
Mechanistically, Sert potentially binds to and antagonizes the mitochondrial VDAC1 (voltage dependent anion channel 1), resulting in …
Site-specific ubiquitination of VDAC1 restricts its oligomerization and mitochondrial DNA release in liver fibrosis.
Wu NN, Wang L, Wang L, Xu X, Lopaschuk GD, Zhang Y, Ren J. Wu NN, et al. Exp Mol Med. 2023 Jan;55(1):269-280. doi: 10.1038/s12276-022-00923-9. Epub 2023 Jan 19. Exp Mol Med. 2023. PMID: 36658227 Free PMC article.
We found that site-specific ubiquitination of VDAC1 at lysine 53 by Parkin interrupted VDAC1 oligomerization and prevented mtDNA release into the cytoplasm under stress. ...We propose that the ubiquitination of VDAC1 at a specific site by Parkin confers prote …
We found that site-specific ubiquitination of VDAC1 at lysine 53 by Parkin interrupted VDAC1 oligomerization and prevented mtD …
Protecting mitochondria via inhibiting VDAC1 oligomerization alleviates ferroptosis in acetaminophen-induced acute liver injury.
Niu B, Lei X, Xu Q, Ju Y, Xu D, Mao L, Li J, Zheng Y, Sun N, Zhang X, Mao Y, Li X. Niu B, et al. Cell Biol Toxicol. 2022 Jun;38(3):505-530. doi: 10.1007/s10565-021-09624-x. Epub 2021 Aug 17. Cell Biol Toxicol. 2022. PMID: 34401974
Mitochondrial dysfunction, which is associated with the tricarboxylic acid cycle and fatty acid beta-oxidation suppression, may drive APAP-induced ferroptosis in hepatocytes. APAP overdose induced VDAC1 oligomerization in hepatocytes, and protecting mitochondria via VBIT-1 …
Mitochondrial dysfunction, which is associated with the tricarboxylic acid cycle and fatty acid beta-oxidation suppression, may drive APAP-i …
TMBIM6 prevents VDAC1 multimerization and improves mitochondrial quality control to reduce sepsis-related myocardial injury.
Zhou H, Dai Z, Li J, Wang J, Zhu H, Chang X, Wang Y. Zhou H, et al. Metabolism. 2023 Mar;140:155383. doi: 10.1016/j.metabol.2022.155383. Epub 2023 Jan 2. Metabolism. 2023. PMID: 36603706
Structural protein analysis, Co-IP, mutant TMBIM6 plasmid transfection, and molecular docking assays subsequently indicated that TMBIM6 exerts cardioprotection against LPS-induced sepsis by interacting with and preventing the oligomerization of voltage-dependent anion channel-1 ( …
Structural protein analysis, Co-IP, mutant TMBIM6 plasmid transfection, and molecular docking assays subsequently indicated that TMBIM6 exer …
1,166 results