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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 1
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2002 1
2003 3
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2005 2
2006 3
2007 5
2008 5
2009 7
2010 5
2011 1
2012 1
2013 2
2014 4
2015 1
2016 4
2017 7
2018 4
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2020 3
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2023 3
2024 0

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72 results

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Page 1
UNC5A, an epigenetically silenced gene, functions as a tumor suppressor in non-small cell lung cancer.
Ding S, Zhang H, Zhao X, Dang J, Li G. Ding S, et al. Saudi J Biol Sci. 2020 Nov;27(11):3009-3017. doi: 10.1016/j.sjbs.2020.09.023. Epub 2020 Sep 17. Saudi J Biol Sci. 2020. PMID: 33100860 Free PMC article.
Functionally, knockdown of UNC5A promoted cell proliferation, migration, invasion and induced apoptosis in NSCLC, overexpression of UNC5A yielded the opposite result. Moreover, we found that UNC5A negatively regulated PI3K/Akt signaling pathway in NSCLC. U …
Functionally, knockdown of UNC5A promoted cell proliferation, migration, invasion and induced apoptosis in NSCLC, overexpression of …
GPC3-Unc5 receptor complex structure and role in cell migration.
Akkermans O, Delloye-Bourgeois C, Peregrina C, Carrasquero-Ordaz M, Kokolaki M, Berbeira-Santana M, Chavent M, Reynaud F, Raj R, Agirre J, Aksu M, White ES, Lowe E, Ben Amar D, Zaballa S, Huo J, Pakos I, McCubbin PTN, Comoletti D, Owens RJ, Robinson CV, Castellani V, Del Toro D, Seiradake E. Akkermans O, et al. Cell. 2022 Oct 13;185(21):3931-3949.e26. doi: 10.1016/j.cell.2022.09.025. Cell. 2022. PMID: 36240740 Free PMC article.
Syntaxin-1 is necessary for UNC5A-C/Netrin-1-dependent macropinocytosis and chemorepulsion.
Martínez-Mármol R, Muhaisen A, Cotrufo T, Roselló-Busquets C, Ros O, Hernaiz-Llorens M, Pérez-Branguli F, Andrés RM, Parcerisas A, Pascual M, Ulloa F, Soriano E. Martínez-Mármol R, et al. Front Mol Neurosci. 2023 Sep 27;16:1253954. doi: 10.3389/fnmol.2023.1253954. eCollection 2023. Front Mol Neurosci. 2023. PMID: 37829513 Free PMC article.
RESULTS AND DISCUSSION: Here, we demonstrate that this response is characterized by enhanced membrane internalization through macropinocytosis, but not clathrin-mediated endocytosis. We show that UNC5A, UNC5B, and UNC5C receptors form a protein complex with the t-SNARE syn …
RESULTS AND DISCUSSION: Here, we demonstrate that this response is characterized by enhanced membrane internalization through macropinocytos …
Dependence receptor UNC5A restricts luminal to basal breast cancer plasticity and metastasis.
Padua MB, Bhat-Nakshatri P, Anjanappa M, Prasad MS, Hao Y, Rao X, Liu S, Wan J, Liu Y, McElyea K, Jacobsen M, Sandusky G, Althouse S, Perkins S, Nakshatri H. Padua MB, et al. Breast Cancer Res. 2018 May 2;20(1):35. doi: 10.1186/s13058-018-0963-5. Breast Cancer Res. 2018. PMID: 29720215 Free PMC article.
Mammosphere assay, flow cytometry, and immunofluorescence were used to determine the role of UNC5A in restricting plasticity. Xenograft models were used to measure the effect of UNC5A knockdown on tumor growth and metastasis. ...Consistent with in vitro results, …
Mammosphere assay, flow cytometry, and immunofluorescence were used to determine the role of UNC5A in restricting plasticity. Xenogra …
FANCC localizes with UNC5A at neurite outgrowth and promotes neuritogenesis.
Huang F, Ben Aissa M, Lévesque G, Carreau M. Huang F, et al. BMC Res Notes. 2018 Sep 12;11(1):662. doi: 10.1186/s13104-018-3763-1. BMC Res Notes. 2018. PMID: 30213274 Free PMC article.
OBJECTIVE: The Uncoordinated 5A (UNC5A) protein is part of a family of receptors that play roles in axonal pathfinding and cell migration. ...Given the direct interaction between FANCC and UNC5A and that FANCC interferes with UNC5A-mediated apoptosis, we expl …
OBJECTIVE: The Uncoordinated 5A (UNC5A) protein is part of a family of receptors that play roles in axonal pathfinding and cell migra …
DNA damage-inducible gene, UNC5A, functions as a tumor-suppressor in bladder cancer.
Zhu Y, Yu M, Chen Y, Wang Y, Wang J, Yang C, Bi J. Zhu Y, et al. Tumour Biol. 2014 Jul;35(7):6887-91. doi: 10.1007/s13277-014-1930-0. Epub 2014 Apr 16. Tumour Biol. 2014. PMID: 24737586
UNC5 receptors are putative tumor suppressors whose expressions are lost in some cancers, but the role of UNC5A during DNA damage in bladder cancer remains undefined. To investigate into the potential function of UNC5A in bladder cancer, we examined UNC5A exp …
UNC5 receptors are putative tumor suppressors whose expressions are lost in some cancers, but the role of UNC5A during DNA damage in …
A Systematic Analysis of the Role of Unc-5 Netrin Receptor A (UNC5A) in Human Cancers.
Zhou Z, Fan B, Cheng H, Wang M, Xie J, Zou M, Yang Y. Zhou Z, et al. Biomolecules. 2022 Dec 6;12(12):1826. doi: 10.3390/biom12121826. Biomolecules. 2022. PMID: 36551254 Free PMC article.
Unc-5 netrin receptor A (UNC5A), a netrin family receptor, plays a key role in neuronal development and subsequent differentiation. ...The mutational landscape of UNC5A exhibited that patients with UNC5A mutations had poorer progress free survival (PFS) in he …
Unc-5 netrin receptor A (UNC5A), a netrin family receptor, plays a key role in neuronal development and subsequent differentiation. . …
The association of UNC5A expression with the clinicopathologic features and prognosis of radiotherapy in patients with non-small-cell lung cancer.
Ding S, Li G, Dang J, Zhao X. Ding S, et al. Int J Clin Exp Pathol. 2018 Aug 1;11(8):3835-3845. eCollection 2018. Int J Clin Exp Pathol. 2018. PMID: 31949771 Free PMC article.
Immunohistochemical staining was evaluated to analyze the expression of UNC5A in NSCLC tissues. The expressions of UNC5A in normal and NSCLC tissues were analyzed using the Oncomine database. ...CONCLUSION: The expression of UNC5A may be a potential prognosti …
Immunohistochemical staining was evaluated to analyze the expression of UNC5A in NSCLC tissues. The expressions of UNC5A in no …
Identification of UNC5A as a novel transcriptional target of tumor suppressor p53 and a regulator of apoptosis.
Miyamoto Y, Futamura M, Kitamura N, Nakamura Y, Baba H, Arakawa H. Miyamoto Y, et al. Int J Oncol. 2010 May;36(5):1253-60. doi: 10.3892/ijo_00000609. Int J Oncol. 2010. PMID: 20372800
Emerging evidence suggests that axon guidance molecules including UNC5A regulate apoptosis in non-neuronal cells. Here, we report that UNC5A regulates apoptosis as a downstream target of p53. UNC5A expression was strongly induced by exogenous and endogenous p …
Emerging evidence suggests that axon guidance molecules including UNC5A regulate apoptosis in non-neuronal cells. Here, we report tha …
UNC5A promotes neuronal apoptosis during spinal cord development independent of netrin-1.
Williams ME, Lu X, McKenna WL, Washington R, Boyette A, Strickland P, Dillon A, Kaprielian Z, Tessier-Lavigne M, Hinck L. Williams ME, et al. Nat Neurosci. 2006 Aug;9(8):996-8. doi: 10.1038/nn1736. Epub 2006 Jul 9. Nat Neurosci. 2006. PMID: 16829956
In addition to their role as chemorepellent netrin-1 receptors, UNC5 proteins may mediate cell death because they induce apoptosis in cultured cells. To test this in vivo, we generated Unc5a (formerly Unc5h1) knockout mice and found that this deletion decreased apoptosis a …
In addition to their role as chemorepellent netrin-1 receptors, UNC5 proteins may mediate cell death because they induce apoptosis in cultur …
72 results