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Year Number of Results
1996 1
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1998 4
1999 3
2000 4
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2002 6
2003 2
2004 4
2005 5
2006 8
2007 12
2008 26
2009 18
2010 17
2011 20
2012 23
2013 32
2014 9
2015 26
2016 25
2017 18
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2020 15
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326 results

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Page 1
UGT2B17 modifies drug response in chronic lymphocytic leukaemia.
Allain EP, Rouleau M, Vanura K, Tremblay S, Vaillancourt J, Bat V, Caron P, Villeneuve L, Labriet A, Turcotte V, Le T, Shehata M, Schnabl S, Demirtas D, Hubmann R, Joly-Beauparlant C, Droit A, Jäger U, Staber PB, Lévesque E, Guillemette C. Allain EP, et al. Br J Cancer. 2020 Jul;123(2):240-251. doi: 10.1038/s41416-020-0887-6. Epub 2020 May 18. Br J Cancer. 2020. PMID: 32418995 Free PMC article.
RESULTS: High UGT2B17 in B-cell models led to reduced sensitivity to fludarabine, ibrutinib and idelalisib. ...The expression changes linked to UGT2B17 exposed nuclear factor kappa B as a key regulatory hub. CONCLUSIONS: Data imply that UGT2B17 represents a m …
RESULTS: High UGT2B17 in B-cell models led to reduced sensitivity to fludarabine, ibrutinib and idelalisib. ...The expression changes …
UGT2B17 Polymorphism and Risk of Prostate Cancer: A Meta-Analysis.
Kpoghomou MA, Soatiana JE, Kalembo FW, Bishwajit G, Sheng W. Kpoghomou MA, et al. ISRN Oncol. 2013 Sep 9;2013:465916. doi: 10.1155/2013/465916. ISRN Oncol. 2013. PMID: 24106614 Free PMC article. Review.
According to our inclusion criteria, studies that observed the association between UGT2B17 polymorphism and PCa risk were included. The principal outcome measure was the adjusted odds ratio (OR) with 95% confidence interval (CI) for the risk of PCa associated with UGT2B …
According to our inclusion criteria, studies that observed the association between UGT2B17 polymorphism and PCa risk were included. T …
Role of the UGT2B17 deletion in exemestane pharmacogenetics.
Luo S, Chen G, Truica C, Baird CC, Leitzel K, Lazarus P. Luo S, et al. Pharmacogenomics J. 2018 Apr;18(2):295-300. doi: 10.1038/tpj.2017.18. Epub 2017 May 23. Pharmacogenomics J. 2018. PMID: 28534527 Free PMC article.
The plasma levels of 17beta-DHE-Gluc was decreased 29-fold (P<0.0001) in subjects with the UGT2B17 (*2/*2) genotype vs subjects with UGT2B17 (*1/*1) genotype. The levels of plasma EXE-adjusted 17beta-DHE was 28% higher (P=0.04) in subjects with the UGT2B17 …
The plasma levels of 17beta-DHE-Gluc was decreased 29-fold (P<0.0001) in subjects with the UGT2B17 (*2/*2) genotype vs subjects wi …
A Non-Canonical Role for the Glycosyltransferase Enzyme UGT2B17 as a Novel Constituent of the B Cell Receptor Signalosome.
Wagner A, Rouleau M, Villeneuve L, Le T, Peltier C, Allain ÉP, Beaudoin C, Tremblay S, Courtier F, Nguyen Van Long F, Laverdière I, Lévesque É, Banerji V, Vanura K, Guillemette C. Wagner A, et al. Cells. 2023 May 2;12(9):1295. doi: 10.3390/cells12091295. Cells. 2023. PMID: 37174695 Free PMC article.
In chronic lymphocytic leukemia (CLL), an elevated glycosyltransferase UGT2B17 expression (UGT2B17(HI)) identifies a subgroup of patients with shorter survival and poor drug response. ...Their combined high expression levels in the treatment of naive patients furthe …
In chronic lymphocytic leukemia (CLL), an elevated glycosyltransferase UGT2B17 expression (UGT2B17(HI)) identifies a subgroup …
Intestinal Metabolism of Diclofenac by Polymorphic UGT2B17 Correlates with its Highly Variable Pharmacokinetics and Safety across Populations.
Ahire D, Heyward S, Prasad B. Ahire D, et al. Clin Pharmacol Ther. 2023 Jul;114(1):161-172. doi: 10.1002/cpt.2907. Epub 2023 Apr 29. Clin Pharmacol Ther. 2023. PMID: 37042794
The human intestinal and liver microsomes isolated from the high-UGT2B17 expressing individuals showed 21- and 4-fold greater rate of diclofenac glucuronide (DG) formation than in the null-UGT2B17 carriers, respectively. The greater contribution of intestinal UGT …
The human intestinal and liver microsomes isolated from the high-UGT2B17 expressing individuals showed 21- and 4-fold greater rate of …
UGT2B17 copy number gain in a large ankylosing spondylitis multiplex family.
Uddin M, Maksymowych WP, Inman R, Gladman D, Munn A, Yazdani R, Pellett F, Hamilton S, O'Rielly DD, Rahman P. Uddin M, et al. BMC Genet. 2013 Aug 8;14:67. doi: 10.1186/1471-2156-14-67. BMC Genet. 2013. PMID: 23927372 Free PMC article.
Based on the proposed function and the polymorphic nature of the UGT2B17 gene, the UGT2B17 gene CNV was selected for validation using real time QF-PCR with full concordance. The frequency of two copies of the UGT2B17 gene CNV was 0.41 in the Newfoundland AS c …
Based on the proposed function and the polymorphic nature of the UGT2B17 gene, the UGT2B17 gene CNV was selected for validatio …
UGT2B17 Expedites Progression of Castration-Resistant Prostate Cancers by Promoting Ligand-Independent AR Signaling.
Li H, Xie N, Chen R, Verreault M, Fazli L, Gleave ME, Barbier O, Dong X. Li H, et al. Cancer Res. 2016 Nov 15;76(22):6701-6711. doi: 10.1158/0008-5472.CAN-16-1518. Epub 2016 Sep 22. Cancer Res. 2016. PMID: 27659047
These UGT2B17 actions were mainly mediated by activation of the c-Src kinase. In CRPC tumors, UGT2B17 expression was associated positively with c-Src activation. ...
These UGT2B17 actions were mainly mediated by activation of the c-Src kinase. In CRPC tumors, UGT2B17 expression was associate …
Multiple roles for UDP-glucuronosyltransferase (UGT)2B15 and UGT2B17 enzymes in androgen metabolism and prostate cancer evolution.
Gauthier-Landry L, Bélanger A, Barbier O. Gauthier-Landry L, et al. J Steroid Biochem Mol Biol. 2015 Jan;145:187-92. doi: 10.1016/j.jsbmb.2014.05.009. Epub 2014 May 23. J Steroid Biochem Mol Biol. 2015. PMID: 24861263 Review.
The formation of these last derivatives through the glucuronidation reaction involves 2 UDP-glucuronosyltransferase (UGT) enzymes, namely UGT2B15 and UGT2B17. The present review article aims at providing a comprehensive view of the physiological and pharmacological importa …
The formation of these last derivatives through the glucuronidation reaction involves 2 UDP-glucuronosyltransferase (UGT) enzymes, namely UG …
UGT2B17 gene deletion associated with an increase in bone mineral density similar to the effect of hormone replacement in postmenopausal women.
Giroux S, Bussières J, Bureau A, Rousseau F. Giroux S, et al. Osteoporos Int. 2012 Mar;23(3):1163-70. doi: 10.1007/s00198-011-1662-6. Epub 2011 May 26. Osteoporos Int. 2012. PMID: 21614655
UGT2B17 is one of the most important enzymes for androgen metabolism. In addition, the UGT2B17 gene is one of the most commonly deleted regions of the human genome. ...
UGT2B17 is one of the most important enzymes for androgen metabolism. In addition, the UGT2B17 gene is one of the most commonl …
Function of UDP-glucuronosyltransferase 2B17 (UGT2B17) is involved in endometrial cancer.
Hirata H, Hinoda Y, Zaman MS, Chen Y, Ueno K, Majid S, Tripsas C, Rubin M, Chen LM, Dahiya R. Hirata H, et al. Carcinogenesis. 2010 Sep;31(9):1620-6. doi: 10.1093/carcin/bgq124. Epub 2010 Jun 16. Carcinogenesis. 2010. PMID: 20554747 Free PMC article.
Therefore, we focused on the function of UGT2B17 in EC. A total of nine patients with confirmed EC were enrolled in this study to investigate the expression of UGT2B17 and target genes. ...We also found upregulation of Puma protein, a target of Mcl-1, in si-UGT2B …
Therefore, we focused on the function of UGT2B17 in EC. A total of nine patients with confirmed EC were enrolled in this study to inv …
326 results