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Simvastatin impairs exercise training adaptations.
Mikus CR, Boyle LJ, Borengasser SJ, Oberlin DJ, Naples SP, Fletcher J, Meers GM, Ruebel M, Laughlin MH, Dellsperger KC, Fadel PJ, Thyfault JP. Mikus CR, et al. J Am Coll Cardiol. 2013 Aug 20;62(8):709-14. doi: 10.1016/j.jacc.2013.02.074. Epub 2013 Apr 10. J Am Coll Cardiol. 2013. PMID: 23583255 Free PMC article. Clinical Trial.

Cardiorespiratory fitness increased by 10% (p < 0.05) in response to exercise training alone, but was blunted by the addition of simvastatin resulting in only a 1.5% increase (p < 0.005 for group by time interaction). Similarly, skeletal muscle citrate synthase activ

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Cardiorespiratory fitness increased by 10% (p < 0.05) in response to exercise training alone, but was blunted by the addition of simva

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The effects of improved metabolic risk factors on bone turnover markers after 12 weeks of simvastatin treatment with or without exercise.
Jiang J, Boyle LJ, Mikus CR, Oberlin DJ, Fletcher JA, Thyfault JP, Hinton PS. Jiang J, et al. Metabolism. 2014 Nov;63(11):1398-408. doi: 10.1016/j.metabol.2014.07.011. Epub 2014 Jul 25. Metabolism. 2014. PMID: 25151031 Clinical Trial.
METHODS: Fifty participants with 2 metabolic syndrome defining characteristics were randomly assigned to one of three groups: statin (STAT: simvastatin, 40 mg/day), exercise (EX: brisk walking and/or slow jogging, 45 minutes/day, 5 days/week), or the combination (STAT+EX). …
METHODS: Fifty participants with 2 metabolic syndrome defining characteristics were randomly assigned to one of three groups: statin (STAT: …