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TUBB4A interacts with MYH9 to protect the nucleus during cell migration and promotes prostate cancer via GSK3beta/beta-catenin signalling.
Gao S, Wang S, Zhao Z, Zhang C, Liu Z, Ye P, Xu Z, Yi B, Jiao K, Naik GA, Wei S, Rais-Bahrami S, Bae S, Yang WH, Sonpavde G, Liu R, Wang L. Gao S, et al. Nat Commun. 2022 May 19;13(1):2792. doi: 10.1038/s41467-022-30409-1. Nat Commun. 2022. PMID: 35589707 Free PMC article.
Human tubulin beta class IVa (TUBB4A) is a member of the beta-tubulin family. In most normal tissues, expression of TUBB4A is little to none, but it is highly expressed in human prostate cancer. ...Our results suggest an oncogenic role of TUBB4A and pr …
Human tubulin beta class IVa (TUBB4A) is a member of the beta-tubulin family. In most normal tissues, expression of TUBB4A is …
Motor protein binding and mitochondrial transport are altered by pathogenic TUBB4A variants.
Vulinovic F, Krajka V, Hausrat TJ, Seibler P, Alvarez-Fischer D, Madoev H, Park JS, Kumar KR, Sue CM, Lohmann K, Kneussel M, Klein C, Rakovic A. Vulinovic F, et al. Hum Mutat. 2018 Dec;39(12):1901-1915. doi: 10.1002/humu.23602. Epub 2018 Sep 7. Hum Mutat. 2018. PMID: 30079973
TUBB4A encodes the brain-specific beta-tubulin isotype, beta-tubulin 4A. ...We showed that mRNA stability was not affected by any of the TUBB4A variants. Although two mutations (p.R2G and p.D249N) are located at the alpha/beta-tubulin interdimer interface, we confir
TUBB4A encodes the brain-specific beta-tubulin isotype, beta-tubulin 4A. ...We showed that mRNA stability was not affected by any of
Dysregulation of SNHG16(lncRNA)-Hsa-Let-7b-5p(miRNA)-TUBB4A (mRNA) Pathway Fuels Progression of Skin Cutaneous Melanoma.
Chen G, Yan J. Chen G, et al. Curr Protein Pept Sci. 2022;23(11):791-809. doi: 10.2174/1389201023666220928120902. Curr Protein Pept Sci. 2022. PMID: 36173063 Free PMC article.
OBJECTIVE: Skin cutaneous melanoma(SKCM) is the most severe, and complex disease of all skin cancers. The molecular mechanisms of this cancer progression are not well understood. ...The upstream non-coding RNA(ncRNA) acts through the SNHG16-hsa-let-7b-5p-TUBB4A
OBJECTIVE: Skin cutaneous melanoma(SKCM) is the most severe, and complex disease of all skin cancers. The molecular mechanisms of thi …
The influence of hypoxia on the prostate cancer proteome.
Ross JA, Vissers JPC, Nanda J, Stewart GD, Husi H, Habib FK, Hammond DE, Gethings LA. Ross JA, et al. Clin Chem Lab Med. 2020 Jun 25;58(6):980-993. doi: 10.1515/cclm-2019-0626. Clin Chem Lab Med. 2020. PMID: 31940282 Free article.
Prostate cancer accounts for around 15% of male deaths in Western Europe and is the second leading cause of cancer death in men after lung cancer. Mounting evidence suggests that prostate cancer deposits exist within a hypoxic environment and this cont …
Prostate cancer accounts for around 15% of male deaths in Western Europe and is the second leading cause of cancer death in me …
Slug increases sensitivity to tubulin-binding agents via the downregulation of betaIII and betaIVa-tubulin in lung cancer cells.
Tamura D, Arao T, Nagai T, Kaneda H, Aomatsu K, Fujita Y, Matsumoto K, De Velasco MA, Kato H, Hayashi H, Yoshida S, Kimura H, Maniwa Y, Nishio W, Sakai Y, Ohbayashi C, Kotani Y, Nishimura Y, Nishio K. Tamura D, et al. Cancer Med. 2013 Apr;2(2):144-54. doi: 10.1002/cam4.68. Epub 2013 Mar 1. Cancer Med. 2013. PMID: 23634282 Free PMC article.
Transcription factor Slug/SNAI2 (snail homolog 2) plays a key role in the induction of the epithelial mesenchymal transition in cancer cells; however, whether the overexpression of Slug mediates the malignant phenotype and alters drug sensitivity in lung cancer cell …
Transcription factor Slug/SNAI2 (snail homolog 2) plays a key role in the induction of the epithelial mesenchymal transition in cancer
Non-adherent culture induces paclitaxel resistance in H460 lung cancer cells via ERK-mediated up-regulation of betaIVa-tubulin.
Atjanasuppat K, Lirdprapamongkol K, Jantaree P, Svasti J. Atjanasuppat K, et al. Biochem Biophys Res Commun. 2015 Oct 23;466(3):493-8. doi: 10.1016/j.bbrc.2015.09.057. Epub 2015 Sep 12. Biochem Biophys Res Commun. 2015. PMID: 26375501
The chemosensitivity of CTCs appears to correlate with the response of metastatic cancer patients to therapy, but chemoresistance is also frequently observed in advanced stage cancer patients, who have never previously received chemotherapy. ...In conclusion, we sho …
The chemosensitivity of CTCs appears to correlate with the response of metastatic cancer patients to therapy, but chemoresistance is …