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101 results

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Page 1
TSPAN1, a novel tetraspanin member highly involved in carcinogenesis and chemoresistance.
Garcia-Mayea Y, Mir C, Carballo L, Sánchez-García A, Bataller M, LLeonart ME. Garcia-Mayea Y, et al. Biochim Biophys Acta Rev Cancer. 2022 Jan;1877(1):188674. doi: 10.1016/j.bbcan.2021.188674. Epub 2021 Dec 31. Biochim Biophys Acta Rev Cancer. 2022. PMID: 34979155 Review.
Recently, our laboratory revealed a key role of TSPAN1 in the acquired resistance of tumor cells to conventional chemotherapy (e.g., cisplatin). In this review, we summarize and discuss the latest research on the physiological mechanisms of TSPANs in cancer and, in particu …
Recently, our laboratory revealed a key role of TSPAN1 in the acquired resistance of tumor cells to conventional chemotherapy (e.g., …
TSPAN1 promotes autophagy flux and mediates cooperation between WNT-CTNNB1 signaling and autophagy via the MIR454-FAM83A-TSPAN1 axis in pancreatic cancer.
Zhou C, Liang Y, Zhou L, Yan Y, Liu N, Zhang R, Huang Y, Wang M, Tang Y, Ali DW, Wang Y, Michalak M, Chen XZ, Tang J. Zhou C, et al. Autophagy. 2021 Oct;17(10):3175-3195. doi: 10.1080/15548627.2020.1826689. Epub 2020 Oct 22. Autophagy. 2021. PMID: 32972302 Free PMC article.
TSPAN1 expression was correlated with poor overall survival of pancreatic cancer patients. ...We also demonstrated that tspan1 mutation impaired autophagy in the zebrafish model. Furthermore, we showed that TSPAN1 promoted autophagy maturation via direct bind …
TSPAN1 expression was correlated with poor overall survival of pancreatic cancer patients. ...We also demonstrated that tspan1 …
The immunological characteristics of TSPAN1 expressing B cells in autoimmune hepatitis.
Ou Y, Chen R, Qian Q, Cui N, Miao Q, Tang R, You Z, Ma X, Wang Q. Ou Y, et al. Front Immunol. 2022 Dec 15;13:1076594. doi: 10.3389/fimmu.2022.1076594. eCollection 2022. Front Immunol. 2022. PMID: 36591302 Free PMC article.

Moreover, there was a positive correlation between numbers of TSPAN1+ cells and AIH disease severity (P < 0.0001). Immunofluorescence staining further confirmed that TSPAN1 was primarily expressed on CD19+ B cells. Flow-cytometric analysis showed that TSPAN1

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Moreover, there was a positive correlation between numbers of TSPAN1+ cells and AIH disease severity (P < 0.0001). Immunofluoresce

…
TSPAN1 silencing protects against cerulein-induced pancreatic acinar cell injury via targeting AGR2.
Wang J, Huang J, Huang L. Wang J, et al. Drug Dev Res. 2022 Feb;83(1):158-166. doi: 10.1002/ddr.21855. Epub 2021 Jul 1. Drug Dev Res. 2022. PMID: 34212407
Finally, immunoprecipitation (IP) was used to verify the interaction between TSPAN1 and AGR2. TSPAN1 was upregulated in serum of AP patients and AP cell models. ...Hence, TSPAN1 may serve as a promising therapeutic target for AP treatment....
Finally, immunoprecipitation (IP) was used to verify the interaction between TSPAN1 and AGR2. TSPAN1 was upregulated in serum …
TSPAN1: A Novel Protein Involved in Head and Neck Squamous Cell Carcinoma Chemoresistance.
Garcia-Mayea Y, Mir C, Carballo L, Castellvi J, Temprana-Salvador J, Lorente J, Benavente S, García-Pedrero JM, Allonca E, Rodrigo JP, LLeonart ME. Garcia-Mayea Y, et al. Cancers (Basel). 2020 Nov 5;12(11):3269. doi: 10.3390/cancers12113269. Cancers (Basel). 2020. PMID: 33167355 Free PMC article.
Notably, CDDP-resistant tumors showed epithelial-mesenchymal transition (EMT) features that disappeared upon TSPAN1 inhibition, suggesting a link of TSPAN1 with EMT and metastasis. Immunohistochemical analysis of HNSCC specimens further revealed that TSPAN1 e …
Notably, CDDP-resistant tumors showed epithelial-mesenchymal transition (EMT) features that disappeared upon TSPAN1 inhibition, sugge …
TSPAN1 inhibits metastasis of nasopharyngeal carcinoma via suppressing NF-kB signaling.
Wang MD, Li HT, Peng LX, Mei Y, Zheng LS, Li CZ, Meng DF, Lang YH, Xu L, Peng XS, Liu ZJ, Xie DH, Guo LL, Ma MG, Ding LY, Huang BJ, Cao Y, Qian CN. Wang MD, et al. Cancer Gene Ther. 2024 Mar;31(3):454-463. doi: 10.1038/s41417-023-00716-w. Epub 2023 Dec 22. Cancer Gene Ther. 2024. PMID: 38135697
In addition, TSPAN1 was essential in preventing the overactivation of the NF-kB pathway in TSPAN1 overexpressing NPC cells. Furthermore, reduced TSPAN1 expression was associated with NPC metastasis and the poor prognosis of NPC patients. ...
In addition, TSPAN1 was essential in preventing the overactivation of the NF-kB pathway in TSPAN1 overexpressing NPC cells. Fu …
The role of tetraspanins pan-cancer.
Huang R, Sun H, Lin R, Zhang J, Yin H, Xian S, Li M, Wang S, Li Z, Qiao Y, Jiang M, Yan P, Meng T, Huang Z. Huang R, et al. iScience. 2022 Jul 19;25(8):104777. doi: 10.1016/j.isci.2022.104777. eCollection 2022 Aug 19. iScience. 2022. PMID: 35992081 Free PMC article.
The precise functions of TSPANs and their roles in pan-cancer are unclear. In this work, we analyzed TSPAN1, TSPAN10, TSPAN11, TSPAN12, TSPAN13, TSPAN14, TSPAN15, TSPAN16, TSPAN17, TSPAN18, TSPAN18-AS1, TSPAN19, TSPAN2, TSPAN3, TSPAN31, TSPAN32, TSPAN33, TSPAN4, TSPAN5, TS …
The precise functions of TSPANs and their roles in pan-cancer are unclear. In this work, we analyzed TSPAN1, TSPAN10, TSPAN11, TSPAN1 …
TSPAN1 upregulates MMP2 to promote pancreatic cancer cell migration and invasion via PLCgamma.
Zhang X, Shi G, Gao F, Liu P, Wang H, Tan X. Zhang X, et al. Oncol Rep. 2019 Apr;41(4):2117-2125. doi: 10.3892/or.2019.6989. Epub 2019 Jan 30. Oncol Rep. 2019. PMID: 30720116 Free PMC article.
The effect of TSPAN1 downregulation and overexpression in PC cells, via transfection with siRNA and pLNCX-TSPAN1-cDNA recombinant plasmid, respectively, on cell invasion and migration were assessed. ...TSPAN1 was also highly expressed in PC cell lines compare …
The effect of TSPAN1 downregulation and overexpression in PC cells, via transfection with siRNA and pLNCX-TSPAN1-cDNA recombin …
TSPAN1 functions as an oncogene in gastric cancer and is downregulated by miR-573.
Lu Z, Luo T, Nie M, Pang T, Zhang X, Shen X, Ma L, Bi J, Wei G, Fang G, Xue X. Lu Z, et al. FEBS Lett. 2015 Jul 8;589(15):1988-94. doi: 10.1016/j.febslet.2015.05.044. Epub 2015 Jun 6. FEBS Lett. 2015. PMID: 26054975 Free article.
Tetraspanin 1 (TSPAN1) has been reported to be upregulated in gastric cancer (GC). ...We identified TSPAN1 as a novel target gene of miR-573. Overexpression of miR-573 suppressed proliferation and invasion of GC cells by down-regulation of TSPAN1 expression. …
Tetraspanin 1 (TSPAN1) has been reported to be upregulated in gastric cancer (GC). ...We identified TSPAN1 as a novel target g …
TSPAN1-elevated FAM110A promotes pancreatic cancer progression by transcriptionally regulating HIST1H2BK.
Huang H, Li H, Zhao T, Khan AA, Pan R, Wang S, Wang S, Liu X. Huang H, et al. J Cancer. 2022 Jan 1;13(3):906-917. doi: 10.7150/jca.66404. eCollection 2022. J Cancer. 2022. PMID: 35154458 Free PMC article.
Moreover, for the first time, we revealed the oncogenic role of HIST1H2BK in pancreatic cancer, and the tumor-promoting capacity of HIST1H2BK may be associated with its regulatory effect on G9a. In addition, we demonstrated that TSPAN1 displayed a positive transcriptional …
Moreover, for the first time, we revealed the oncogenic role of HIST1H2BK in pancreatic cancer, and the tumor-promoting capacity of HIST1H2B …
101 results