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668 results

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Page 1
The complexity of TRIM28 contribution to cancer.
Czerwińska P, Mazurek S, Wiznerowicz M. Czerwińska P, et al. J Biomed Sci. 2017 Aug 29;24(1):63. doi: 10.1186/s12929-017-0374-4. J Biomed Sci. 2017. PMID: 28851455 Free PMC article. Review.
In this review, we summarize core biological functions of TRIM28 that emerge from TRIM28 multi-domain structure and possessed enzymatic activities. Moreover, we will discuss whether the complexity of TRIM28 engagement in cancer biology makes TRIM28 a p …
In this review, we summarize core biological functions of TRIM28 that emerge from TRIM28 multi-domain structure and possessed …
The SETDB1-TRIM28 Complex Suppresses Antitumor Immunity.
Lin J, Guo D, Liu H, Zhou W, Wang C, Müller I, Kossenkov AV, Drapkin R, Bitler BG, Helin K, Zhang R. Lin J, et al. Cancer Immunol Res. 2021 Dec;9(12):1413-1424. doi: 10.1158/2326-6066.CIR-21-0754. Cancer Immunol Res. 2021. PMID: 34848497 Free PMC article.
The tumor immune microenvironment is influenced by the epigenetic landscape of the tumor. Here, we have identified the SETDB1-TRIM28 complex as a critical suppressor of antitumor immunity. An epigenetic CRISPR-Cas9 screen of 1,218 chromatin regulators identified TRIM28 …
The tumor immune microenvironment is influenced by the epigenetic landscape of the tumor. Here, we have identified the SETDB1-TRIM28 …
TRIM28 promotes the escape of gastric cancer cells from immune surveillance by increasing PD-L1 abundance.
Ma X, Jia S, Wang G, Liang M, Guo T, Du H, Li S, Li X, Huangfu L, Guo J, Xing X, Ji J. Ma X, et al. Signal Transduct Target Ther. 2023 Jun 26;8(1):246. doi: 10.1038/s41392-023-01450-3. Signal Transduct Target Ther. 2023. PMID: 37357254 Free PMC article.
It was found that TRIM28 was positively correlated with PD-L1 in G.C. cells. Moreover, high TRIM28 expression suggests poor survival in a cohort of 466 patients with G.C., and this observation is consistent while analyzing data from publicly available databases. Ect …
It was found that TRIM28 was positively correlated with PD-L1 in G.C. cells. Moreover, high TRIM28 expression suggests poor su …
TRIM28 SUMOylates and stabilizes NLRP3 to facilitate inflammasome activation.
Qin Y, Li Q, Liang W, Yan R, Tong L, Jia M, Zhao C, Zhao W. Qin Y, et al. Nat Commun. 2021 Aug 9;12(1):4794. doi: 10.1038/s41467-021-25033-4. Nat Commun. 2021. PMID: 34373456 Free PMC article.
TRIM28 binds NLRP3, promotes SUMO1, SUMO2 and SUMO3 modification of NLRP3, and thereby inhibits NLRP3 ubiquitination and proteasomal degradation. Concordantly, Trim28 deficiency attenuates NLRP3 inflammasome activation both in vitro and in vivo. ...
TRIM28 binds NLRP3, promotes SUMO1, SUMO2 and SUMO3 modification of NLRP3, and thereby inhibits NLRP3 ubiquitination and proteasomal …
TRIM28 variants and Wilms' tumour predisposition.
Hol JA, Diets IJ, de Krijger RR, van den Heuvel-Eibrink MM, Jongmans MC, Kuiper RP. Hol JA, et al. J Pathol. 2021 Jul;254(4):494-504. doi: 10.1002/path.5639. Epub 2021 Mar 15. J Pathol. 2021. PMID: 33565090 Free PMC article. Review.
TRIM28 variants are associated with epithelial WT, but the presence of other tumour components or anaplasia does not exclude the presence of a germline or somatic TRIM28 variant. ...Therefore, loss of TRIM28 (KAP1/TIF1beta) protein expression in tumour tissue …
TRIM28 variants are associated with epithelial WT, but the presence of other tumour components or anaplasia does not exclude the pres …
TRIM28 and the control of transposable elements in the brain.
Grassi DA, Jönsson ME, Brattås PL, Jakobsson J. Grassi DA, et al. Brain Res. 2019 Feb 15;1705:43-47. doi: 10.1016/j.brainres.2018.02.043. Epub 2018 Mar 6. Brain Res. 2019. PMID: 29522722 Review.
TRIM28 is an epigenetic co-repressor protein that mediates transcriptional silencing. ...Recent advances indicate that TRIM28-based repression of TEs occurs in the mammalian brain and may provide beneficial effects through the regulation of transcriptional networks. …
TRIM28 is an epigenetic co-repressor protein that mediates transcriptional silencing. ...Recent advances indicate that TRIM28- …
KAP1/TRIM28: Transcriptional Activator and/or Repressor of Viral and Cellular Programs?
Randolph K, Hyder U, D'Orso I. Randolph K, et al. Front Cell Infect Microbiol. 2022 Feb 23;12:834636. doi: 10.3389/fcimb.2022.834636. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 35281453 Free PMC article. Review.
One such regulator is Kruppel-associated box (KRAB)-associated protein 1 (KAP1: also named TRIM28 or TIF1beta), which has been extensively studied in the past three decades. ...
One such regulator is Kruppel-associated box (KRAB)-associated protein 1 (KAP1: also named TRIM28 or TIF1beta), which has been extens …
RIPK3 activation induces TRIM28 derepression in cancer cells and enhances the anti-tumor microenvironment.
Park HH, Kim HR, Park SY, Hwang SM, Hong SM, Park S, Kang HC, Morgan MJ, Cha JH, Lee D, Roe JS, Kim YS. Park HH, et al. Mol Cancer. 2021 Aug 21;20(1):107. doi: 10.1186/s12943-021-01399-3. Mol Cancer. 2021. PMID: 34419074 Free PMC article.
The cell composition estimation module was used to evaluate the correlation between RIPK3/TRIM28 levels and CD8(+) T cells or dendritic cells (DC) in all TCGA tumors. RESULTS: We identified TRIM28 as a co-repressor that regulates transcriptional activity during necr …
The cell composition estimation module was used to evaluate the correlation between RIPK3/TRIM28 levels and CD8(+) T cells or dendrit …
TRIM28 represses renal cell carcinoma cell proliferation by inhibiting TFE3/KDM6A-regulated autophagy.
Song T, Lv S, Ma X, Zhao X, Fan L, Zou Q, Li N, Yan Y, Zhang W, Sun L. Song T, et al. J Biol Chem. 2023 May;299(5):104621. doi: 10.1016/j.jbc.2023.104621. Epub 2023 Mar 18. J Biol Chem. 2023. PMID: 36935008 Free PMC article.
Mechanisms of autophagy dysregulation in cancer remain elusive. Loss of function of TRIM28, a multifunction protein, is seen in familial kidney malignancy, but the mechanism by which TRIM28 contributes to the etiology of kidney malignancy is unclear. In this study, …
Mechanisms of autophagy dysregulation in cancer remain elusive. Loss of function of TRIM28, a multifunction protein, is seen in famil …
TRIM28 modulates nuclear receptor signaling to regulate uterine function.
Li R, Wang T, Marquardt RM, Lydon JP, Wu SP, DeMayo FJ. Li R, et al. Nat Commun. 2023 Aug 1;14(1):4605. doi: 10.1038/s41467-023-40395-7. Nat Commun. 2023. PMID: 37528140 Free PMC article.
Furthermore, TRIM28 ablation in PR-expressing uterine cells results in the enrichment of a subset of TRIM28 positive and PR negative pericytes and epithelial cells with progenitor potential. In summary, our study reveals the important roles of TRIM28 in regul …
Furthermore, TRIM28 ablation in PR-expressing uterine cells results in the enrichment of a subset of TRIM28 positive and PR ne …
668 results