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Page 1
Tmod3 Phosphorylation Mediates AMPK-Dependent GLUT4 Plasma Membrane Insertion in Myoblasts.
Shrestha MM, Lim CY, Bi X, Robinson RC, Han W. Shrestha MM, et al. Front Endocrinol (Lausanne). 2021 Apr 20;12:653557. doi: 10.3389/fendo.2021.653557. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 33959097 Free PMC article.
We performed biochemical, molecular biology and fluorescent microscopy imaging experiments using gain- and loss-of-function mutants of tropomodulin 3 (Tmod3). Here we report Tmod3, an actin filament capping protein, as a novel AMPK substrate and an essential mediato …
We performed biochemical, molecular biology and fluorescent microscopy imaging experiments using gain- and loss-of-function mutants of tropo …
Tmod3 regulates polarized epithelial cell morphology.
Weber KL, Fischer RS, Fowler VM. Weber KL, et al. J Cell Sci. 2007 Oct 15;120(Pt 20):3625-32. doi: 10.1242/jcs.011445. J Cell Sci. 2007. PMID: 17928307
Tmod3 localizes to lateral cell membranes in polarized epithelia of several cell types. ...Instead, distribution of alphaII-spectrin on lateral membranes is disrupted upon reduction of Tmod3 levels, suggesting that loss of Tmod3 function leads to destabilizat …
Tmod3 localizes to lateral cell membranes in polarized epithelia of several cell types. ...Instead, distribution of alphaII-spectrin …
Identification of tumor antigens and immune subtypes of pancreatic adenocarcinoma for mRNA vaccine development.
Huang X, Zhang G, Tang T, Liang T. Huang X, et al. Mol Cancer. 2021 Mar 1;20(1):44. doi: 10.1186/s12943-021-01310-0. Mol Cancer. 2021. PMID: 33648511 Free PMC article.
RESULTS: Six overexpressed and mutated tumor antigens associated with poor prognosis and infiltration of antigen presenting cells were identified in PAAD, including ADAM9, EFNB2, MET, TMOD3, TPX2, and WNT7A. Furthermore, five immune subtypes (IS1-IS5) and nine immune gene …
RESULTS: Six overexpressed and mutated tumor antigens associated with poor prognosis and infiltration of antigen presenting cells were ident …
Multifunctional roles of tropomodulin-3 in regulating actin dynamics.
Parreno J, Fowler VM. Parreno J, et al. Biophys Rev. 2018 Dec;10(6):1605-1615. doi: 10.1007/s12551-018-0481-9. Epub 2018 Nov 14. Biophys Rev. 2018. PMID: 30430457 Free PMC article. Review.
Here, we highlight the multifunctional roles of Tmod with a focus on Tmod3. Like other Tmods, Tmod3 binds tropomyosin (Tpm) and actin, capping pure F-actin at submicromolar and Tpm-coated F-actin at nanomolar concentrations. Unlike other Tmods, Tmod3 can also …
Here, we highlight the multifunctional roles of Tmod with a focus on Tmod3. Like other Tmods, Tmod3 binds tropomyosin (Tpm) an …
Erythroid differentiation in mouse erythroleukemia cells depends on Tmod3-mediated regulation of actin filament assembly into the erythroblast membrane skeleton.
Ghosh A, Coffin M, West R, Fowler VM. Ghosh A, et al. FASEB J. 2022 Mar;36(3):e22220. doi: 10.1096/fj.202101011R. FASEB J. 2022. PMID: 35195928
To further decipher Tmod3's function during ED, we generated a Tmod3 knockout in a mouse erythroleukemia cell line (Mel ds19). ...Tmod3 does not assemble with Tmod1 and Tpms into the Triton X-100 insoluble membrane skeleton during ED, and loss of Tmod3 …
To further decipher Tmod3's function during ED, we generated a Tmod3 knockout in a mouse erythroleukemia cell line (Mel ds19). …
MicroRNA-145 Regulates Pathological Retinal Angiogenesis by Suppression of TMOD3.
Liu CH, Wang Z, Huang S, Sun Y, Chen J. Liu CH, et al. Mol Ther Nucleic Acids. 2019 Jun 7;16:335-347. doi: 10.1016/j.omtn.2019.03.001. Epub 2019 Mar 21. Mol Ther Nucleic Acids. 2019. PMID: 30981984 Free PMC article.
Treatment with miR-145 mimic led to TMOD3 inhibition, altered actin cytoskeletal architecture, and elongation of ECs. Moreover, inhibition of TMOD3 promoted EC angiogenic function and pathological neovascularization in OIR and abolished the vascular effects of miR-1 …
Treatment with miR-145 mimic led to TMOD3 inhibition, altered actin cytoskeletal architecture, and elongation of ECs. Moreover, inhib …
MicroRNA-490-3p suppresses the proliferation and invasion of hepatocellular carcinoma cells via targeting TMOD3.
Wang H, Yang G, Yu Y, Gu P. Wang H, et al. Oncol Lett. 2020 Oct;20(4):95. doi: 10.3892/ol.2020.11956. Epub 2020 Aug 6. Oncol Lett. 2020. PMID: 32831914 Free PMC article.
Furthermore, a luciferase activity assay was used to verify the association between miR-490-3p and its predicted target tropomodulin 3 (TMOD3). In addition, the protein levels of Bax, Bcl-2, cleaved caspase-3, TMOD3, phosphorylated (p)-p38 and p-ERK in HCC cells wer …
Furthermore, a luciferase activity assay was used to verify the association between miR-490-3p and its predicted target tropomodulin 3 (T …
Cleavage of tropomodulin-3 by asparagine endopeptidase promotes cancer malignancy by actin remodeling and SND1/RhoA signaling.
Chen B, Wang M, Qiu J, Liao K, Zhang W, Lv Q, Ma C, Qian Z, Shi Z, Liang R, Lin Y, Ye J, Qiu Y, Lin Y. Chen B, et al. J Exp Clin Cancer Res. 2022 Jun 28;41(1):209. doi: 10.1186/s13046-022-02411-4. J Exp Clin Cancer Res. 2022. PMID: 35765111 Free PMC article.
Truncated Tmod3 was detected in diverse tumors and was found to be associated with poor prognosis of high-grade glioma. ...CONCLUSION: The newly identified AEP-Tmod3 protease signaling axis is a novel "dual-regulation" mechanism of tumor cell proliferation and migra …
Truncated Tmod3 was detected in diverse tumors and was found to be associated with poor prognosis of high-grade glioma. ...CONCLUSION …
MiR-145 modulates the radiosensitivity of non-small cell lung cancer cells by suppression of TMOD3.
Li H, Zhao S, Chen X, Feng G, Chen Z, Fan S. Li H, et al. Carcinogenesis. 2022 Apr 25;43(3):288-296. doi: 10.1093/carcin/bgab121. Carcinogenesis. 2022. PMID: 34888652
Mechanically, miR-145 was able to directly target 3'UTR of tropomodulin 3 (TMOD3) mRNA and decrease the expression of TMOD3 at the levels of mRNA and protein. ...Collectively, restoration of miR-145 expression increases the radiosensitivity of radioresistant NSCLC c …
Mechanically, miR-145 was able to directly target 3'UTR of tropomodulin 3 (TMOD3) mRNA and decrease the expression of TMOD3 at …
Clinicopathological Characteristics, Prognosis, and Correlated Tumor Cell Function of Tropomodulin-3 in Pancreatic Adenocarcinoma.
Zhong B, Ma DD, Zhang T, Gong Q, Dong YI, Zhang JX, Li ZH, Jin WD. Zhong B, et al. Comb Chem High Throughput Screen. 2023 Aug 10. doi: 10.2174/1386207326666230810142646. Online ahead of print. Comb Chem High Throughput Screen. 2023. PMID: 37563820

We also conducted in vitro cell experiments to explore the effects of TMOD3 on the function of PAAD cells. RESULTS: TMOD3 expression was found to be significantly higher in PAAD tissues than in matched paracancerous tissues (P < 0.05). Meanwhile, high TMOD3

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We also conducted in vitro cell experiments to explore the effects of TMOD3 on the function of PAAD cells. RESULTS: TMOD3 expr …
60 results