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2008 1
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TM9SF4 is an F-actin disassembly factor that promotes tumor progression and metastasis.
Meng Z, Li Z, Xie M, Yu H, Jiang L, Yao X. Meng Z, et al. Nat Commun. 2022 Sep 29;13(1):5728. doi: 10.1038/s41467-022-33276-y. Nat Commun. 2022. PMID: 36175399 Free PMC article.
In vivo, knockdown of TM9SF4 completely abolishes the tumor growth and metastasis in athymic nude mice. These data provide mechanistic insights into TM9SF4-mediated regulation of actin dynamics in ovarian cancer cells....
In vivo, knockdown of TM9SF4 completely abolishes the tumor growth and metastasis in athymic nude mice. These data provide mechanisti …
TM9SF4 Is a Crucial Regulator of Inflammation and ER Stress in Inflammatory Bowel Disease.
Xie M, Mak JWY, Yu H, Cheng CTY, Chan HCH, Chan TT, Lau LHS, Wong MTL, Ko WH, Jiang L, Yao X. Xie M, et al. Cell Mol Gastroenterol Hepatol. 2022;14(2):245-270. doi: 10.1016/j.jcmgh.2022.04.002. Epub 2022 Apr 7. Cell Mol Gastroenterol Hepatol. 2022. PMID: 35398597 Free PMC article.
RESULTS: In mouse models of IBD, genetic knockout of the TM9SF4 gene aggravated the disease symptoms. In colonic epithelial cells, short hairpin RNA-mediated knockdown of TM9SF4 expression promoted inflammation and increased ER stress. ...Genetic knockout/knockdown …
RESULTS: In mouse models of IBD, genetic knockout of the TM9SF4 gene aggravated the disease symptoms. In colonic epithelial cells, sh …
TM9SF4 is a novel regulator in lineage commitment of bone marrow mesenchymal stem cells to either osteoblasts or adipocytes.
Yu L, Xie M, Zhang F, Wan C, Yao X. Yu L, et al. Stem Cell Res Ther. 2021 Nov 13;12(1):573. doi: 10.1186/s13287-021-02636-8. Stem Cell Res Ther. 2021. PMID: 34774100 Free PMC article.
METHODS: Primary bone marrow MSCs, isolated from TM9SF4 wildtype (TM9SF4(+/+)) and knockout (TM9SF4(-/-)) mice, were induced to differentiate into osteoblasts or adipocytes, respectively. ...Furthermore, TM9SF4-depleted cells showed higher activity of …
METHODS: Primary bone marrow MSCs, isolated from TM9SF4 wildtype (TM9SF4(+/+)) and knockout (TM9SF4(-/-)) mice, were in …
CircCEMIP promotes anoikis-resistance by enhancing protective autophagy in prostate cancer cells.
Yu Y, Song Y, Cheng L, Chen L, Liu B, Lu D, Li X, Li Y, Lv F, Xing Y. Yu Y, et al. J Exp Clin Cancer Res. 2022 Jun 2;41(1):188. doi: 10.1186/s13046-022-02381-7. J Exp Clin Cancer Res. 2022. PMID: 35655258 Free PMC article.
Furthermore, target prediction and dual-luciferase reporter assays identified transmembrane 9 superfamily member 4 (TM9SF4) as a potential miR-1248 target. Pathway analysis revealed that TM9SF4 activated autophagy to promote PCa cells anoikis resistance via mTOR pho …
Furthermore, target prediction and dual-luciferase reporter assays identified transmembrane 9 superfamily member 4 (TM9SF4) as a pote …
TM9SF4 expression in tumor tissues: a novel diagnostic biomarker for gastrointestinal tumors.
Guazzi P, Zocco D, Isajevs S, Zarovni N, Bianciardi L, Toots M, Sivins A, Leja M, Chiesi A, Lozupone F. Guazzi P, et al. Transl Cancer Res. 2020 Nov;9(11):6652-6659. doi: 10.21037/tcr-20-516. Transl Cancer Res. 2020. PMID: 35117275 Free PMC article.
METHODS: In this study, we detected by immunohistochemistry (IHC) in tumor and surrounding healthy tissues TM9SF4, in comparison with clinically adopted biomarkers CEA and CA 19-9 to evaluate TM9SF4 potential as a novel tissue marker for early detection and monitori …
METHODS: In this study, we detected by immunohistochemistry (IHC) in tumor and surrounding healthy tissues TM9SF4, in comparison with …
TM9SF4 is a novel factor promoting autophagic flux under amino acid starvation.
Sun L, Meng Z, Zhu Y, Lu J, Li Z, Zhao Q, Huang Y, Jiang L, Yao X. Sun L, et al. Cell Death Differ. 2018 Feb;25(2):368-379. doi: 10.1038/cdd.2017.166. Epub 2017 Nov 10. Cell Death Differ. 2018. PMID: 29125601 Free PMC article.
Knockdown of TM9SF4 with TM9SF4-shRNAs markedly reduced the starvation-induced autophagy in HEK293 cells, the effect of which persisted in the presence of bafilomycin A1. TM9SF4-shRNAs also substantially attenuated the starvation-induced mTOR inactivation. .. …
Knockdown of TM9SF4 with TM9SF4-shRNAs markedly reduced the starvation-induced autophagy in HEK293 cells, the effect of which …
TM9SF4 levels determine sorting of transmembrane domains in the early secretory pathway.
Vernay A, Lamrabet O, Perrin J, Cosson P. Vernay A, et al. J Cell Sci. 2018 Nov 5;131(21):jcs220830. doi: 10.1242/jcs.220830. J Cell Sci. 2018. PMID: 30301779
These results show that TM9SF4 controls the sorting of TMDs at the ER-Golgi interface. Remarkably, sorting of T-R1 in HCT116 cells was different from that in HEK cells: in HCT116 cells, a substantial fraction of T-R1 was localized to the Golgi complex, and it was relocated …
These results show that TM9SF4 controls the sorting of TMDs at the ER-Golgi interface. Remarkably, sorting of T-R1 in HCT116 cells wa …
Human TM9SF4 Is a New Gene Down-Regulated by Hypoxia and Involved in Cell Adhesion of Leukemic Cells.
Paolillo R, Spinello I, Quaranta MT, Pasquini L, Pelosi E, Lo Coco F, Testa U, Labbaye C. Paolillo R, et al. PLoS One. 2015 May 11;10(5):e0126968. doi: 10.1371/journal.pone.0126968. eCollection 2015. PLoS One. 2015. PMID: 25961573 Free PMC article.
BACKGROUND: The transmembrane 9 superfamily protein member 4, TM9SF4, belongs to the TM9SF family of proteins highly conserved through evolution. ...Then, we found that the hypoxia-mediated downregulation of TM9SF4 expression is associated with a decrease of cell ad …
BACKGROUND: The transmembrane 9 superfamily protein member 4, TM9SF4, belongs to the TM9SF family of proteins highly conserved throug …
Knockdown of TM9SF4 boosts ER stress to trigger cell death of chemoresistant breast cancer cells.
Zhu Y, Xie M, Meng Z, Leung LK, Chan FL, Hu X, Chi K, Liu C, Yao X. Zhu Y, et al. Oncogene. 2019 Jul;38(29):5778-5791. doi: 10.1038/s41388-019-0846-y. Epub 2019 Jun 27. Oncogene. 2019. PMID: 31249383
Knockdown of TM9SF4 also reduced cell growth and triggered cell death in chemoresistant MDA-MB-231/GEM cells. ...These results highlight a possible strategy of targeting TM9SF4 to overcome breast cancer chemoresistance....
Knockdown of TM9SF4 also reduced cell growth and triggered cell death in chemoresistant MDA-MB-231/GEM cells. ...These results highli …
TM9SF4 is a novel V-ATPase-interacting protein that modulates tumor pH alterations associated with drug resistance and invasiveness of colon cancer cells.
Lozupone F, Borghi M, Marzoli F, Azzarito T, Matarrese P, Iessi E, Venturi G, Meschini S, Canitano A, Bona R, Cara A, Fais S. Lozupone F, et al. Oncogene. 2015 Oct 1;34(40):5163-74. doi: 10.1038/onc.2014.437. Epub 2015 Feb 9. Oncogene. 2015. PMID: 25659576
Here, we demonstrate that TM9SF4 represents a novel V-ATPase-associated protein involved in V-ATPase activation. We have observed in HCT116 and SW480 colon cancer cell lines that TM9SF4 interacts with the ATP6V1H subunit of the V-ATPase V1 sector. ...
Here, we demonstrate that TM9SF4 represents a novel V-ATPase-associated protein involved in V-ATPase activation. We have observed in …
27 results