TM9SF4 Is a Crucial Regulator of Inflammation and ER Stress in Inflammatory Bowel Disease.
Xie M, Mak JWY, Yu H, Cheng CTY, Chan HCH, Chan TT, Lau LHS, Wong MTL, Ko WH, Jiang L, Yao X.
Xie M, et al.
Cell Mol Gastroenterol Hepatol. 2022;14(2):245-270. doi: 10.1016/j.jcmgh.2022.04.002. Epub 2022 Apr 7.
Cell Mol Gastroenterol Hepatol. 2022.
PMID: 35398597
Free PMC article.
RESULTS: In mouse models of IBD, genetic knockout of the TM9SF4 gene aggravated the disease symptoms. In colonic epithelial cells, short hairpin RNA-mediated knockdown of TM9SF4 expression promoted inflammation and increased ER stress. ...Genetic knockout/knockdown …
RESULTS: In mouse models of IBD, genetic knockout of the TM9SF4 gene aggravated the disease symptoms. In colonic epithelial cells, sh …