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T-cell activation is an immune correlate of risk in BCG vaccinated infants.
Fletcher HA, Snowden MA, Landry B, Rida W, Satti I, Harris SA, Matsumiya M, Tanner R, O'Shea MK, Dheenadhayalan V, Bogardus L, Stockdale L, Marsay L, Chomka A, Harrington-Kandt R, Manjaly-Thomas ZR, Naranbhai V, Stylianou E, Darboe F, Penn-Nicholson A, Nemes E, Hatherill M, Hussey G, Mahomed H, Tameris M, McClain JB, Evans TG, Hanekom WA, Scriba TJ, McShane H. Fletcher HA, et al. Nat Commun. 2016 Apr 12;7:11290. doi: 10.1038/ncomms11290. Nat Commun. 2016. PMID: 27068708 Free PMC article. Clinical Trial.
We performed a case-control analysis to identify immune correlates of TB disease risk in Bacille Calmette-Guerin (BCG) immunized infants from the MVA85A efficacy trial. ...The causes and impact of T-cell activation on …
We performed a case-control analysis to identify immune correlates of TB disease risk in Bacille Calmette-Guerin (BC …
Tuberculosis susceptibility and protection in children.
Basu Roy R, Whittaker E, Seddon JA, Kampmann B. Basu Roy R, et al. Lancet Infect Dis. 2019 Mar;19(3):e96-e108. doi: 10.1016/S1473-3099(18)30157-9. Epub 2018 Oct 12. Lancet Infect Dis. 2019. PMID: 30322790 Free PMC article. Review.
Children aged 5-10 years are somewhat protected, until risk increases again in adolescence. Furthermore, neonatal BCG programmes show the clearest proven benefit of vaccination against tuberculosis. Case-control comparisons from key cohorts, which recruited m …
Children aged 5-10 years are somewhat protected, until risk increases again in adolescence. Furthermore, neonatal BCG programm …
Corrigendum: T-cell activation is an immune correlate of risk in BCG vaccinated infants.
Fletcher HA, Snowden MA, Landry B, Rida W, Satti I, Harris SA, Matsumiya M, Tanner R, O'Shea MK, Dheenadhayalan V, Bogardus L, Stockdale L, Marsay L, Chomka A, Harrington-Kandt R, Manjaly-Thomas ZR, Naranbhai V, Stylianou E, Darboe F, Penn-Nicholson A, Nemes E, Hatherill M, Hussey G, Mahomed H, Tameris M, McClain JB, Evans TG, Hanekom WA, Scriba TJ, McShane H. Fletcher HA, et al. Nat Commun. 2016 May 6;7:11633. doi: 10.1038/ncomms11633. Nat Commun. 2016. PMID: 27151680 Free PMC article. No abstract available.
Impact of SIV infection on mycobacterial lipid-reactive T cell responses in Bacillus Calmette-Guerin (BCG) inoculated macaques.
Walker EM, Merino KM, Slisarenko N, Grasperge BF, Mehra S, Roy CJ, Kaushal D, Rout N. Walker EM, et al. Front Immunol. 2023 Jan 16;13:1085786. doi: 10.3389/fimmu.2022.1085786. eCollection 2022. Front Immunol. 2023. PMID: 36726992 Free PMC article.
BACKGROUND: Although BCG vaccine protects infants from tuberculosis (TB), it has limited efficacy in adults against pulmonary TB. Further, HIV coinfection significantly increases the risk of developing active TB. In the lack of defined correl …
BACKGROUND: Although BCG vaccine protects infants from tuberculosis (TB), it has limited efficacy in adults against pul …
Genome wide approaches discover novel Mycobacterium tuberculosis antigens as correlates of infection, disease, immunity and targets for vaccination.
Coppola M, Ottenhoff TH. Coppola M, et al. Semin Immunol. 2018 Oct;39:88-101. doi: 10.1016/j.smim.2018.07.001. Epub 2018 Jul 7. Semin Immunol. 2018. PMID: 30327124 Free article. Review.
Currently, it is estimated that one-fourth of the human population is latently infected with Mtb and among those infected 3-10% are at risk of developing active TB disease during their lifetime. The currently available diagnostics are not able to detect this risk …
Currently, it is estimated that one-fourth of the human population is latently infected with Mtb and among those infected 3-10% are at ri …