Silibinin inhibits the toxic aggregation of human islet amyloid polypeptide.
Biochem Biophys Res Commun. 2012.
PMID: 22366091
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Silibinin inhibits the toxic aggregation of human islet amyloid polypeptide.
Cheng B, Gong H, Li X, Sun Y, Zhang X, Chen H, Liu X, Zheng L, Huang K.
Cheng B, et al.
Biochem Biophys Res Commun. 2012 Mar 16;419(3):495-9. doi: 10.1016/j.bbrc.2012.02.042. Epub 2012 Feb 14.
Biochem Biophys Res Commun. 2012.
PMID: 22366091
In type 2 diabetes mellitus (T2DM), misfolded human islet amyloid polypeptide (hIAPP) forms amyloid deposits in pancreatic islets. ...In this study, we tested whether silibinin has any effect on the amyloidogenicity of hIAPP. Our results …
In type 2 diabetes mellitus (T2DM), misfolded human islet amyloid polypeptide (hIAPP) forms amyloid depos …
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Revealing the Mechanism of EGCG, Genistein, Rutin, Quercetin, and Silibinin Against hIAPP Aggregation via Computational Simulations.
Wang Y, Lv Y, Jin L, Liang G.
Wang Y, et al.
Interdiscip Sci. 2020 Mar;12(1):59-68. doi: 10.1007/s12539-019-00352-9. Epub 2020 Jan 1.
Interdiscip Sci. 2020.
PMID: 31894470
To inhibit hIAPP aggregation and reduce toxicity of its oligomers are one of the potential strategies for the treatment of Type 2 diabetes (T2D). ...However, the detailed mechanisms to inhibit hIAPP aggregation remain unclear. Here, we explore t …
To inhibit hIAPP aggregation and reduce toxicity of its oligomers are one of the potential strategies for the treatment …
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Silybins inhibit human IAPP amyloid growth and toxicity through stereospecific interactions.
García-Viñuales S, Ilie IM, Santoro AM, Romanucci V, Zarrelli A, Di Fabio G, Caflisch A, Milardi D.
García-Viñuales S, et al.
Biochim Biophys Acta Proteins Proteom. 2022 May 1;1870(5):140772. doi: 10.1016/j.bbapap.2022.140772. Epub 2022 Mar 17.
Biochim Biophys Acta Proteins Proteom. 2022.
PMID: 35307557
Free article.
Type 2 Diabetes is a major public health threat, and its prevalence is increasing worldwide. The abnormal accumulation of islet amyloid polypeptide (IAPP) in pancreatic beta-cells is associated with the onset of the disease. ...We show that Silybin B …
Type 2 Diabetes is a major public health threat, and its prevalence is increasing worldwide. The abnormal accumulation of islet am …
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