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Page 1
Epigenetic quantification of tumor-infiltrating T-lymphocytes.
Sehouli J, Loddenkemper C, Cornu T, Schwachula T, Hoffmüller U, Grützkau A, Lohneis P, Dickhaus T, Gröne J, Kruschewski M, Mustea A, Turbachova I, Baron U, Olek S. Sehouli J, et al. Among authors: schwachula t. Epigenetics. 2011 Feb;6(2):236-46. doi: 10.4161/epi.6.2.13755. Epub 2011 Feb 1. Epigenetics. 2011. PMID: 20962591 Free PMC article.
Regulatory T cells are not a strong predictor of survival for patients with glioblastoma.
Thomas AA, Fisher JL, Rahme GJ, Hampton TH, Baron U, Olek S, Schwachula T, Rhodes CH, Gui J, Tafe LJ, Tsongalis GJ, Lefferts JA, Wishart H, Kleen J, Miller M, Whipple CA, de Abreu FB, Ernstoff MS, Fadul CE. Thomas AA, et al. Among authors: schwachula t. Neuro Oncol. 2015 Jun;17(6):801-9. doi: 10.1093/neuonc/nou363. Epub 2015 Jan 24. Neuro Oncol. 2015. PMID: 25618892 Free PMC article.
High immune response rates and decreased frequencies of regulatory T cells in metastatic renal cell carcinoma patients after tumor cell vaccination.
Pohla H, Buchner A, Stadlbauer B, Frankenberger B, Stevanovic S, Walter S, Frank R, Schwachula T, Olek S, Kopp J, Willimsky G, Stief CG, Hofstetter A, Pezzutto A, Blankenstein T, Oberneder R, Schendel DJ. Pohla H, et al. Among authors: schwachula t. Mol Med. 2013 Feb 8;18(1):1499-508. doi: 10.2119/molmed.2012.00221. Mol Med. 2013. PMID: 23269976 Free PMC article. Clinical Trial.
The cellular ratio of immune tolerance (immunoCRIT) is a definite marker for aggressiveness of solid tumors and may explain tumor dissemination patterns.
Türbachova I, Schwachula T, Vasconcelos I, Mustea A, Baldinger T, Jones KA, Bujard H, Olek A, Olek K, Gellhaus K, Braicu I, Könsgen D, Fryer C, Ravot E, Hellwag A, Westerfeld N, Gruss OJ, Meissner M, Hasan MT, Weber M, Hoffmüller U, Zimmermann S, Loddenkemper C, Mahner S, Babel N, Berns E, Adams R, Zeilinger R, Baron U, Vergote I, Maughan T, Marme F, Dickhaus T, Sehouli J, Olek S. Türbachova I, et al. Among authors: schwachula t. Epigenetics. 2013 Nov;8(11):1226-35. doi: 10.4161/epi.26334. Epub 2013 Sep 26. Epigenetics. 2013. PMID: 24071829
BRCA1 gene promoter methylation status in high-grade serous ovarian cancer patients--a study of the tumour Bank ovarian cancer (TOC) and ovarian cancer diagnosis consortium (OVCAD).
Ruscito I, Dimitrova D, Vasconcelos I, Gellhaus K, Schwachula T, Bellati F, Zeillinger R, Benedetti-Panici P, Vergote I, Mahner S, Cacsire-Tong D, Concin N, Darb-Esfahani S, Lambrechts S, Sehouli J, Olek S, Braicu EI. Ruscito I, et al. Among authors: schwachula t. Eur J Cancer. 2014 Aug;50(12):2090-8. doi: 10.1016/j.ejca.2014.05.001. Epub 2014 Jun 2. Eur J Cancer. 2014. PMID: 24889916