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Page 1
Decompressive Craniectomy versus Craniotomy for Acute Subdural Hematoma.
Hutchinson PJ, Adams H, Mohan M, Devi BI, Uff C, Hasan S, Mee H, Wilson MH, Gupta DK, Bulters D, Zolnourian A, McMahon CJ, Stovell MG, Al-Tamimi YZ, Tewari MK, Tripathi M, Thomson S, Viaroli E, Belli A, King AT, Helmy AE, Timofeev IS, Pyne S, Shukla DP, Bhat DI, Maas AR, Servadei F, Manley GT, Barton G, Turner C, Menon DK, Gregson B, Kolias AG; British Neurosurgical Trainee Research Collaborative, NIHR Global Health Research Group on Acquired Brain and Spine Injury, and RESCUE-ASDH Trial Collaborators; RESCUE-ASDH Trial Collaborators. Hutchinson PJ, et al. N Engl J Med. 2023 Jun 15;388(24):2219-2229. doi: 10.1056/NEJMoa2214172. Epub 2023 Apr 23. N Engl J Med. 2023. PMID: 37092792 Clinical Trial.
Secondary outcomes included the GOSE rating at 6 months and quality of life as assessed by the EuroQol Group 5-Dimension 5-Level questionnaire (EQ-5D-5L). RESULTS: A total of 228 patients were assigned to the craniotomy group and 222 to the decompressive craniectomy group. …
Secondary outcomes included the GOSE rating at 6 months and quality of life as assessed by the EuroQol Group 5-Dimension 5-Level questionnai …
Generic Health-Related Quality-of-Life Changes after Rhinoplasty: A Prospective Study with Long-Term Results.
Xavier R, Azeredo-Lopes S, Menger DJ, de Carvalho HC, Spratley J. Xavier R, et al. Facial Plast Surg. 2023 Apr;39(2):164-172. doi: 10.1055/a-1932-8563. Epub 2022 Aug 29. Facial Plast Surg. 2023. PMID: 36037858

RESULTS: There was a significant improvement in EQ-5D (p < 0.001), EQ-5D VAS (p = 0.002) and in the SF-36 domains of general health (p < 0.001), energy (p < 0.001), physical functioning (p < 0.001), physical limitation

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RESULTS: There was a significant improvement in EQ-5D (p < 0.001), EQ-5D VAS (p = 0.002) and in the SF-36 dom

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Lumbosacral transitional vertebrae: prevalence in a southern European population and its association with low back pain.
Vinha A, Bártolo J, Lemos C, Cordeiro F, Rodrigues-Pinto R. Vinha A, et al. Eur Spine J. 2022 Dec;31(12):3647-3653. doi: 10.1007/s00586-022-07415-4. Epub 2022 Oct 8. Eur Spine J. 2022. PMID: 36208322

Individuals with LSTV were more likely to report low back pain and have a higher ODI score (OR:0.392, 95% CI:0.192-0.802, p = 0.010), (OR: 1050, 95% CI: 1029-1072, p < 0.01). Castellvi's type IV showed a significantly higher ODI when compared to type II (OR:1059,

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Individuals with LSTV were more likely to report low back pain and have a higher ODI score (OR:0.392, 95% CI:0.192-0.802, p = 0.010), …
UK Medical Cannabis Registry palliative care patients cohort: initial experience and outcomes.
Nimalan D, Kawka M, Erridge S, Ergisi M, Harris M, Salazar O, Ali R, Loupasaki K, Holvey C, Coomber R, Platt M, Rucker JJ, Khan S, Sodergren MH. Nimalan D, et al. J Cannabis Res. 2022 Jan 4;4(1):3. doi: 10.1186/s42238-021-00114-9. J Cannabis Res. 2022. PMID: 34980282 Free PMC article.
Secondary outcomes included the incidence and characteristics of adverse events. Statistical significance was defined by p-value< 0.050. RESULTS: Sixteen patients were included in the analysis, with a mean age of 63.25 years. ...Improvements in patient reported health o …
Secondary outcomes included the incidence and characteristics of adverse events. Statistical significance was defined by p-value< …
An Updated Analysis of Clinical Outcome Measures Across Patients From the UK Medical Cannabis Registry.
Ergisi M, Erridge S, Harris M, Kawka M, Nimalan D, Salazar O, Loupasaki K, Ali R, Holvey C, Coomber R, Usmani A, Sajad M, Beri S, Hoare J, Khan SA, Weatherall MW, Platt M, Rucker JJ, Sodergren MH. Ergisi M, et al. Cannabis Cannabinoid Res. 2023 Jun;8(3):557-566. doi: 10.1089/can.2021.0145. Epub 2022 Jan 24. Cannabis Cannabinoid Res. 2023. PMID: 35073160
Statistical significance was defined as p<0.050. Results: Three hundred twelve patients were included in the final analysis, with a mean age of 44.8. ...Statistically significant improvements were observed in GAD-7, EQ-5D-5L Index, EQ-5D Visual Analog Scal …
Statistical significance was defined as p<0.050. Results: Three hundred twelve patients were included in the final analysis, with …
An initial analysis of the UK Medical Cannabis Registry: Outcomes analysis of first 129 patients.
Erridge S, Salazar O, Kawka M, Holvey C, Coomber R, Usmani A, Sajad M, Beri S, Hoare J, Khan S, Weatherall MW, Platt M, Rucker JJ, Sodergren MH. Erridge S, et al. Neuropsychopharmacol Rep. 2021 Sep;41(3):362-370. doi: 10.1002/npr2.12183. Epub 2021 May 14. Neuropsychopharmacol Rep. 2021. PMID: 33988306 Free PMC article.
Primary outcomes were change in patient-reported outcomes measures (EQ-5D-5L, General Anxiety Disorder-7 (GAD-7) and Single-Item Sleep Quality Scale (SQS)) at 1 and 3 months from baseline. ...Statistically significant improvements in health-related quality of life were dem …
Primary outcomes were change in patient-reported outcomes measures (EQ-5D-5L, General Anxiety Disorder-7 (GAD-7) and Single-Item Slee …
UK Medical Cannabis registry: an analysis of clinical outcomes of medicinal cannabis therapy for chronic pain conditions.
Harris M, Erridge S, Ergisi M, Nimalan D, Kawka M, Salazar O, Ali R, Loupasaki K, Holvey C, Coomber R, Usmani A, Sajad M, Hoare J, Rucker JJ, Platt M, Sodergren MH. Harris M, et al. Expert Rev Clin Pharmacol. 2022 Apr;15(4):473-485. doi: 10.1080/17512433.2022.2017771. Epub 2021 Dec 31. Expert Rev Clin Pharmacol. 2022. PMID: 34937477
Primary outcomes were changes in Brief Pain Inventory short-form (BPI), Short-form McGill Pain Questionnaire-2 (SF-MPQ-2), Visual Analogue Scale-Pain (VAS), General Anxiety Disorder-7 (GAD-7), Sleep Quality Scale (SQS), and EQ-5D-5L, at 1, 3, and 6 months from baseline. St …
Primary outcomes were changes in Brief Pain Inventory short-form (BPI), Short-form McGill Pain Questionnaire-2 (SF-MPQ-2), Visual Analogue S …
UK Medical Cannabis Registry: an analysis of clinical outcomes of medicinal cannabis therapy for generalized anxiety disorder.
Ergisi M, Erridge S, Harris M, Kawka M, Nimalan D, Salazar O, Loupasaki K, Ali R, Holvey C, Coomber R, Platt M, Rucker JJ, Sodergren MH. Ergisi M, et al. Expert Rev Clin Pharmacol. 2022 Apr;15(4):487-495. doi: 10.1080/17512433.2022.2020640. Epub 2022 Jan 18. Expert Rev Clin Pharmacol. 2022. PMID: 34937473
Statistical significance was defined as p<0.050. RESULTS: Sixty-seven patients were treated for generalized anxiety disorder. Statistically significant improvements were observed in GAD-7, EQ-5D-5L Index Value, EQ5D Visual Analog Scale, and SQS scores at 1, 3 and …
Statistical significance was defined as p<0.050. RESULTS: Sixty-seven patients were treated for generalized anxiety disorder. Stat …
Antitumor Activity of Quinazolinone Alkaloids Inspired by Marine Natural Products.
Long S, Resende DISP, Kijjoa A, Silva AMS, Pina A, Fernández-Marcelo T, Vasconcelos MH, Sousa E, Pinto MMM. Long S, et al. Mar Drugs. 2018 Jul 31;16(8):261. doi: 10.3390/md16080261. Mar Drugs. 2018. PMID: 30065225 Free PMC article.
The marine natural product fiscalin B (4c), and antienantiomers (4b, 5b, and 5c) were synthesized via a one-pot approach, while the syn enantiomers (4a, 4d, 5a, and 5d) were synthetized by a multi-step procedure. These strategies used anthranilic acid (i), chiral N-protect …
The marine natural product fiscalin B (4c), and antienantiomers (4b, 5b, and 5c) were synthesized via a one-pot approach, while the syn enan …
Health-related quality of life may improve after transplantation in pancreas-kidney recipients.
Martins LS, Outerelo C, Malheiro J, Fonseca IM, Henriques AC, Dias LS, Rodrigues AS, Cabrita AM, Noronha IL. Martins LS, et al. Clin Transplant. 2015 Mar;29(3):242-51. doi: 10.1111/ctr.12511. Epub 2015 Jan 30. Clin Transplant. 2015. PMID: 25581297

The 60 men and 66 women enrolled had a mean follow-up of five yr; 84.1% with both grafts, 15.9% with one graft functioning. In all domains of EuroQol-5D scores improved after PKT, as well as the visual analogue scale health state (from 38% to 84%, p < 0.001; effe

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The 60 men and 66 women enrolled had a mean follow-up of five yr; 84.1% with both grafts, 15.9% with one graft functioning. In all domains o …
12 results