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1999 1
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2018 1
2021 2
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2023 4
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40 results

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Page 1
The Cytidine N-Acetyltransferase NAT10 Participates in Peripheral Nerve Injury-Induced Neuropathic Pain by Stabilizing SYT9 Expression in Primary Sensory Neurons.
Zhang M, Yang K, Wang QH, Xie L, Liu Q, Wei R, Tao Y, Zheng HL, Lin N, Xu H, Yang L, Wang H, Zhang T, Xue Z, Cao JL, Pan Z. Zhang M, et al. J Neurosci. 2023 Apr 26;43(17):3009-3027. doi: 10.1523/JNEUROSCI.2321-22.2023. Epub 2023 Mar 10. J Neurosci. 2023. PMID: 36898834 Free PMC article.
Knock-down or genetic deletion of NAT10 in the DRG abolishes the gain of ac4C sites in Syt9 mRNA and the augmentation of SYT9 protein, resulting in a marked antinociceptive effect in nerve-injured male mice. Conversely, mimicking NAT10 upregulation in the absence of …
Knock-down or genetic deletion of NAT10 in the DRG abolishes the gain of ac4C sites in Syt9 mRNA and the augmentation of SYT9 …
SYNAPTOTAGMIN-9 IN MOUSE RETINA.
Mesnard CS, Hays CL, Townsend LE, Barta CL, Gurumurthy CB, Thoreson WB. Mesnard CS, et al. bioRxiv [Preprint]. 2024 Mar 16:2023.06.27.546758. doi: 10.1101/2023.06.27.546758. bioRxiv. 2024. PMID: 37425946 Free PMC article. Preprint.
The presence and role of Syt9 in retina is unknown. We found evidence for Syt9 expression throughout the retina and created mice to conditionally eliminate Syt9 in a cre-dependent manner. We crossed Syt9(fl/fl) mice with Rho-iCre, HRGP-Cre, and CMV-cre …
The presence and role of Syt9 in retina is unknown. We found evidence for Syt9 expression throughout the retina and created mi …
The landscape of genetic diseases in Saudi Arabia based on the first 1000 diagnostic panels and exomes.
Monies D, Abouelhoda M, AlSayed M, Alhassnan Z, Alotaibi M, Kayyali H, Al-Owain M, Shah A, Rahbeeni Z, Al-Muhaizea MA, Alzaidan HI, Cupler E, Bohlega S, Faqeih E, Faden M, Alyounes B, Jaroudi D, Goljan E, Elbardisy H, Akilan A, Albar R, Aldhalaan H, Gulab S, Chedrawi A, Al Saud BK, Kurdi W, Makhseed N, Alqasim T, El Khashab HY, Al-Mousa H, Alhashem A, Kanaan I, Algoufi T, Alsaleem K, Basha TA, Al-Murshedi F, Khan S, Al-Kindy A, Alnemer M, Al-Hajjar S, Alyamani S, Aldhekri H, Al-Mehaidib A, Arnaout R, Dabbagh O, Shagrani M, Broering D, Tulbah M, Alqassmi A, Almugbel M, AlQuaiz M, Alsaman A, Al-Thihli K, Sulaiman RA, Al-Dekhail W, Alsaegh A, Bashiri FA, Qari A, Alhomadi S, Alkuraya H, Alsebayel M, Hamad MH, Szonyi L, Abaalkhail F, Al-Mayouf SM, Almojalli H, Alqadi KS, Elsiesy H, Shuaib TM, Seidahmed MZ, Abosoudah I, Akleh H, AlGhonaium A, Alkharfy TM, Al Mutairi F, Eyaid W, Alshanbary A, Sheikh FR, Alsohaibani FI, Alsonbul A, Al Tala S, Balkhy S, Bassiouni R, Alenizi AS, Hussein MH, Hassan S, Khalil M, Tabarki B, Alshahwan S, Oshi A, Sabr Y, Alsaadoun S, Salih MA, Mohamed S, Sultana H, Tamim A, El-Haj M, Alshahrani S, Bubshait DK, Alfadhel M, Faquih T, El-Kalioby M, Subhani S, Shah … See abstract for full author list ➔ Monies D, et al. Hum Genet. 2017 Aug;136(8):921-939. doi: 10.1007/s00439-017-1821-8. Epub 2017 Jun 9. Hum Genet. 2017. PMID: 28600779 Free PMC article.
Finally, we have encountered candidate variants in 75 genes (ABHD6, ACY3, ADGRB2, ADGRG7, AGTPBP1, AHNAK2, AKAP6, ASB3, ATXN1L, C17orf62, CABP1, CCDC186, CCP110, CLSTN2, CNTN3, CNTN5, CTNNA2, CWC22, DMAP1, DMKN, DMXL1, DSCAM, DVL2, ECI1, EP400, EPB41L5, FBXL22, GAP43, GEMIN7, GIT …
Finally, we have encountered candidate variants in 75 genes (ABHD6, ACY3, ADGRB2, ADGRG7, AGTPBP1, AHNAK2, AKAP6, ASB3, ATXN1L, C17orf62, CA …
Synaptotagmin 9 Modulates Spontaneous Neurotransmitter Release in Striatal Neurons by Regulating Substance P Secretion.
Seibert MJ, Evans CS, Stanley KS, Wu Z, Chapman ER. Seibert MJ, et al. J Neurosci. 2023 Mar 1;43(9):1475-1491. doi: 10.1523/JNEUROSCI.1857-22.2023. Epub 2023 Feb 2. J Neurosci. 2023. PMID: 36732068 Free PMC article.
Loss of SYT9 impaired SP release, causing the observed decrease in mini frequency. ...This demonstrates a novel role for SYT9 in neurons and uncovers a new field of study into neuromodulation by SYT9, a protein that is widely expressed in the brain....
Loss of SYT9 impaired SP release, causing the observed decrease in mini frequency. ...This demonstrates a novel role for SYT9 …
Genetic ablation of synaptotagmin-9 alters tomosyn-1 function to increase insulin secretion from pancreatic β-cells improving glucose clearance.
Rahman MM, Pathak A, Schueler KL, Alsharif H, Michl A, Alexander J, Kim JA, Bhatnagar S. Rahman MM, et al. FASEB J. 2023 Aug;37(8):e23075. doi: 10.1096/fj.202300291RR. FASEB J. 2023. PMID: 37432648
These outcomes differ from the previously published work that identified Syt9 has either a positive or no effect of Syt9 on insulin secretion. Future work using beta-cell-specific deletion of Syt9 mice is key for establishing the role of Syt9 in insuli …
These outcomes differ from the previously published work that identified Syt9 has either a positive or no effect of Syt9 on in …
The Zika virus infection remodels the expression of the synaptotagmin-9 secretory protein.
Leiva S, Cantoia A, Fabbri C, Bugnon Valdano M, Luppo V, Morales MA, Rosano G, Gardiol D. Leiva S, et al. Biol Chem. 2023 Sep 8;405(3):189-201. doi: 10.1515/hsz-2023-0165. Print 2024 Mar 25. Biol Chem. 2023. PMID: 37677740
We confirmed the effect of NS1 on SYT9 levels by transfection models while also detecting a significant subcellular redistribution of SYT9. We found that ZIKV prM-Env proteins, required for the viral particle release, also increased SYT9 levels and changed it …
We confirmed the effect of NS1 on SYT9 levels by transfection models while also detecting a significant subcellular redistribution of …
Pharmacological Bypass of Cockayne Syndrome B Function in Neuronal Differentiation.
Wang Y, Jones-Tabah J, Chakravarty P, Stewart A, Muotri A, Laposa RR, Svejstrup JQ. Wang Y, et al. Cell Rep. 2016 Mar 22;14(11):2554-61. doi: 10.1016/j.celrep.2016.02.051. Epub 2016 Mar 10. Cell Rep. 2016. PMID: 26972010 Free PMC article.
Mutation of Cockayne syndrome B (CSB) affects neuronal gene expression and differentiation, so we attempted to bypass its function by expressing downstream target genes. Intriguingly, ectopic expression of Synaptotagmin 9 (SYT9), a key component of the machinery controllin …
Mutation of Cockayne syndrome B (CSB) affects neuronal gene expression and differentiation, so we attempted to bypass its function by expres …
A genetic variant in a homocysteine metabolic gene that increases the risk of congenital cardiac septal defects in Han Chinese populations.
Xie HH, Li J, Li PQ, Zhang AA, Li Y, Wang YZ, Xie DX, Xie XD. Xie HH, et al. IUBMB Life. 2017 Sep;69(9):700-705. doi: 10.1002/iub.1651. IUBMB Life. 2017. PMID: 28834160 Free article.
The intronic variant rs11041321 of the SYT9 gene was associated with an increased risk of developing CCSDs in both the separate and combined case-controlled studies. ...The intronic SYT9 variant rs11041321, which exhibits a significant genome-wide association with c …
The intronic variant rs11041321 of the SYT9 gene was associated with an increased risk of developing CCSDs in both the separate and c …
Comprehensive analysis on the expression profile and prognostic values of Synaptotagmins (SYTs) family members and their methylation levels in gastric cancer.
Yang MF, Long XX, Hu HS, Bin YL, Chen XM, Wu BH, Peng QZ, Wang LS, Yao J, Li DF. Yang MF, et al. Bioengineered. 2021 Dec;12(1):3550-3565. doi: 10.1080/21655979.2021.1951059. Bioengineered. 2021. PMID: 34229539 Free PMC article.
Both the over-expression of SYT4, SYT9 and SYT14 and their hypomethylation levels contributed to an unsatisfactory overall survival (OS) and progression-free survival (PFS) in GC. ...Collectively, our current finding suggested that SYT4, SYT9 and SYT14 might be pote …
Both the over-expression of SYT4, SYT9 and SYT14 and their hypomethylation levels contributed to an unsatisfactory overall survival ( …
Screening of Hydrocarbon-Stapled Peptides for Inhibition of Calcium-Triggered Exocytosis.
Lai Y, Tuvim MJ, Leitz J, Peters J, Pfuetzner RA, Esquivies L, Zhou Q, Czako B, Cross JB, Jones P, Dickey BF, Brunger AT. Lai Y, et al. Front Pharmacol. 2022 Jun 17;13:891041. doi: 10.3389/fphar.2022.891041. eCollection 2022. Front Pharmacol. 2022. PMID: 35814209 Free PMC article.
The interacting residues of the primary interface are conserved across different species for synaptotagmins (Syt1, Syt2, Syt9), SNAP-25, and syntaxin-1A homologs involved in fast synchronous release. ...
The interacting residues of the primary interface are conserved across different species for synaptotagmins (Syt1, Syt2, Syt9), SNAP- …
40 results