Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 1
2009 1
2010 2
2011 2
2013 1
2016 1
2017 1
2018 1
2021 1
2022 4
2023 1
2024 1

Text availability

Article attribute

Article type

Publication date

Search Results

16 results

Results by year

Filters applied: . Clear all
Page 1
Transcriptional Regulation of the Synaptic Vesicle Protein Synaptogyrin-3 (SYNGR3) Gene: The Effects of NURR1 on Its Expression.
Li L, Ho PW, Liu H, Pang SY, Chang EE, Choi ZY, Malki Y, Kung MH, Ramsden DB, Ho SL. Li L, et al. Int J Mol Sci. 2022 Mar 26;23(7):3646. doi: 10.3390/ijms23073646. Int J Mol Sci. 2022. PMID: 35409005 Free PMC article.
SYNGR3 interacts with the dopamine transporter (DAT) to facilitate dopamine (DA) uptake and synaptic DA turnover in dopaminergic transmission. Perturbed SYNGR3 expression is observed in Parkinson's disease (PD). The regulatory elements which affect SYNGR3 exp
SYNGR3 interacts with the dopamine transporter (DAT) to facilitate dopamine (DA) uptake and synaptic DA turnover in dopaminergic tran
Tumor Cell Extrinsic Synaptogyrin 3 Expression as a Diagnostic and Prognostic Biomarker in Head and Neck Cancer.
Murphy RM, Tasoulas J, Porrello A, Carper MB, Tsai YH, Coffey AR, Kumar S, Zeng PY, Schrank TP, Midkiff BR, Cohen S, Salazar AH, Hayward MC, Hayes DN, Olshan A, Gupta GP, Nichols AC, Yarbrough WG, Pecot CV, Amelio AL. Murphy RM, et al. Cancer Res Commun. 2022 Sep;2(9):987-1004. doi: 10.1158/2767-9764.crc-21-0135. Epub 2022 Sep 15. Cancer Res Commun. 2022. PMID: 36148399 Free PMC article.
SYNGR3-high HNSC patients have significantly better prognosis with five-year OS and DSS rates of 60% and 71%, respectively. ...SYNGR3 expression in T and B cells is associated with HPV status and enhanced survival outcomes of HNSC patients....
SYNGR3-high HNSC patients have significantly better prognosis with five-year OS and DSS rates of 60% and 71%, respectively. ...SYN
In vivo overexpression of synaptogyrin-3 promotes striatal synaptic dopamine uptake in LRRK2R1441G  mutant mouse model of Parkinson's disease.
Ho PW, Li L, Liu HF, Choi ZY, Chang EES, Pang SY, Malki Y, Leung CT, Kung MH, Ramsden DB, Ho SL. Ho PW, et al. Brain Behav. 2023 Feb;13(2):e2886. doi: 10.1002/brb3.2886. Epub 2023 Jan 9. Brain Behav. 2023. PMID: 36624932 Free PMC article.
Previous in vitro studies demonstrated interaction between SYNGR3 and DAT. Reduced SYNGR3 expression was observed in human PD brains with unclear reasons. ...Our preliminary behavioral test showed improved innate behavior after SYNGR3 overexpression in LRRK2 …
Previous in vitro studies demonstrated interaction between SYNGR3 and DAT. Reduced SYNGR3 expression was observed in human PD …
The interaction of Synapsin 2a and Synaptogyrin-3 regulates fear extinction in mice.
Shen XY, Zhang J, Huang HZ, Li SD, Zhou L, Wu SP, Tang C, Huang X, Liu ZQ, Guo ZY, Li X, Man HY, Lu YM, Zhu LQ, Liu D. Shen XY, et al. J Clin Invest. 2024 Jan 4;134(4):e172802. doi: 10.1172/JCI172802. J Clin Invest. 2024. PMID: 38175724 Free PMC article.
Molecular docking revealed that ritonavir, an FDA-approved HIV drug, could disrupt Syn2a-Syngr3 binding and rescue fear extinction behavior in Syn2a-elevated mice. In summary, the aberrant elevation of Syn2a expression and its interaction with Syngr3 at the presynap …
Molecular docking revealed that ritonavir, an FDA-approved HIV drug, could disrupt Syn2a-Syngr3 binding and rescue fear extinction be …
Identifying the hub gene and immune infiltration of Parkinson's disease using bioinformatical methods.
Liu SH, Wang YL, Jiang SM, Wan XJ, Yan JH, Liu CF. Liu SH, et al. Brain Res. 2022 Jun 15;1785:147879. doi: 10.1016/j.brainres.2022.147879. Epub 2022 Mar 10. Brain Res. 2022. PMID: 35278479
Gene Expression Omnibus (GEO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses suggested that these genes were markedly enriched in the pathway of synthesis and transport of neurons. Three candidate genes (SLC18A2, CALB1, and SYNGR3) were further identified in P …
Gene Expression Omnibus (GEO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses suggested that these genes were markedly enriched …
Characterization of the human synaptogyrin gene family.
Kedra D, Pan HQ, Seroussi E, Fransson I, Guilbaud C, Collins JE, Dunham I, Blennow E, Roe BA, Piehl F, Dumanski JP. Kedra D, et al. Hum Genet. 1998 Aug;103(2):131-41. doi: 10.1007/s004390050795. Hum Genet. 1998. PMID: 9760194
We also characterized two additional members of this novel synaptogyrin gene family in human (SYNGR2 and SYNGR3), and one in mouse (Syngr2). The human SYNGR2 gene transcript of 1.6 kb is expressed at high levels in all tissues, except brain. The 2.2-kb SYNGR3 transc …
We also characterized two additional members of this novel synaptogyrin gene family in human (SYNGR2 and SYNGR3), and one in mouse (S …
Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation.
Largo-Barrientos P, Apóstolo N, Creemers E, Callaerts-Vegh Z, Swerts J, Davies C, McInnes J, Wierda K, De Strooper B, Spires-Jones T, de Wit J, Uytterhoeven V, Verstreken P. Largo-Barrientos P, et al. Neuron. 2021 Mar 3;109(5):767-777.e5. doi: 10.1016/j.neuron.2020.12.016. Epub 2021 Jan 19. Neuron. 2021. PMID: 33472038 Free PMC article.
Age-related changes in gene expression are accelerated in Alzheimer's disease.
Saetre P, Jazin E, Emilsson L. Saetre P, et al. Synapse. 2011 Sep;65(9):971-4. doi: 10.1002/syn.20933. Epub 2011 Apr 11. Synapse. 2011. PMID: 21425351
Our results demonstrate that the age-related changes in gene expression are manifested earlier in AD. Furthermore, five of the genes (ITPKB, RGS4, RAB3A, STMN1, SYNGR3) have in common an involvement in neuronal calcium dependent signaling, a cellular process previously rel …
Our results demonstrate that the age-related changes in gene expression are manifested earlier in AD. Furthermore, five of the genes (ITPKB, …
Harnessing the trophic and modulatory potential of statins in a dopaminergic cell line.
Schmitt M, Dehay B, Bezard E, Garcia-Ladona FJ. Schmitt M, et al. Synapse. 2016 Mar;70(3):71-86. doi: 10.1002/syn.21881. Epub 2016 Jan 6. Synapse. 2016. PMID: 26695835
Statins increased the levels of presynaptic dopaminergic biomarkers such as vesicular monoamine transporter 2 (VMAT2), synaptic vesicle glycoproteins 2A and 2C (SV2C), and synaptogyrin-3 (SYNGR3). Gene expression analysis confirmed a rapid statin-induced up-regulation of V …
Statins increased the levels of presynaptic dopaminergic biomarkers such as vesicular monoamine transporter 2 (VMAT2), synaptic vesicle glyc …
Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau.
McInnes J, Wierda K, Snellinx A, Bounti L, Wang YC, Stancu IC, Apóstolo N, Gevaert K, Dewachter I, Spires-Jones TL, De Strooper B, De Wit J, Zhou L, Verstreken P. McInnes J, et al. Neuron. 2018 Feb 21;97(4):823-835.e8. doi: 10.1016/j.neuron.2018.01.022. Epub 2018 Feb 1. Neuron. 2018. PMID: 29398363 Free article.
16 results