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Mol Cell. 2012 Jan 27;45(2):210-21. doi: 10.1016/j.molcel.2011.12.026.

SUMO-specific protease 1 is critical for early lymphoid development through regulation of STAT5 activation.

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  • 1Department of Cardiology, Center for Inflammation and Cancer, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.


Small ubiquitin-like modifier (SUMO) modification has emerged as an important regulatory mechanism during embryonic development. However, it is not known whether SUMOylation plays a role in the development of the immune system. Here, we show that SUMO-specific protease 1 (SENP1) is essential for the development of early T and B cells. STAT5, a key regulator of lymphoid development, is modified by SUMO-2 and is specifically regulated by SENP1. In the absence of SENP1, SUMO-2 modified STAT5 accumulates in early lymphoid precursors, resulting in a block in its acetylation and subsequent signaling. These results demonstrate a crucial role of SENP1 in the regulation of STAT5 activation during early lymphoid development.

Copyright © 2012 Elsevier Inc. All rights reserved.

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