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Year Number of Results
1993 2
1994 1
1995 4
1996 5
1997 8
1998 7
1999 13
2000 15
2001 7
2002 12
2003 10
2004 15
2005 17
2006 19
2007 26
2008 22
2009 29
2010 17
2011 31
2012 30
2013 19
2014 36
2015 30
2016 15
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2018 29
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2024 7

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507 results

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Page 1
Duplication of SOX3 in an SRY-negative 46,XX male with prostatic utricle: case report and literature review.
Wei J, Liu C, Zhang M, Liu S, Fu J, Lin P. Wei J, et al. BMC Med Genomics. 2022 Sep 5;15(1):188. doi: 10.1186/s12920-022-01347-0. BMC Med Genomics. 2022. PMID: 36064700 Free PMC article. Review.
Whole-genome analysis showed the boy has a 1.4-Mb duplication in the Xq27.1q27.2 region (arr[hg19]Xq27.1q27.2:139585794-140996652) involving SOX3. No SOX3 duplication was observed in the parents, who had a normal phenotype. CONCLUSIONS: We report the first case of a …
Whole-genome analysis showed the boy has a 1.4-Mb duplication in the Xq27.1q27.2 region (arr[hg19]Xq27.1q27.2:139585794-140996652) involving …
Regulation of the SOX3 gene expression by retinoid receptors.
Nikčević G, Kovačević-Grujičić N, Mojsin M, Krstić A, Savić T, Stevanović M. Nikčević G, et al. Physiol Res. 2011;60(Suppl 1):S83-91. doi: 10.33549/physiolres.932184. Epub 2011 Jul 19. Physiol Res. 2011. PMID: 21777018 Free article. Review.
Sox3/SOX3 gene is considered to be one of the earliest neural markers in vertebrates. Despite the mounting evidence that Sox3/SOX3 is one of the key players in the development of the nervous system, limited data are available regarding the transcriptio …
Sox3/SOX3 gene is considered to be one of the earliest neural markers in vertebrates. Despite the mounting evidence that So …
SOX3 promotes generation of committed spermatogonia in postnatal mouse testes.
McAninch D, Mäkelä JA, La HM, Hughes JN, Lovell-Badge R, Hobbs RM, Thomas PQ. McAninch D, et al. Sci Rep. 2020 Apr 21;10(1):6751. doi: 10.1038/s41598-020-63290-3. Sci Rep. 2020. PMID: 32317665 Free PMC article.
Additionally, we use a Sox3 null mouse model to define a potential role for this factor in progenitor cell function. ...Critically, using chromatin immunoprecipitation, we demonstrate that SOX3 binds to a highly conserved region in the Ngn3 promoter region in vivo, …
Additionally, we use a Sox3 null mouse model to define a potential role for this factor in progenitor cell function. ...Critically, u …
A complex structural variant near SOX3 causes X-linked split-hand/foot malformation.
de Boer E, Marcelis C, Neveling K, van Beusekom E, Hoischen A, Klein WM, de Leeuw N, Mantere T, Melo US, van Reeuwijk J, Smeets D, Spielmann M, Kleefstra T, van Bokhoven H, Vissers LELM. de Boer E, et al. HGG Adv. 2023 Apr 25;4(3):100200. doi: 10.1016/j.xhgg.2023.100200. eCollection 2023 Jul 13. HGG Adv. 2023. PMID: 37216008 Free PMC article.
In silico analysis suggested that the SV disrupts the regulatory framework on the X chromosome and may lead to SOX3 misexpression. We hypothesize that SOX3 dysregulation in the developing limb disturbed the fine balance between morphogens required for maintaining AE …
In silico analysis suggested that the SV disrupts the regulatory framework on the X chromosome and may lead to SOX3 misexpression. We …
Xq27.1 Duplication Encompassing SOX3: Variable Phenotype and Smallest Duplication Associated with Hypopituitarism to Date - A Large Case Series of Unrelated Patients and a Literature Review.
Arya VB, Chawla G, Nambisan AKR, Muhi-Iddin N, Vamvakiti E, Ajzensztejn M, Hulse T, Ferreira Pinto C, Lahiri N, Bint S, Buchanan CR, Kapoor RR. Arya VB, et al. Horm Res Paediatr. 2019;92(6):382-389. doi: 10.1159/000503784. Epub 2019 Nov 1. Horm Res Paediatr. 2019. PMID: 31678974 Review.
BACKGROUND: Xq27.1 duplication encompassing SOX3 has been implicated in the aetiology of X-linked hypopituitarism associated with intellectual disability and neural tube defects. We describe the largest case series to date of 5 unrelated patients with SOX3 duplicati …
BACKGROUND: Xq27.1 duplication encompassing SOX3 has been implicated in the aetiology of X-linked hypopituitarism associated with int …
SOX3 can promote the malignant behavior of glioblastoma cells.
Marjanovic Vicentic J, Drakulic D, Garcia I, Vukovic V, Aldaz P, Puskas N, Nikolic I, Tasic G, Raicevic S, Garros-Regulez L, Sampron N, Atkinson MJ, Anastasov N, Matheu A, Stevanovic M. Marjanovic Vicentic J, et al. Cell Oncol (Dordr). 2019 Feb;42(1):41-54. doi: 10.1007/s13402-018-0405-5. Epub 2018 Sep 12. Cell Oncol (Dordr). 2019. PMID: 30209685
However, little is known about its role in glioblastoma. Thus, the aim of this work was to elucidate the role of SOX3 in glioblastoma. METHODS: SOX3 expression was assessed using real-time quantitative PCR (RT-qPCR), Western blotting and immunohistochemistry. ...CON …
However, little is known about its role in glioblastoma. Thus, the aim of this work was to elucidate the role of SOX3 in glioblastoma …
Role of Sox3 in Estradiol-Induced Sex Reversal in Pelodiscus sinensis.
Zhou T, Cao J, Chen G, Wang Y, Zou G, Liang H. Zhou T, et al. Int J Mol Sci. 2023 Dec 23;25(1):248. doi: 10.3390/ijms25010248. Int J Mol Sci. 2023. PMID: 38203425 Free PMC article.
During embryonic development, Sox3 was highly expressed at the initiation of ovarian differentiation. ...These findings suggest that Sox3 may play a certain promoting effect during E2-induced sex reversal in P. sinensis....
During embryonic development, Sox3 was highly expressed at the initiation of ovarian differentiation. ...These findings suggest that …
Transcription factor SOX3 upregulated pro-apoptotic genes expression in human breast cancer.
Silva FHS, Underwood A, Almeida CP, Ribeiro TS, Souza-Fagundes EM, Martins AS, Eliezeck M, Guatimosim S, Andrade LO, Rezende L, Gomes HW, Oliveira CA, Rodrigues RC, Borges IT, Cassali GD, Ferreira E, Del Puerto HL. Silva FHS, et al. Med Oncol. 2022 Sep 29;39(12):212. doi: 10.1007/s12032-022-01758-0. Med Oncol. 2022. PMID: 36175695
BACKGROUND: Sex-determining region Y-box 3 (SOX3) protein, a SOX transcriptions factors group, has been identified as a key regulator in several diseases, including cancer. ...Further studies are necessary to understand how SOX3 protein regulates the promoter region …
BACKGROUND: Sex-determining region Y-box 3 (SOX3) protein, a SOX transcriptions factors group, has been identified as a key regulator …
Characterization of the transcription factor Sox3 regulating the gonadal development of pearlscale angelfish (Centropyge vrolikii).
Feng Y, Zhong ZW, Xu Y, Zhang ZY, Ao LL, Yang Z, Wang YL, Jiang YH. Feng Y, et al. Fish Physiol Biochem. 2022 Oct;48(5):1193-1207. doi: 10.1007/s10695-022-01110-3. Epub 2022 Aug 13. Fish Physiol Biochem. 2022. PMID: 35963922
Nevertheless, the exact expression pattern of this gene in fish is still unknown. Here, we identified the Sox3 gene of Centropyge vrolikii, namely, Cv-Sox3. The Cv-Sox3 mRNA expression in the ovary and testis was detected by reverse transcription-polymerase c …
Nevertheless, the exact expression pattern of this gene in fish is still unknown. Here, we identified the Sox3 gene of Centropyge vro …
Studies of mice deleted for Sox3 and uc482: relevance to X-linked hypoparathyroidism.
Gaynor KU, Grigorieva IV, Mirczuk SM, Piret S, Kooblall KG, Stevenson M, Rizzoti K, Bowl MR, Nesbit MA, Christie PT, Fraser WD, Hough T, Whyte MP, Lovell-Badge R, Thakker R. Gaynor KU, et al. Endocr Connect. 2020 Jan 1;9(2):173-86. doi: 10.1530/EC-19-0478. Online ahead of print. Endocr Connect. 2020. PMID: 31961795 Free PMC article.
SOX3 expression was similar in all individuals, indicating that the spatiotemporal effect of the interstitial deletion-insertion on SOX3 expression postulated to occur in developing parathyroids did not manifest in lymphoblastoids. Expression of SNTG2, which is dupl …
SOX3 expression was similar in all individuals, indicating that the spatiotemporal effect of the interstitial deletion-insertion on …
507 results