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192 results

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Blockage of autophagosome-lysosome fusion through SNAP29 O-GlcNAcylation promotes apoptosis via ROS production.
Pellegrini FR, De Martino S, Fianco G, Ventura I, Valente D, Fiore M, Trisciuoglio D, Degrassi F. Pellegrini FR, et al. Autophagy. 2023 Jul;19(7):2078-2093. doi: 10.1080/15548627.2023.2170962. Epub 2023 Feb 10. Autophagy. 2023. PMID: 36704963 Free PMC article.
Accordingly, SM15 was found to enhance SNAP29 O-GlcNAcylation and, thereby, inhibit the formation of the SNARE fusion complex. ...Consequently, modulation of SNAP29 activity may represent a new opportunity for therapeutic intervention in cancer and other autophagy-a …
Accordingly, SM15 was found to enhance SNAP29 O-GlcNAcylation and, thereby, inhibit the formation of the SNARE fusion complex. ...Con …
Acetylation in the regulation of autophagy.
Xu Y, Wan W. Xu Y, et al. Autophagy. 2023 Feb;19(2):379-387. doi: 10.1080/15548627.2022.2062112. Epub 2022 Apr 18. Autophagy. 2023. PMID: 35435793 Free PMC article. Review.
Here, we review the current knowledge on acetylation of autophagy proteins and their regulations and functions in the autophagy pathway with focus on recent findings.Abbreviations : ACAT1: acetyl-CoA acetyltransferase 1; ACSS2: acyl-CoA synthetase short chain family member 2; AMP …
Here, we review the current knowledge on acetylation of autophagy proteins and their regulations and functions in the autophagy pathway with …
siRNA screening reveals that SNAP29 contributes to exosome release.
Hessvik NP, Sagini K, Romero S, Ramirez-Garrastacho M, Rodriguez M, Tutturen AEV, Kvalvaag A, Stang E, Brech A, Sandvig K, Llorente A. Hessvik NP, et al. Cell Mol Life Sci. 2023 Jun 7;80(7):177. doi: 10.1007/s00018-023-04822-8. Cell Mol Life Sci. 2023. PMID: 37285022 Free PMC article.
These results suggest that SNAP29 depletion mainly affects the secretion of exosomes. To investigate how SNAP29 affects exosome release, we used microscopy to study the distribution of MBVs using CD63 labelling and CD63-pHluorin to detect fusion events of MVBs with …
These results suggest that SNAP29 depletion mainly affects the secretion of exosomes. To investigate how SNAP29 affects exosom …
The ORF7a protein of SARS-CoV-2 initiates autophagy and limits autophagosome-lysosome fusion via degradation of SNAP29 to promote virus replication.
Hou P, Wang X, Wang H, Wang T, Yu Z, Xu C, Zhao Y, Wang W, Zhao Y, Chu F, Chang H, Zhu H, Lu J, Zhang F, Liang X, Li X, Wang S, Gao Y, He H. Hou P, et al. Autophagy. 2023 Feb;19(2):551-569. doi: 10.1080/15548627.2022.2084686. Epub 2022 Jun 19. Autophagy. 2023. PMID: 35670302 Free PMC article.
Mechanistically, the ORF7a protein initiates autophagy via the AKT-MTOR-ULK1-mediated pathway, but ORF7a limits the progression of autophagic flux by activating CASP3 (caspase 3) to cleave the SNAP29 protein at aspartic acid residue 30 (D30), ultimately impairing complete …
Mechanistically, the ORF7a protein initiates autophagy via the AKT-MTOR-ULK1-mediated pathway, but ORF7a limits the progression of autophagi …
Snapshots from within the cell: Novel trafficking and non trafficking functions of Snap29 during tissue morphogenesis.
Smeele PH, Vaccari T. Smeele PH, et al. Semin Cell Dev Biol. 2023 Jan 15;133:42-52. doi: 10.1016/j.semcdb.2022.02.024. Epub 2022 Mar 4. Semin Cell Dev Biol. 2023. PMID: 35256275 Free article. Review.
In this review, we first summarize established functions of Snap29 and then we focus on novel ones in the context of autophagy, Golgi trafficking and vesicle fusion at the plasma membrane, as well as on non-trafficking activities of Snap29. We further describe emerg …
In this review, we first summarize established functions of Snap29 and then we focus on novel ones in the context of autophagy, Golgi …
Snap29 Is Dispensable for Self-Renewal Maintenance but Required for Proper Differentiation of Mouse Embryonic Stem Cells.
Jia Y, Guo Z, Zhu J, Qin G, Sun W, Yin Y, Wang H, Guo R. Jia Y, et al. Int J Mol Sci. 2023 Jan 1;24(1):750. doi: 10.3390/ijms24010750. Int J Mol Sci. 2023. PMID: 36614195 Free PMC article.
However, the function of Snap29 in the self-renewal and differentiation of ESCs remains elusive. ...However, Snap29 deficiency enhances the differentiation of ESCs into cardiomyocytes, as indicated by heart-like beating cells. ...
However, the function of Snap29 in the self-renewal and differentiation of ESCs remains elusive. ...However, Snap29 deficiency …
How to use a multipurpose SNARE: The emerging role of Snap29 in cellular health.
Mastrodonato V, Morelli E, Vaccari T. Mastrodonato V, et al. Cell Stress. 2018 Mar 22;2(4):72-81. doi: 10.15698/cst2018.04.130. Cell Stress. 2018. PMID: 31225470 Free PMC article. Review.
We also discuss Snap29 role in synaptic transmission and in cell division, which might extend the repertoire of SNARE-mediated functions. Finally, we present evidence connecting Snap29 to human disease, highlighting the importance of Snap29 function in tissue …
We also discuss Snap29 role in synaptic transmission and in cell division, which might extend the repertoire of SNARE-mediated functi …
New insights regarding SNARE proteins in autophagosome-lysosome fusion.
Tian X, Teng J, Chen J. Tian X, et al. Autophagy. 2021 Oct;17(10):2680-2688. doi: 10.1080/15548627.2020.1823124. Epub 2020 Sep 24. Autophagy. 2021. PMID: 32924745 Free PMC article. Review.
Of the SNAREs, autophagosome-localized Q-SNAREs, such as STX17 and SNAP29, and lysosome-localized R-SNAREs, such as VAMP8 or VAMP7, have been reported to be involved. ...A better understanding of the functions of SNAREs will shed light on the molecular mechanisms of autoph …
Of the SNAREs, autophagosome-localized Q-SNAREs, such as STX17 and SNAP29, and lysosome-localized R-SNAREs, such as VAMP8 or VAMP7, h …
Snap29 mutant mice recapitulate neurological and ophthalmological abnormalities associated with 22q11 and CEDNIK syndrome.
Keser V, Lachance JB, Alam SS, Lim Y, Scarlata E, Kaur A, Zhang TF, Lv S, Lachapelle P, O'Flaherty C, Golden JA, Jerome-Majewska LA. Keser V, et al. Commun Biol. 2019 Oct 11;2:375. doi: 10.1038/s42003-019-0601-5. eCollection 2019. Commun Biol. 2019. PMID: 31633066 Free PMC article.
SNAP29 maps to the 22q11.2 region and is deleted in 90% of patients with 22q11.2 deletion syndrome (22q11.2DS). ...Our work also reveals an unanticipated requirement for Snap29 in male fertility and supports contribution of hemizygosity for SNAP29 to the phen …
SNAP29 maps to the 22q11.2 region and is deleted in 90% of patients with 22q11.2 deletion syndrome (22q11.2DS). ...Our work also reve …
RUNDC1 inhibits autolysosome formation and survival of zebrafish via clasping ATG14-STX17-SNAP29 complex.
Zhang R, Yang Y, He C, Zhang X, Torraca V, Wang S, Liu N, Yang J, Liu S, Yuan J, Gou D, Li S, Dong X, Xie Y, He J, Bai H, Hu M, Liao Z, Huang Y, Lyu H, Xiao S, Guo D, Ali DW, Michalak M, Ma C, Chen XZ, Tang J, Zhou C. Zhang R, et al. Cell Death Differ. 2023 Oct;30(10):2231-2248. doi: 10.1038/s41418-023-01215-z. Epub 2023 Sep 8. Cell Death Differ. 2023. PMID: 37684417
Moreover, RUNDC1 clasps the ATG14-STX17-SNAP29 complex via stimulating ATG14 homo-oligomerization to inhibit ATG14 dissociation. This also prevents VAMP8 from binding to STX17-SNAP29. We further identified that phosphorylation of RUNDC1 Ser(379) is crucial to inhibi …
Moreover, RUNDC1 clasps the ATG14-STX17-SNAP29 complex via stimulating ATG14 homo-oligomerization to inhibit ATG14 dissociation. This …
192 results