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Nucleotide Sugar Transporter SLC35 Family Structure and Function.
Hadley B, Litfin T, Day CJ, Haselhorst T, Zhou Y, Tiralongo J. Hadley B, et al. Comput Struct Biotechnol J. 2019 Aug 7;17:1123-1134. doi: 10.1016/j.csbj.2019.08.002. eCollection 2019. Comput Struct Biotechnol J. 2019. PMID: 31462968 Free PMC article. Review.
We also report on the recently described first crystal structure of an NST, the SLC35D2 homolog Vrg-4 from yeast. Using this crystal structure, we have generated a new model of SLC35A1, (CMP-sialic acid transporter, CST), with structural and mechanistic predictions based o …
We also report on the recently described first crystal structure of an NST, the SLC35D2 homolog Vrg-4 from yeast. Using this crystal …
Identification and characterization of human Golgi nucleotide sugar transporter SLC35D2, a novel member of the SLC35 nucleotide sugar transporter family.
Ishida N, Kuba T, Aoki K, Miyatake S, Kawakita M, Sanai Y. Ishida N, et al. Genomics. 2005 Jan;85(1):106-16. doi: 10.1016/j.ygeno.2004.09.010. Genomics. 2005. PMID: 15607426
We report the molecular cloning of SLC35D2, a novel member of the SLC35 nucleotide sugar transporter family. The gene SLC35D2 maps to chromosome 9q22.33. SLC35D2 cDNA codes for a hydrophobic protein consisting of 337 amino acid residues with 10 putative trans …
We report the molecular cloning of SLC35D2, a novel member of the SLC35 nucleotide sugar transporter family. The gene SLC35D2 …
Integrated analysis of potential gene crosstalk between non-alcoholic fatty liver disease and diabetic nephropathy.
Yan Q, Zhao Z, Liu D, Li J, Pan S, Duan J, Dong J, Liu Z. Yan Q, et al. Front Endocrinol (Lausanne). 2022 Oct 25;13:1032814. doi: 10.3389/fendo.2022.1032814. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 36387855 Free PMC article.
Ten optimal crosstalk genes were selected by LASSO regression and Boruta algorithm, including CD36, WIPI1, CBX7, FCN1, SLC35D2, CP, ZDHHC3, PTPN3, LPL, and SPP1. Among these genes, LPL and SPP1 were the most significant according to NAFLD-transcription factor network. ...
Ten optimal crosstalk genes were selected by LASSO regression and Boruta algorithm, including CD36, WIPI1, CBX7, FCN1, SLC35D2, CP, Z …
Sequestration of host metabolism by an intracellular pathogen.
Gehre L, Gorgette O, Perrinet S, Prevost MC, Ducatez M, Giebel AM, Nelson DE, Ball SG, Subtil A. Gehre L, et al. Elife. 2016 Mar 16;5:e12552. doi: 10.7554/eLife.12552. Elife. 2016. PMID: 26981769 Free PMC article.
Our data bring strong support to the following scenario: bacteria co-opt the host transporter SLC35D2 to import UDP-glucose into the vacuole, where it serves as substrate for de novo glycogen synthesis, through a remarkable adaptation of the bacterial glycogen synthase. .. …
Our data bring strong support to the following scenario: bacteria co-opt the host transporter SLC35D2 to import UDP-glucose into the …
Genetic haplotypes associated with immune response to Leishmania infantum infection in dogs.
Álvarez L, Marín-García PJ, Llobat L. Álvarez L, et al. Vet Res Commun. 2023 Sep;47(3):1675-1685. doi: 10.1007/s11259-023-10123-z. Epub 2023 Apr 14. Vet Res Commun. 2023. PMID: 37059873
Specifically, haplotypes in IL12RB1, IL6R, CIITA, THEMIS, NOXA1, HEY2, RAB38, SLC35D2, SLC28A3, RASEF and DAPK1 genes are associated with serum levels of IFN-gamma, IL-2, IL-8, and IL-18. ...
Specifically, haplotypes in IL12RB1, IL6R, CIITA, THEMIS, NOXA1, HEY2, RAB38, SLC35D2, SLC28A3, RASEF and DAPK1 genes are associated …
Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study.
Lee Y, Yoon KA, Joo J, Lee D, Bae K, Han JY, Lee JS. Lee Y, et al. Carcinogenesis. 2013 Feb;34(2):307-13. doi: 10.1093/carcin/bgs356. Epub 2012 Nov 8. Carcinogenesis. 2013. PMID: 23144319
These SNPs were located in the genomic regions of the FAM154A, ANKS1A, DLST, THSD7B, NCOA2, CDH8, SLC35D2, NALCN and EGF genes. The most significant SNP, rs1571228 (9p22.1:FAM154A), was significantly associated with overall survival in dominant model [AG+GG to AA, hazard r …
These SNPs were located in the genomic regions of the FAM154A, ANKS1A, DLST, THSD7B, NCOA2, CDH8, SLC35D2, NALCN and EGF genes. The m …
Understanding of decreased sialylation of Fc-fusion protein in hyperosmotic recombinant Chinese hamster ovary cell culture: N-glycosylation gene expression and N-linked glycan antennary profile.
Lee JH, Jeong YR, Kim YG, Lee GM. Lee JH, et al. Biotechnol Bioeng. 2017 Aug;114(8):1721-1732. doi: 10.1002/bit.26284. Epub 2017 Mar 30. Biotechnol Bioeng. 2017. PMID: 28266015
After 3 days of hyperosmotic culture, nine genes (ugp, slc35a3, slc35d2, gcs1, manea, mgat2, mgat5b, b4galt3, and b4galt4) were differentially expressed over 1.5-fold of the control, and all these genes were down-regulated. ...
After 3 days of hyperosmotic culture, nine genes (ugp, slc35a3, slc35d2, gcs1, manea, mgat2, mgat5b, b4galt3, and b4galt4) were diffe …
Tissue-specific mRNA expression profiles of human solute carrier 35 transporters.
Nishimura M, Suzuki S, Satoh T, Naito S. Nishimura M, et al. Drug Metab Pharmacokinet. 2009;24(1):91-9. doi: 10.2133/dmpk.24.91. Drug Metab Pharmacokinet. 2009. PMID: 19252338 Free article.
The mRNA expression level of each target transporter was analyzed in total RNA from single and pooled specimens of adult human tissues (adipose tissue, adrenal gland, bladder, bone marrow, brain, cerebellum, colon, heart, kidney, liver, lung, mammary gland, ovary, pancreas, perip …
The mRNA expression level of each target transporter was analyzed in total RNA from single and pooled specimens of adult human tissues (adip …
MDA-MB-231 breast cancer cell viability, motility and matrix adhesion are regulated by a complex interplay of heparan sulfate, chondroitin-/dermatan sulfate and hyaluronan biosynthesis.
Viola M, Brüggemann K, Karousou E, Caon I, Caravà E, Vigetti D, Greve B, Stock C, De Luca G, Passi A, Götte M. Viola M, et al. Glycoconj J. 2017 Jun;34(3):411-420. doi: 10.1007/s10719-016-9735-6. Epub 2016 Oct 15. Glycoconj J. 2017. PMID: 27744520
Interestingly, EXT1-depleted cells showed a downregulation of the UDP-sugar transporter SLC35D1, whereas SLC35D2 was downregulated in beta4GalT7-depleted cells, indicating an intricate regulatory network that connects all glycosaminoglycans synthesis. ...
Interestingly, EXT1-depleted cells showed a downregulation of the UDP-sugar transporter SLC35D1, whereas SLC35D2 was downregulated in …
11 results